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A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor.

Abstract：

:Two ruthenium(II) complexes (Ru-complexes) were synthesized and characterized in this study. The selectivity and ability of the complexes to interact with bcl-2 DNA were investigated here. It turned out that [Ru(ip)3](ClO4)2·2H2O (complex 1, ip = 1H-iminazole [4,5-f][1,10] phenanthroline) could induce and stabilize the formations of G-quadruplexes more effectively than [Ru(pip)3](ClO4)2·2H2O (complex 2, pip = 2-phenylimidazo-[4,5-f][1,10]phenanthroline) did. Considering the important role of the Ru-complex ligand in inducing and stabilizing the formations of G-quadruplex in our previous studies, we speculate that the overlarge ligand of complex 2 may block its binding affinity for G-quadruplexes. Complex 1 also induced cell apoptosis in in vitro assays. In general, this study provided potentially important information for further development of the Ru-complexes as good inducers and stabilizers of bcl-2 G-quadruplex DNA for cancer treatment.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Zhang J,Yu Q,Li Q,Yang L,Chen L,Zhou Y,Liu J

doi

10.1016/j.jinorgbio.2013.12.005

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

1-11

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(13)00332-2

journal_volume

134

pub_type

杂志文章

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