Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes.

abstract：:Four amino acids--alanine, 2,3-diaminopropionic acid, cystine, and cystein--and also one diamine, ethylenediamine, were chelated with 99m-technetium (99mTc), and their renal excretion patterns were studied in rabbits in the presence and absence of two renal tubular transport inhibitors, probenecid and 2,4-dinitropheno...

journal_title：Journal of inorganic biochemistry

authors： Chattopadhyay M,Banerjee S

更新日期：1988-09-01 00:00:00

abstract：:Cross-linked enzyme aggregate (CLEA) methodology has been applied to immobilize cytochrome P450 BM3 variants (F87A and 21B3) with peroxygenase activity. Several Ru(II)-diimine complexes were found to be suitable cross-linking agents, surpassing the traditional glutaraldehyde and dextran aldehyde. They offer modular nu...

journal_title：Journal of inorganic biochemistry

authors： Do MQ,Henry E,Kato M,Cheruzel L

更新日期：2018-09-01 00:00:00

abstract：:Chromium(VI) compounds (e.g. chromates) are cytotoxic, mutagenic, and potentially carcinogenic. The reduction of Cr(VI) can yield reactive intermediates such as Cr(V) and reactive oxygen species. Bronchial epithelial cells are the primary site of pulmonary exposure to inhaled Cr(VI) and are the primary cells from whic...

journal_title：Journal of inorganic biochemistry

authors： Borthiry GR,Antholine WE,Myers JM,Myers CR

更新日期：2008-07-01 00:00:00

abstract：:A series of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines has been prepared. The complexes have the following composition: cis-[Pt(Boh)(2)Cl(2)] (1), cis-[Pt(Oc)(2)Cl(2)] (2), cis-[Pt(Ros)(2)Cl(2)] (3), cis-[Pt(i-PrOc)(2)Cl(2)] (4), cis-[Pt(BohH(+))(2)Cl(2)]Cl(2) (5), cis-[Pt(OcH(+))(2)Cl(2)]Cl(2)...

journal_title：Journal of inorganic biochemistry

authors： Malon M,Trávnícek Z,Marek R,Strnad M

更新日期：2005-11-01 00:00:00

abstract：:Ternary systems of copper(II) complexes with phosphoserine and adenosine 5'-monophosphate or adenosine 5'-diphosphate or adenosine 5'-triphosphate have been investigated. The studies have been performed in aqueous solution using the potentiometric method with computer analysis of the data, (13)C and (31)P nuclear magn...

journal_title：Journal of inorganic biochemistry

authors： Jastrzab R

更新日期：2009-05-01 00:00:00

abstract：:Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray ...

journal_title：Journal of inorganic biochemistry

authors： Ahmad Khan R,Al-Farhan K,de Almeida A,Alsalme A,Casini A,Ghazzali M,Reedijk J

更新日期：2014-11-01 00:00:00

abstract：:The results are reported of a potentiometric and spectrophotometric study of the proton and copper(II) complexes of methionine enkephalin and four related pentapeptides which all show greater biological activity than their parent enkephalin. Measurements were carried out at 25 degrees C and I = 0.10 mol dm-3 (KNO3). A...

journal_title：Journal of inorganic biochemistry

authors： Formicka-Kozlowska G,Pettit LD,Steel I,Livera CE,Kupryszewski G,Rolka K

更新日期：1985-08-01 00:00:00

abstract：:Preparation of metal/protein hybrids is growing into important topics in the field of bioinorganic chemistry. X-ray crystal structure analyses of them provide direct information on unique interactions of metal cations or metal cofactors to understand and design enzymatic functions. In this mini review, the authors foc...

journal_title：Journal of inorganic biochemistry

authors： Ueno T,Yokoi N,Abe S,Watanabe Y

更新日期：2007-11-01 00:00:00

abstract：:Heart tissue becomes zinc-depleted and the capacity to mobilize labile zinc is diminished, indicating zinc dyshomeostasis during ischemia/reperfusion (I/R). Apparently, zinc pyrithione restores the basal zinc levels during I/R and prevents apoptosis by activating phosphatidyl inositol-3-kinase/Akt and targeting mitoch...

journal_title：Journal of inorganic biochemistry

authors： Bodiga VL,Thokala S,Vemuri PK,Bodiga S

更新日期：2015-12-01 00:00:00

abstract：:When pulsed cytochrome c oxidase is exposed to carbon monoxide in the absence of oxygen the enzyme is converted quickly to its CO-associated mixed valence state. The half-time for this reaction at 0 degree C is about 4 min. This is about 100 times faster than a similar reaction which begins with the resting form of th...

journal_title：Journal of inorganic biochemistry

authors： Morgan JE,Blair DF,Chan SI

更新日期：1985-03-01 00:00:00

abstract：:The proton equilibrium in aqueous surfactant solutions of hemin, (PPIX)Fe(H2O)+2, involving the propionic acid groups is reported (PPIX = protoporphyrinato IX). The surfactant used are sodium dodecyl sulphate (SDS), triton X-100 (TX-100) and hexadecyl trimethylammonium bromide (CTAB). The pKa values, determined spectr...

journal_title：Journal of inorganic biochemistry

authors： Das DK,Medhi OK

更新日期：1998-05-01 00:00:00

abstract：:The reaction of human ceruloplasmin and anion treated ceruloplasmin with diethyldithiocarbamate was studied at pH 5.5. The analysis of optical and EPR spectra at 9 GHz showed that ceruloplasmin contains five paramagnetic copper ions, two of which, X and Y, not involved in enzymatic activity, are chelated by diethyldit...

journal_title：Journal of inorganic biochemistry

authors： Herve M,Garnier-Suillerot A,Tosi L,Steinbuch M

更新日期：1985-10-01 00:00:00

abstract：:In a quest for more effective radiopharmaceuticals for pain palliation of metastatic bone cancer, this paper relates results obtained with 166Ho and 153Sm complexed to the bone seeking phosphonate, N,N-dimethylenephosphonate-1-hydroxy-4-aminopropylidenediphosphonate (APDDMP). APDDMP is synthesised from the known bone ...

journal_title：Journal of inorganic biochemistry

authors： Zeevaart JR,Jarvis NV,Louw WK,Jackson GE

更新日期：2001-01-01 00:00:00

abstract：:Biological studies on [Fe(L)2](NO3).0.5H2O (1), [Fe(L)2][PF6] (2), [Co(L)2](NCS) (3), [Ni(HL)2]Cl2.3H2O (4) and Cu(L)(NO3) (5), where HL=C7H8N4S, pyridine-2-carbaldehyde thiosemicarbazone, have been carried out. The crystal structure of compound 3 has been solved. It consists of discrete monomeric cationic entities co...

journal_title：Journal of inorganic biochemistry

authors： García-Tojal J,García-Orad A,Díaz AA,Serra JL,Urtiaga MK,Arriortua MI,Rojo T

更新日期：2001-04-01 00:00:00

abstract：:The effect of Cu(II), Ni(II), Zn(II), Mg(II), and Mn(II) on the fluorescence of porcine kidney cytosol leucine aminopeptidase and three of its dansyl(Dns) peptide substrates, Leu-Gly-NHNH-Dns, Leu-Gly-NH(CH2)2NH-Dns, and Leu-Gly-NH(CH2)6NH-Dns, has been investigated. These five metal ions were chosen for study because...

journal_title：Journal of inorganic biochemistry

authors： Lin WY,Van Wart HE

更新日期：1988-01-01 00:00:00

abstract：:A series of iminopyridine complexes of platinum(II), bearing a flexible diethereal, aryl terminated residue, where the size of aryl group is varied from phenyl to 9-anthracenyl, was synthesized. The new complexes are soluble and stable in DMSO/H2O mixtures. Besides the metal center, aryl groups are available for furth...

journal_title：Journal of inorganic biochemistry

authors： Bondi R,Dalla Via L,Hyeraci M,Pagot G,Labella L,Marchetti F,Samaritani S

更新日期：2020-12-15 00:00:00

abstract：:The relationship between respiratory and neurological effects of exposure to aluminium (Al) was investigated in a group of foundry workers exposed to Al at concentrations below the threshold limit value (TLV) binding in Poland (2.0 mg Al2O3 m(-3)). Neurological and neurophysiological parameters indicated subclinical e...

journal_title：Journal of inorganic biochemistry

authors： Halatek T,Sinczuk-Walczak H,Rydzynski K

更新日期：2005-09-01 00:00:00

abstract：:Iron deficiency anemia is a relatively common illness that can arise from a number of different causes. Three ferrous salts are usually used in its treatment: ferrous fumarate, gluconate, and sulfate. They are administered orally and are relatively well tolerated. These hematinics have been studied by Mössbauer spectr...

journal_title：Journal of inorganic biochemistry

authors： Coe EM,Bowen LH,Bereman RD

更新日期：1995-06-01 00:00:00

abstract：:The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O and [Ni(sulfapyridine)(2)] were studied and compared with similar previously reported copper complexes. [Ni(sulfisoxazole)(2)(H(2)O)(4)].2H(2)O crystallized in a monoclinic system,...

journal_title：Journal of inorganic biochemistry

authors： Mondelli M,Bruné V,Borthagaray G,Ellena J,Nascimento OR,Leite CQ,Batista AA,Torre MH

更新日期：2008-02-01 00:00:00

abstract：:The clinical efficiency of Pt(II)-based drugs is founded on articulate mechanisms of action. Indeed it depends on a balanced combination of metal ion reactivity towards proteins and nucleic acids. Here we analysed the effect of two trans-platinum planar amines in comparison to cisplatin and transplatin on the DNA proc...

journal_title：Journal of inorganic biochemistry

authors： Pinato O,Benettazzo A,Dalla Via L,Farrell NP,Sissi C

更新日期：2020-10-01 00:00:00

abstract：:The entire nirK gene coding for a putative copper-nitrite reductase (Nir) from Sinorhizobium meliloti 2011 (Sm) was cloned and overexpressed heterologously in Escherichia coli for the first time. The spectroscopic and molecular properties of the enzyme indicate that SmNir is a green Nir with homotrimeric structure (42...

journal_title：Journal of inorganic biochemistry

authors： Ferroni FM,Guerrero SA,Rizzi AC,Brondino CD

更新日期：2012-09-01 00:00:00

abstract：:Insulin resistance is identified through numerous pathophysiological conditions, such as Diabetes mellitus II, obesity, hypertension and other metabolic syndromes. Enhancement of insulin action and\or its complete replacement by insulin-enhancing or insulin-mimetic agents seems to improve treatment of metabolic diseas...

journal_title：Journal of inorganic biochemistry

authors： Tsave O,Yavropoulou MP,Kafantari M,Gabriel C,Yovos JG,Salifoglou A

更新日期：2016-10-01 00:00:00

abstract：:Transition metal homeostasis is necessary to sustain life. First row transition metals act as cofactors within the cell, performing vital functions ranging from DNA repair to respiration. However, intracellular metal concentrations exceeding physiological requirements may be toxic. In E. coli, the YqjH flavoprotein is...

journal_title：Journal of inorganic biochemistry

authors： Blahut M,Dzul S,Wang S,Kandegedara A,Grossoehme NE,Stemmler T,Outten FW

更新日期：2018-07-01 00:00:00

abstract：:Al(III) toxicity in living organisms is based on competition with other metal cations. Mg(II) is one of the most affected cations, since the size similarity dominates over the charge identity. The slow ligand exchange rates for Al(III) render the ion useless as a metal ion at the active sites of enzymes and provide a ...

journal_title：Journal of inorganic biochemistry

authors： Rezabal E,Mercero JM,Lopez X,Ugalde JM

更新日期：2006-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an alternative treatment widely used against cancer. PDT requires molecular systems, known as photosensitizers (PS), which not only exhibit strong absorption at a particular wavelength range, but also need to be selectively accumulated inside cancer cells. PS are activated by specific wav...

journal_title：Journal of inorganic biochemistry

authors： Noriega L,Castro ME,Perez-Aguilar JM,Caballero NA,Sanchez-Gaytan BL,González-Vergara E,Melendez FJ

更新日期：2020-02-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) generates superoxide, particularly at sub-optimal l-arginine (l-Arg) substrate concentrations. Heat shock protein 90 (Hsp90) was reported to inhibit superoxide generation from nNOS protein. However, commercially available Hsp90 product from bovine brain tissues with unspecified Hs...

journal_title：Journal of inorganic biochemistry

authors： Zheng H,Weaver JM,Feng C

更新日期：2021-01-01 00:00:00

abstract：:The stability constants of the mixed ligand complexes formed between Cu(Arm)2+, where Arm=2,2'-bipyridine (Bpy) or 1,10-phenanthroline (Phen), and the monoanion or the dianion of 9-(4-phosphonobutyl)adenine (dPMEA=3'-deoxa-PMEA), which is the carba analogue of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenin...

journal_title：Journal of inorganic biochemistry

authors： Gómez-Coca RB,Kapinos LE,Holý A,Vilaplana RA,González-Vílchez F,Sigel H

更新日期：2001-03-01 00:00:00

abstract：:Complex formation between D-penicillamine (Pen) and copper(II) ions has been studied under simulated physiological conditions in both the presence and absence of the blood plasma constituents albumin, alanine, histidine, and zinc(II). Chromatographic and uv/vis and electron spin resonance (esr) spectroscopic methods w...

journal_title：Journal of inorganic biochemistry

authors： Laurie SH,Prime DM

更新日期：1979-11-01 00:00:00

abstract：:Zincon (ZI) is one of the most common chromophoric chelating probes for the determination of Zn2+ and Cu2+ ions. It is also known to bind other metal ions. However, literature data on its binding properties and molar absorption coefficients are rather poor, varying among publications or determined only in certain cond...

journal_title：Journal of inorganic biochemistry

authors： Kocyła A,Pomorski A,Krężel A

更新日期：2017-11-01 00:00:00

abstract：:Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of...

journal_title：Journal of inorganic biochemistry

authors： Crisponi G,Nurchi VM,Pivetta T,Gałezowska J,Gumienna-Kontecka E,Bailly T,Burgada R,Kozłowski H

更新日期：2008-07-01 00:00:00