A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled species.


:The gallium(III) complex of a new tripodal 3-hydroxy-4-pyridinone (3,4-HP) chelator has been studied in terms of its physico-chemical and in vivo properties aimed at potential application as probe for nuclear imaging. In particular, based on spectrophotometric titrations, the hexa-coordinated (1:1) gallium complex appeared as the major species in a wide physiological acid-neutral pH range and its high stability (pGa=27.5) should avoid drug-induced toxicity resulting from Ga(III) accumulation in tissues due to processes of transmetallation with endogenenous ligands or demetallation. A multinuclear ((1)H and (71)Ga) NMR study gave some insights into the structure and dynamics of the gallium(III) chelate in solution, which are consistent with the tris-(3,4-HP) coordination and an eventual pseudo-octahedral geometry. Biodistribution and scintigraphic studies of the (67)Ga(III) labelled chelate, performed in Wistar rats, confirmed the in vivo stability of the radiolabelled complex, its non interaction with blood proteins and its quick renal clearance. These results indicate good perspectives for potential application of extrafunctionalized analogues in radiodiagnostic techniques.


J Inorg Biochem


Chaves S,Mendonça AC,Marques SM,Prata MI,Santos AC,Martins AF,Geraldes CF,Santos MA




Has Abstract


2011-01-01 00:00:00














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    authors: Barker BD,Larsen RW

    更新日期:2001-06-01 00:00:00

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    abstract::Samples of nano-MgO with varying particle sizes were prepared by four different methods using Mg(NO3)2.6H2O, Na2CO3, urea and ammonia as raw materials and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), low temperature N2 adsorption-desorption measurements and FT-IR spectroscopy. Bact...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Huang L,Li DQ,Lin YJ,Wei M,Evans DG,Duan X

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  • Spectroscopic characterization of genotoxic chromium(V) peptide complexes: Oxidation of Chromium(III) triglycine, tetraglycine and pentaglycine complexes.

    abstract::Evidence is growing that metabolites of Cr(III) dietary supplements are partially oxidized to carcinogenic Cr(VI) and Cr(V) in vivo. Hence, we examined oxidations of Cr(III) peptide (triglycine, tetraglycine and pentaglycine) complexes to Cr(VI) and Cr(V) by PbO2 at 37°C and physiological pH values between 3.85 and 7....

    journal_title:Journal of inorganic biochemistry

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    authors: Headlam HA,Lay PA

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    abstract::Commercially available chromium supplements were tested for their DNA cleavage ability compared with synthetic chromium(III) complexes, including chromium(III) tris-picolinate [Cr(pic)3], basic chromium acetate [Cr3O(OAc)6]+, model complexes, and recently patented Cr-complexes for use in supplements or therapy. Four d...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Chaudhary S,Pinkston J,Rabile MM,Van Horn JD

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    journal_title:Journal of inorganic biochemistry

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    authors: Battin EE,Brumaghim JL

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    abstract::Shape analysis of coordination complexes is well-suited to evaluate the subtle distortions in the trigonal bipyramidal (TBPY-5) geometry of vanadium coordinated in the active site of phosphatases and characterized by X-ray crystallography. Recent studies using the tau (τ) analysis support the assertion that vanadium i...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Sánchez-Lombardo I,Alvarez S,McLauchlan CC,Crans DC

    更新日期:2015-06-01 00:00:00

  • Copper(II) and zinc(II) complexes of the peptides Ac-HisValHis-NH2 and Ac-HisValGlyAsp-NH2 related to the active site of the enzyme CuZnSOD.

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Bóka B,Myari A,Sóvágó I,Hadjiliadis N

    更新日期:2004-01-01 00:00:00

  • New dimanganese(III) complexes of pentadentate (N2O3) Schiff base ligands with the [Mn2(mu-OAc)(mu-OR)2]3+ core: synthesis, characterization and mechanistic studies of H2O2 disproportionation.

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Biava H,Palopoli C,Shova S,De Gaudio M,Daier V,González-Sierra M,Tuchagues JP,Signorella S

    更新日期:2006-10-01 00:00:00

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: González-Alvarez M,Alzuet G,Borrás J,Macías B,del Olmo M,Liu-González M,Sanz F

    更新日期:2002-04-10 00:00:00

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Suwalsky M,Norris B,Cárdenas H

    更新日期:2005-12-01 00:00:00

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    authors: Kaps L,Biersack B,Müller-Bunz H,Mahal K,Münzner J,Tacke M,Mueller T,Schobert R

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Abraham LO,Li Y,Zamble DB

    更新日期:2006-05-01 00:00:00

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    journal_title:Journal of inorganic biochemistry

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    authors: Cook DB,Dewar JH,Ershadi SS

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    authors: Zheng T,Wan X,Zhang Q,Jin B,Peng RF

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    pub_type: 杂志文章


    authors: Adak S,Stuehr DJ

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Lukiw WJ,Percy ME,Kruck TP

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Biver T,Secco F,Tinè MR,Venturini M

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    journal_title:Journal of inorganic biochemistry

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    authors: Kocyła A,Pomorski A,Krężel A

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    pub_type: 杂志文章,评审


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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Adams C,Adams PA

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Chai K,Kuang W,Lan Z,Zhang L,Jiang Y,Han T,Niu J,Wang J,Duan X

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Messori L,Piccioli M

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    abstract::The reactivities of copper(II) complexes with histidine-containing oligopeptides towards active oxygen species such as hydrogen peroxide (H2O2) and superoxide ion (O2-) were investigated by electron spin resonance (ESR)-spin trapping and thiobarbituric acid (TBA) methods. At physiological pH values, Cu(II) complexes w...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Ueda J,Ozawa T,Miyazaki M,Fujiwara Y

    更新日期:1994-08-01 00:00:00

  • Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites.

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Fernández M,Arce ER,Sarniguet C,Morais TS,Tomaz AI,Azar CO,Figueroa R,Diego Maya J,Medeiros A,Comini M,Helena Garcia M,Otero L,Gambino D

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Nomiya K,Sekino K,Ishikawa M,Honda A,Yokoyama M,Chikaraishi Kasuga N,Yokoyama H,Nakano S,Onodera K

    更新日期:2004-04-01 00:00:00

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Tan YJ,Tan YS,Yeo CI,Chew J,Tiekink ERT

    更新日期:2019-03-01 00:00:00

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章,评审


    authors: Kustin K

    更新日期:2015-06-01 00:00:00

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Raner GM,Hatchell AJ,Morton PE,Ballou DP,Coon MJ

    更新日期:2000-08-31 00:00:00

  • Hexacyanochromate ion as a paramagnetic anion probe for active sites of enzymes.

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    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Inagaki F,Shimada I

    更新日期:1986-10-01 00:00:00

  • Effective cleavage of phosphodiester promoted by the zinc(II) and copper(II) inclusion complexes of β-cyclodextrin.

    abstract::To construct the model of metallohydrolase, two inclusion complexes [MLCl2(β-CD)] (1, M=Zn(II); 2, M=Cu(II); L=N,N'-bis(2-pyridylmethyl)amantadine; β-CD=β-cyclodextrin) were synthesized by mixing β-CDs with the pre-synthesized complexes G1, [ZnLCl2] and G2, [CuLCl2]. Structures of G1, G2, 1 and 2 were characterized by...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章


    authors: Zhou YH,Chen LQ,Tao J,Shen JL,Gong DY,Yun RR,Cheng Y

    更新日期:2016-10-01 00:00:00