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Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II.

Abstract：

:The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a mimic of PfHRP-II putative heme binding sequence, are of the same order of magnitude, namely 42 and 14 s(-1), respectively. Despite the intrinsic reactivity of the carbonyl at C10 of heme-art toward a hydroxyl function, a peptide containing a serine or threonine residue does not readily react with heme-art adducts. Therefore, a much higher affinity of heme-art compared to heme toward PfHRP-II, if so, must be induced by a specific interaction or a chemical reaction, these phenomena being both due to the tertiary structure of the parasite protein itself.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Accardo A,Laurent SA,Mazarguil H,Meyer M,Robert A,Meunier B

doi

10.1016/j.jinorgbio.2007.04.016

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1739-47

issue

11-12

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(07)00087-6

journal_volume

101

pub_type

杂志文章

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