Metal complexes of luteinizing hormone-releasing hormone (LHRH). potentiometric and spectroscopic studies.

Abstract:

:The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25 degrees C and an ionic strength 0.10 mol dm-3 (KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu2+ the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable [CuH-1L] complex involving coordination of three nitrogen donors: the Nim atom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni2+, coordination proceeds differently to give four nitrogen coordination.

journal_name

J Inorg Biochem

authors

Gerega K,Kozlowski H,Masiukiewicz E,Pettit LD,Pyburn S,Rzeszotarska B

doi

10.1016/0162-0134(88)80030-8

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

11-8

issue

1

eissn

0162-0134

issn

1873-3344

pii

0162-0134(88)80030-8

journal_volume

33

pub_type

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