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Synthesis, anticancer activities, interaction with DNA and mitochondria of manganese complexes.

Abstract：

:Two new complexes [(Etdpa)MnCl(2)] and [(Adpa)Mn(Cl)(H(2)O)] (Etdpa = ethyl bis(2-pyridylmethyl)amino-2-propionate; Adpa = bis(2-pyridylmethyl)amino-2-propionic acid) were synthesized and characterized by spectral methods. The crystal structure of [(Etdpa)MnCl(2)] shows that the Mn(II) atom is coordinated by three N atoms (N1, N2, N3), one oxygen atom (O1) of the ligand (Etdpa) and two chloride atoms (Cl1, Cl2), forming a distorted octahedral geometry. The binding interaction between ct-DNA and the synthesized complexes was relatively weak, but they can inhibit the induced swelling of Ca(2+)-loaded mitochondria in a dose-dependent manner. The [(Adpa)Mn(Cl)(H(2)O)] can cause the obvious decrease of mitochondria membrane potential. The MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenpyltetra-zolium bromide) assay shows that the two Mn(II) complexes are more active against cancer cells. Especially [(Adpa)Mn(Cl)(H(2)O)] can inhibit the proliferation of glioma cells with IC(50) 9.5 μM. Experimental results indicate that the [(Adpa)Mn(Cl)(H(2)O)] could be a new potential antitumor complex to target the mitochondria.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Qiu-Yun C,Dong-Fang Z,Juan H,Wen-Jie G,Jing G

doi

10.1016/j.jinorgbio.2010.06.012

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1141-7

issue

11

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(10)00155-8

journal_volume

104

pub_type

杂志文章

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