当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > A family of insulinomimetic zinc(II) complexes of amino ligands with Zn(Nn) (n=3 and 4) coordination modes.

A family of insulinomimetic zinc(II) complexes of amino ligands with Zn(Nn) (n=3 and 4) coordination modes.

Abstract：

:Several metal ions and their complexes have been known to mimic the action of insulin in in vitro and in vivo systems. We prepared a family of Zn(II) complexes derived from amino ligands with Zn(Nn) (n=3 and 4) coordination modes, the insulinomimetic activity being estimated by an inhibitory effect of free fatty acid release from isolated rat adipocytes treated with epinephrine. In comparison with the positive controls VOSO(4) and ZnSO(4), Zn(II)-amine complexes with stability constants (log beta) lower than 11.5 exhibited higher insulinomimetic activities. Among them, a bis(2-aminomethyl pyridinato)Zn(II) (Zn(2-ampy)(2)(2+)) complex with the highest insulinomimetic activity and a higher stability constant but lower than 11.5 was selected, and subjected to in vivo evaluation in KK-A(y) mice with a genetically type 2 diabetes mellitus. The high blood glucose level of the mice was lowered by daily intraperitoneal injections of Zn(2-ampy)(2)(2+) at a dose of 2 mg Zn/kg body weight for 14 days. Based on the results, Zn(2-ampy)(2)(2+) with Zn(N(4)) coordination mode was proposed to have both a high in vitro insulinomimetic activity and an in vivo blood glucose lowering effect.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Yoshikawa Y,Kondo M,Sakurai H,Kojima Y

doi

10.1016/j.jinorgbio.2005.04.011

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

1497-503

issue

7

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(05)00106-6

journal_volume

99

pub_type

杂志文章

相关文献

JOURNAL OF INORGANIC BIOCHEMISTRY文献大全
  • Copper transfer from Rhus vernicifera laccase.

    abstract：:Tree laccase, a multi-copper oxidase, has been studied as a copper donor in conjunction with the demetalated forms of three blue copper proteins. Copper transfer could be observed under reducing conditions in the absence of air. Only about 10% of the total copper in laccase could be transferred regardless of the amoun...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(91)80017-c

    authors： Meadows KA,Morie-Bebel MM,McMillin DR

    更新日期：1991-03-01 00:00:00

  • Dietary selenium influences pancreatic tissue levels of selenoprotein W in chickens.

    abstract：:Selenium (Se) influences the levels of selenoprotein W (SelW) in mammals. However, little is known about the pattern of SelW expression in the pancreatic tissue of birds. To investigate the effects of dietary Se levels on the expression of SelW mRNA in the pancreatic tissue of birds, one-day-old chickens were randomly...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2011.05.022

    authors： Wang R,Sun B,Zhang Z,Li S,Xu S

    更新日期：2011-09-01 00:00:00

  • Unusual reactivity in a commercial chromium supplement compared to baseline DNA cleavage with synthetic chromium complexes.

    abstract：:Commercially available chromium supplements were tested for their DNA cleavage ability compared with synthetic chromium(III) complexes, including chromium(III) tris-picolinate [Cr(pic)3], basic chromium acetate [Cr3O(OAc)6]+, model complexes, and recently patented Cr-complexes for use in supplements or therapy. Four d...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2004.12.009

    authors： Chaudhary S,Pinkston J,Rabile MM,Van Horn JD

    更新日期：2005-03-01 00:00:00

  • Protein interactions with bivalent tin. 1. Hydrolysis and complexation of tin(II) ion with glycine.

    abstract：:The complexation between tin(II) ion and glycine was studied in 0.15 mol/dm3 NaCl medium at 310 K using potentiometric glass electrode titrations. In the pH range 1.1-4.5 and concentration range of the tin(II) between 0.2 and 5.0 mmol/dm3, with variable glycine-to-tin molar ratio up to 10:1, the experimental data were...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(95)00085-2

    authors： Djurdjevic P,Djokic D

    更新日期：1996-04-01 00:00:00

  • Pseudomonas aeruginosa cytochrome C(551): probing the role of the hydrophobic patch in electron transfer.

    abstract：:Cytochrome c(551) from Pseudomonas aeruginosa is a monomeric redox protein of 82 amino-acid residues, involved in dissimilative denitrification as the physiological electron donor of cd(1) nitrite reductase. The distribution of charged residues on the surface of c(551) is very anisotropic: one side is richer in acidic...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(01)00390-7

    authors： Cutruzzolà F,Arese M,Ranghino G,van Pouderoyen G,Canters G,Brunori M

    更新日期：2002-02-01 00:00:00

  • Non-covalent interactions in blue copper protein probed by Met16 mutation and electronic and resonance Raman spectroscopy of Achromobacter cycloclastes pseudoazurin.

    abstract：:We have used low-temperature (77K) resonance Raman (RR) spectroscopy as a probe of the electronic and molecular structure to investigate weak pi-pi interactions between the metal ion-coordinated His imidazoles and aromatic side chains in the second coordination sphere of blue copper proteins. For this purpose, the RR ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2009.11.004

    authors： Fitzpatrick MB,Obara Y,Fujita K,Brown DE,Dooley DM,Kohzuma T,Czernuszewicz RS

    更新日期：2010-03-01 00:00:00

  • Cell death by reactive oxygen species generated from water-soluble cationic metalloporphyrins as superoxide dismutase mimics.

    abstract：:We investigated the effect on cell death of reactive oxygen species induced by water-soluble cationic metalloporphyrins with superoxide dismutase (SOD) activity. The SOD activity of 5,10,15,20-tetrakis(4-N-methylpyridyl)]porphine (MPy(4)P) containing Fe, Mn or Cu was measured using a cytochrome c assay by the xanthine...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(01)00187-8

    authors： Ohse T,Nagaoka S,Arakawa Y,Kawakami H,Nakamura K

    更新日期：2001-06-01 00:00:00

  • Unfolding cytochromes c-b562 and Rd apo b562.

    abstract：:We have analyzed the early stages of unfolding of cytochromes c-b562 (PDB ID: 2BC5) and Rd apo b562 (PDB ID: 1YYJ). Our geometrical approach proceeds from an analysis of the crystal structure reported for each protein. We quantify, residue-by-residue and region-by-region, the spatial and angular changes in the structu...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111209

    authors： Kozak JJ,Gray HB,Garza-López RA

    更新日期：2020-10-01 00:00:00

  • Reactions of triethylphosphine gold(I) complexes with heme proteins: novel spin-state changes in cytochrome b562, myoglobin, and hemoglobin.

    abstract：:Reactions of bacterial Fe(III) cyt b562, HbO2, met Hb and met Mb with Et3PAuCl and Et3PAuNO3 (and some related complexes) have been investigated by electronic absorption and EPR and NMR spectroscopy. Except for met Hb, which denatured, the products were novel high-spin Fe(III) heme proteins. The reactions of cyt b562 ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(86)80104-0

    authors： Grootveld MC,Otiko G,Sadler PJ,Cammack R

    更新日期：1986-05-01 00:00:00

  • Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat.

    abstract：:Fe(III)-salen (N,N-bis(salicylidene)-ethane-1,2-diimine) complexes of simple hydroxamic acids and the MMP (matrix metalloproteinase) inhibitor marimastat have been evaluated as hypoxia activated drug carriers. The aceto- (aha), propion- (pha), benzohydroxamato (bha), and marimastat complexes were prepared and characte...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2006.11.003

    authors： Failes TW,Hambley TW

    更新日期：2007-03-01 00:00:00

  • Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II.

    abstract：:The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.04.016

    authors： Accardo A,Laurent SA,Mazarguil H,Meyer M,Robert A,Meunier B

    更新日期：2007-11-01 00:00:00

  • 3D-QSAR study for DNA cleavage proteins with a potential anti-tumor ATCUN-like motif.

    abstract：:Genomics projects have elucidated several genes that encode protein sequences. Subsequently, the advent of the proteomics age has enabled the synthesis and 3D structure determination for these protein sequences. Some of these proteins incorporate metal atoms but it is often not known whether they are metal-binding pro...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2006.02.019

    authors： González-Díaz H,Sánchez-González A,González-Díaz Y

    更新日期：2006-07-01 00:00:00

  • Stabilization of the T-state of ferrous human adult and fetal hemoglobin by Ln(III) complexes: a thermodynamic study.

    abstract：:The effect of the lanthanide(III) complexes [Gd(1,4,7,10-tetraazacyclododecane-N,N',N", N"'-tetrakis(methylenephosphonate))]5- (Gd-DOTP) and La-DOTP on the oxygen binding and spectroscopic properties of human adult and fetal hemoglobin (HbA and HbF, respectively) has been investigated. The affinity of Gd-DOTP and La-D...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(98)10030-2

    authors： Aime S,Fasano M,Paoletti S,Bellelli A,Coletta M,Ascenzi P

    更新日期：1998-08-01 00:00:00

  • Vanadium and insulin: Partners in metabolic regulation.

    abstract：:Since the 1970s, the biological role of vanadium compounds has been discussed as insulin-mimetic or insulin-enhancer agents. The action of vanadium compounds has been investigated to determine how they influence the insulin signaling pathway. Khan and coworkers proposed key proteins for the insulin pathway study, intr...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111094

    authors： Treviño S,Diaz A

    更新日期：2020-07-01 00:00:00

  • Coordination modes of histidine. 4. Coordination structures in the copper(II)-L-histidine (1:2) system.

    abstract：:The coordination structures of various species in the copper(II)-L-histidine (1:2) system in aqueous solution have been deduced by investigating the pH dependence of the electronic and circular dichroism spectra. The contribution to the spectra of the glycine-like and histamine-like binding modes of L-histidine has be...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(83)85036-3

    authors： Casella L,Gullotti M

    更新日期：1983-02-01 00:00:00

  • Behavior of the potential antitumor V(IV)O complexes formed by flavonoid ligands. 1. Coordination modes and geometry in solution and at the physiological pH.

    abstract：:The coordination modes and geometry assumed in solution by the potent antitumor oxidovanadium(IV) complexes formed by different flavonoids were studied by spectroscopic (Electron Paramagnetic Resonance, EPR) and computational (Density Functional Theory, DFT) methods. A series of bidentate flavonoid ligands (L) with in...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2014.07.007

    authors： Sanna D,Ugone V,Lubinu G,Micera G,Garribba E

    更新日期：2014-11-01 00:00:00

  • The formation and nature of the mixed valence copper-D-penicillamine-chloride cluster in aqueous solution and its relevance to the treatment of Wilson's disease.

    abstract：:Complex formation between D-penicillamine (Pen) and copper(II) ions has been studied under simulated physiological conditions in both the presence and absence of the blood plasma constituents albumin, alanine, histidine, and zinc(II). Chromatographic and uv/vis and electron spin resonance (esr) spectroscopic methods w...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(00)80020-3

    authors： Laurie SH,Prime DM

    更新日期：1979-11-01 00:00:00

  • Vanadyl-biguanide complexes as potential synergistic insulin mimics.

    abstract：:Vanadium has well-documented blood-glucose-lowering properties both in vitro and in vivo. The design of new oxovanadium(IV) coordination compounds, intended for use as insulin-enhancing agents in the treatment of diabetes mellitus, can potentially benefit from a synergistic approach, in which the whole complex has mor...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(99)00152-x

    authors： Woo LC,Yuen VG,Thompson KH,McNeill JH,Orvig C

    更新日期：1999-09-30 00:00:00

  • Heteroditopic P,N ligands in gold(I) complexes: synthesis, structure and cytotoxicity.

    abstract：:New heteroditopic, bi- and multidentate imino- and aminophosphine ligands were synthesised and complexed to [AuCl(THT)] (THT=tetrahydrothiophene). X-ray crystallography confirmed Schiff base formation in three products, the successful reduction of the imino-group to the sp(3)-hybridised amine in several instances, and...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2015.01.014

    authors： Traut-Johnstone T,Kanyanda S,Kriel FH,Viljoen T,Kotze PD,van Zyl WE,Coates J,Rees DJ,Meyer M,Hewer R,Williams DB

    更新日期：2015-04-01 00:00:00

  • Metal-thiolate clusters in neuronal growth inhibitory factor (GIF).

    abstract：:Human neuronal growth inhibitory factor (GIF) is a metallothionein-like protein specific to the central nervous system, which has been linked to Alzheimer's disease. In this article a short overview of the biological and structural properties of native Cu4,Zn3-GIF are described. Moreover, metal-thiolate clusters forme...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/s0162-0134(99)00164-6

    authors： Vasák M,Hasler DW,Faller P

    更新日期：2000-04-01 00:00:00

  • Coordination chemistry and solution structure of Fe(II)-peplomycin. Two possible coordination geometries.

    abstract：:The solution structure of Fe(II)-peplomycin was determined from NMR data collected for this molecule. As found previously for Fe(II)- and Co(II)-bound bleomycin; the coordination sphere of the metal is composed of the primary and secondary amines in β-aminoalanine, the pyrimidine and imidazole rings in the pyrimidinyl...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.02.020

    authors： Li Y,Lehmann T

    更新日期：2012-06-01 00:00:00

  • Relationship between the antiproliferative properties of Cu(II) complexes with the Schiff base derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil and the redox status mediated by antioxidant defense systems on glioma tumoral cells.

    abstract：:A set of new copper(II) complexes containing the Schiff base ligand derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil (6-amino-1,3-dimethyl-5-[(pyridin-2-ylmethylidene)-amino]-pyrimidine-2,4(1H,3H)-dione) with several anions (Cl-, Br-, I-, ClO4-, NO3-) and, two of them with 1,10-phenanthroline,...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111053

    authors： Illán-Cabeza NA,Jiménez-Pulido SB,Hueso-Ureña F,Ramírez-Expósito MJ,Martínez-Martos JM,Moreno-Carretero MN

    更新日期：2020-06-01 00:00:00

  • The binding of [(en)Pt(mu-dpzm)2Pt(en)]4+ to G/C-rich regions of DNA.

    abstract：:The non-covalent binding of [(en)Pt(mu-dpzm)2Pt(en)]4+ to segments of DNA containing only G and C bases has been studied to gain an understanding of the pre-covalent binding association of cationic polynuclear platinum(II) anti-cancer drugs at G/C sites. 1H-NMR and CD spectroscopy were used to study the binding of the...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(00)00206-3

    authors： Wheate NJ,Cutts SM,Phillips DR,Aldrich-Wright JR,Collins JG

    更新日期：2001-03-01 00:00:00

  • Effect of cadmium on ferredoxin:NADP+ oxidoreductase activity.

    abstract：:Ferredoxin:NADP(+) oxidoreductase (FNR) was treated with cadmium and after that its diaphorase reaction in the presence of dibromothymoquinone (DBMIB) or ferricyanide (FeCy, K(3)Fe(CN)(6)) was examined. CdSO(4) (5 mM) caused 50% inhibition after half hour incubation. At least two components were distinguishable in the...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2004.04.004

    authors： Grzyb J,Waloszek A,Latowski D,Wieckowski S

    更新日期：2004-08-01 00:00:00

  • Correlating the structures and activities of the resting oxidized and native intermediate states of a small laccase by paramagnetic NMR.

    abstract：:Multicopper oxidases (MCO) are the fastest and most efficient known catalysts of the oxygen-reduction reaction. When all four copper ions are oxidized during catalysis, the native intermediate state (NI) decays in seconds to the resting oxidized state (RO), which returns to the catalytic cycle via reduction, but at a ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.02.002

    authors： Machczynski MC,Babicz JT Jr

    更新日期：2016-06-01 00:00:00

  • A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor.

    abstract：:Two ruthenium(II) complexes (Ru-complexes) were synthesized and characterized in this study. The selectivity and ability of the complexes to interact with bcl-2 DNA were investigated here. It turned out that [Ru(ip)3](ClO4)2·2H2O (complex 1, ip = 1H-iminazole [4,5-f][1,10] phenanthroline) could induce and stabilize th...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2013.12.005

    authors： Zhang J,Yu Q,Li Q,Yang L,Chen L,Zhou Y,Liu J

    更新日期：2014-05-01 00:00:00

  • Novel short-chain analogues of somatostatin as ligands for Cu(II) ions. Role of the metal ion binding on the spatial structure of the ligand.

    abstract：:In this paper we present the studies on coordination abilities of two short-chain analogues of somatostatin with free N-terminal and protected amino group towards copper (II) ions. The octreotide is the most popular analogue of the somatostatin (peptide hormone) used in medicine. Somatostatin analogues are used in dia...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.08.023

    authors： Marciniak A,Cebrat M,Czyżnikowska Ż,Brasuń J

    更新日期：2012-12-01 00:00:00

  • Synthesis, crystal structure and interaction with DNA and HSA of (N,N'-dibenzylethane-1,2-diamine) transition metal complexes.

    abstract：:A new ligand, N,N'-dibenzylethane-1,2-diamine (L) and its four transition metal(II) complexes, ML(2)(OAc)(2).2H(2)O (M=Cu, Ni, Zn, Co), have been synthesized and characterized by elemental analysis, mass spectra, molar conductivity, NMR and IR. Moreover, the crystals structure of Cu(II) and Ni(II) complexes characteri...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2008.08.005

    authors： Wu SS,Yuan WB,Wang HY,Zhang Q,Liu M,Yu KB

    更新日期：2008-11-01 00:00:00

  • The copper(II) binding properties of the cyclic peptide c(HGHK).

    abstract：:The new cyclic tetrapeptide c(HGHK) was synthesised in the solid phase and its complexes with copper(II) were studied in aqueous solution at various pH values by means of potentiometric and spectroscopic methods (UV, EPR, CD). Six mononuclear coordination species were clearly identified within the pH range 3-11. Spect...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2004.09.007

    authors： Brasun J,Gabbiani C,Ginanneschi M,Messori L,Orfei M,Swiatek-Kozlowska J

    更新日期：2004-12-01 00:00:00

  • Non-innocent bma ligand in a dissymetrically disubstituted diiron dithiolate related to the active site of the [FeFe] hydrogenases.

    abstract：:The purpose of the present study was to evaluate the use of a non-innocent ligand as a surrogate of the anchored [4Fe4S] cubane in a synthetic mimic of the [FeFe] hydrogenase active site. Reaction of 2,3-bis(diphenylphosphino) maleic anhydride (bma) with [Fe(2)(CO)(6)(mu-pdt)] (propanedithiolate, pdt=S(CH(2))(3)S) in ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2010.05.011

    authors： Si Y,Charreteur K,Capon JF,Gloaguen F,Pétillon FY,Schollhammer P,Talarmin J

    更新日期：2010-10-01 00:00:00