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Cu(II)-selective bispidine-dye conjugates.

Abstract：

:The substitution of tetradentate bispidine ligands with rhodamine and cyanine dye molecules, coupled to an amine donor, forming an amide as potential fifth donor, is described. Bispidines are known to lead to very stable Cu(II) complexes, and the coordination to Cu(II) was expected to efficiently quench the fluorescence of dye molecules. However, at physiological pH the amide is not coordinated, as shown by titration experiments and crystallographic structural data of three possible isomers of these complexes. This may be due to the specific cavity shape of bispidines and the Jahn-Teller lability of the Cu(II) center. While Cu(II) coordination in aqueous solution leads to efficient fluorescence quenching, experiments show that the complex stabilities are not large enough for Cu(II) sensing in biological media, and possibilities are discussed, how this may be achieved by optimized bispidine-dye conjugates.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Brox D,Comba P,Herten DP,Kimmle E,Morgen M,Rühl CL,Rybina A,Stephan H,Storch G,Wadepohl H

doi

10.1016/j.jinorgbio.2015.05.009

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

78-83

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(15)00138-5

journal_volume

148

pub_type

杂志文章

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