当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1-10, 1-16 fragments of human and mouse beta-amyloid peptide.

Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1-10, 1-16 fragments of human and mouse beta-amyloid peptide.

Abstract：

:The interactions of proteins with reactive oxygen species (ROS) may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages, and oxidation of the protein backbone resulting in protein fragmentation. In an attempt to elucidate the products of the metal-catalyzed oxidation of the human (H) and mouse (M) (1-10H), (1-10M), (1-16H) and (1-16M) fragments of beta-amyloid peptide, the high performance liquid chromatography (HPLC) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) methods and Cu(II)/H(2)O(2) as a model oxidizing system were employed. Peptide solution (0.50 mM) was incubated at 37 degrees C for 24 h with metal:peptide:H(2)O(2) molar ratio 1:1:1 for the (1-16H), (1-16M) fragments, and 1:1:2 for the (1-10H), (1-10M) peptides in phosphate buffer, pH 7.4. Oxidation targets for all peptide studied are the histidine residues coordinated to the metal ions. For the (1-16H) peptide are likely His(13) and/or His(14), and for the (1-16M) fragment His(6) and/or His(14), which are converted to 2-oxo-His. Metal-binding residue, the aspartic acid (D(1)) undergoes the oxidative decarboxylation and deamination to pyruvate. The cleavages of the peptide bonds by either the diamide or alpha-amidation pathways were also observed.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Kowalik-Jankowska T,Ruta M,Wiśniewska K,Łankiewicz L,Dyba M

doi

10.1016/j.jinorgbio.2004.03.001

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

940-50

issue

6

eissn

0162-0134

issn

1873-3344

pii

S0162013404000789

journal_volume

98

pub_type

杂志文章

相关文献

JOURNAL OF INORGANIC BIOCHEMISTRY文献大全
  • Biochemical characterization of phospholipases C from Coffea arabica in response to aluminium stress.

    abstract：:Signal transduction in plants determines their successful adaptation to diverse stress factors. Our group employed suspension cells to study the phosphoinositide pathway, which is triggered by aluminium stress. We investigated about members of the PI-specific phospholipase C (PLC) family and evaluated their transcript...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2019.110951

    authors： González-Mendoza VM,Sánchez-Sandoval ME,Munnik T,Hernández-Sotomayor SMT

    更新日期：2020-03-01 00:00:00

  • Prognostic significance of low serum levels of Clara cell phospholipid-binding protein in occupational aluminium neurotoxicity.

    abstract：:The relationship between respiratory and neurological effects of exposure to aluminium (Al) was investigated in a group of foundry workers exposed to Al at concentrations below the threshold limit value (TLV) binding in Poland (2.0 mg Al2O3 m(-3)). Neurological and neurophysiological parameters indicated subclinical e...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2005.06.027

    authors： Halatek T,Sinczuk-Walczak H,Rydzynski K

    更新日期：2005-09-01 00:00:00

  • Vanadocene complexes bearing N,N'-chelating ligands: Synthesis, structures and in vitro cytotoxic studies on the A549 lung adenocarcinoma cell line.

    abstract：:Ten new vanadocene complexes bearing N,N'-chelating ligands were prepared, characterized, and their cytotoxicity toward a panel of cancer cells was measured. Structures of four vanadocene compounds were determined by single crystal X-ray diffraction analysis. Complexes containing 1,2-bis(phenylimino)acenaphthene (bian...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2019.03.015

    authors： Melounková L,Machálková A,Havelek R,Honzíček J,Řezáčová M,Císařová I,Peterová E,Vinklárek J

    更新日期：2019-06-01 00:00:00

  • Electronic structures of azulene-fused porphyrins as seen by magnetic circular dichroism and TD-DFT calculations.

    abstract：:A combination of magnetic circular dichroism (MCD), electronic absorption spectroscopy and time-dependent density functional theory (TD-DFT) calculations has been used to investigate the electronic structure of azulene-fused pi-expanded porphyrins based primarily on the spectral properties of absorption bands in the n...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.09.012

    authors： Nakai K,Kurotobi K,Osuka A,Uchiyama M,Kobayashi N

    更新日期：2008-03-01 00:00:00

  • Hydroperoxide-dependent folic acid degradation by cytochrome c.

    abstract：:Folic acid is degraded by cytochrome c in the presence of hydrogen peroxide/tert-butyl hydroperoxide at the C9-N10 bond. The degradation is increased with increasing temperature. When guanidine HCl or benzoate are included in the reaction medium, the amount of folic acid degradation is enhanced. Catalase, formate, and...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(87)80058-2

    authors： Taher MM,Lakshmaiah N

    更新日期：1987-10-01 00:00:00

  • Stereochemical and biochemical aspects of some organoboron complexes of sulphur donor ligands.

    abstract：:Synthetic, structural and biochemical aspects of some organoboron complexes of sulphur containing ligands having ONS and SNNS donor systems have been described. The ligands were prepared by the condensation of 1-phenyl-1,3-butanedione, 2,4-pentanedione, diphenylethanedione, 2,3-butanedione, ethanedial and 1,4-benzened...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(90)84007-c

    authors： Singh VP,Singh RV,Tandon JP

    更新日期：1990-07-01 00:00:00

  • Biotinylated platinum(IV) complexes designed to target cancer cells.

    abstract：:Three biotinylated platinum(IV) complexes (1-3) were designed and synthesized. The resulting platinum(IV) complexes exhibited effective cytotoxicity against the tested cancer cell lines, especially complex 1, which was 2.0-9.6-fold more potent than cisplatin. These complexes were found to be rapidly reduced to their a...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2017.08.017

    authors： Zhao J,Hua W,Xu G,Gou S

    更新日期：2017-11-01 00:00:00

  • Differential binding of anions to the active site of Cu,Zn superoxide dismutase. A study of the Co,Zn enzyme derivative.

    abstract：:The reaction of N3- with Co,Zn superoxide dismutase, a good analogue of the native Cu,Zn enzyme, was studied in the presence and absence of phosphate, which is known to perturb the spectroscopic properties of the cobalt chromophore in the Co,Zn enzyme. EPR, NMR, and optical titrations demonstrated the formation of dif...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(88)80006-0

    authors： Desideri A,Paci M,Capo C,Calabrese L,Rotilio G

    更新日期：1988-08-01 00:00:00

  • Synthesis and biocidal activity of Zn(II) complexes of some 2,2'-substituted diphenylamines.

    abstract：:Binary as well as ternary complexes of Zn(II) with diphenylamine-2,2'-dicarboxylic acid (dpdc), diphenylamine-2-amino-2'-carboxylic acid (dpac), diphenylamine-2-hydroxy-2'-carboxylic acid (dphc), diphenylamine-2-mercapto-2'-carboxylic acid (dpmc), and N-(2-pyridino) anthranilic acid (npa) have been synthesized and cha...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(87)80029-6

    authors： Sharma RC,Parashar RK

    更新日期：1987-03-01 00:00:00

  • Synthesis, characterization, DNA binding, topoisomerase I inhibition and antiproliferation activities of three new functionalized terpyridine platinum(II) complexes.

    abstract：:Three new platinum(II) complexes with pendent morpholine were synthesized, namely complex 1 ([Pt(L)Cl]CF3SO3), complex 2 ([Pt(L)(NH3)](CF3SO3)2) and complex 3 ([Pt(L)(PPh3)](CF3SO3)2), where L = 4'-[4-(4-morpholinobutyloxy)phenyl]-2,2':6',2″-terpyridine and PPh3 = triphenylphosphine. The detailed molecular structures ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2018.12.003

    authors： Chai K,Kuang W,Lan Z,Zhang L,Jiang Y,Han T,Niu J,Wang J,Duan X

    更新日期：2019-03-01 00:00:00

  • Engineering and biological assessment of double core nanoplatform for co-delivery of hybrid fluorophores to human melanoma.

    abstract：:We investigated new development in photodynamic therapy (PDT), aiming at enhanced tumor selectivity and biocompatibility, which included application of a third-generation photosensitizing agent, i.e. xanthene-origin Rose Bengal (RB) co-encapsulated with up-converting NaYF4 nanoparticles (NPs) co-doped with lanthanide ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111088

    authors： Bazylińska U,Wawrzyńczyk D,Szewczyk A,Kulbacka J

    更新日期：2020-07-01 00:00:00

  • New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA.

    abstract：:A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positio...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2015.08.016

    authors： Iglesias BA,Barata JFB,Pereira PMR,Girão H,Fernandes R,Tomé JPC,Neves MGPMS,Cavaleiro JAS

    更新日期：2015-12-01 00:00:00

  • Strong poison revisited.

    abstract：:Selenium in the form of selenocysteine plays an essential role in a number of proteins, but its role in non-enzymatic biochemistry is also important. In this short review we discuss the interactions between inorganic selenium, arsenic and mercury under physiological conditions, especially in the presence of glutathion...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.jinorgbio.2007.06.008

    authors： Prince RC,Gailer J,Gunson DE,Turner RJ,George GN,Pickering IJ

    更新日期：2007-11-01 00:00:00

  • Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450(scc) (CYP11A1).

    abstract：:The redox active iron-sulfur center of bovine adrenodoxin is coordinated by four cysteine residues in positions 46, 52, 55 and 92 and is covered by a loop containing the residues Glu-47, Gly-48, Thr-49, Leu-50 and Ala-51. In plant-type [2Fe-2S] ferredoxins, the corresponding loop consists of only four amino acids. The...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(02)00463-4

    authors： Zöllner A,Hannemann F,Lisurek M,Bernhardt R

    更新日期：2002-09-20 00:00:00

  • Structural and biological aspects of copper (II) complexes with 2-methyl-3-amino-(3H)-quinazolin-4-one.

    abstract：:A series of new copper (II) complexes with 2-methyl-3-amino(3H)-quinazolin-4-one (MAQ) and various anions (Cl-, Br-, ClO(-)4, NO(-)3, SCN-, and SO(2-)4 was prepared. Their structures and properties were characterized by elemental analysis, IR, UV-Vis and ESR spectroscopy, molar conductivity, and magnetic moment measur...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(96)00122-5

    authors： Ramadan AM

    更新日期：1997-02-15 00:00:00

  • Mimic models of peroxidase--kinetic studies of the catalytic oxidation of hydroquinone by H2O2.

    abstract：:The reactions of hydroquinone with hydrogen peroxide catalyzed by transition metal ions Cu2+, Fe2+, Fe3+, Co2+ and Mn2+ were investigated in aqueous solution at 25 degrees C. Two copper (II) complexes (bis(dimethylglyoxime) copper(II) and 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-dienatocopper(II)...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2004.09.019

    authors： Meng XG,Guo Y,Hu CW,Zeng XC

    更新日期：2004-12-01 00:00:00

  • Catechol amide derivatized polyhydroxylated fullerene as potential chelating agents of radionuclides: Synthesis, reactive oxygen species scavenging, and cytotoxic studies.

    abstract：:Radionuclide internal contamination can induce chemical and radioactive intoxication and produce harmful free radicals in vivo. At present, administration of chelating agents is the most effective treatment against nuclide contamination. However, traditional studies on chelating agents have ignored the damage caused b...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2019.110921

    authors： Zheng T,Wan X,Zhang Q,Jin B,Peng RF

    更新日期：2020-02-01 00:00:00

  • Dinuclear copper-dioxygen intermediates supported by polyamine ligands.

    abstract：:Reactivity of the dicopper(I) and dicopper(II) complexes supported by novel polyamine ligands L1 (1,11-bis(6-methylpyridin-2-yl)-2,6,10-triaza-2,6,10-tribenzylundecane) and L2 (5-benzyl-1,9-bis(6-methylpyridin-2-yl)-2,8-bis(6-methylpyridin-2-ylmethyl)-2,5,8-triazanonane) towards O(2) and H(2)O(2), respectively, has be...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2003.11.009

    authors： Teramae S,Osako T,Nagatomo S,Kitagawa T,Fukuzumi S,Itoh S

    更新日期：2004-05-01 00:00:00

  • Biological evaluation of water soluble arene Ru(II) enantiomers with amino-oxime ligands.

    abstract：:New water soluble, enantiopure arene ruthenium compound SRuSN-(1R,4S)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (Bn = benzyl, 1a') has been synthesized. The novel compound along with that previously described RRuRN-(1S,4R)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (1a) was evaluated by polarimetry, ultra-violet and circular dichr...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2018.02.018

    authors： de la Cueva-Alique I,Sierra S,Muñoz-Moreno L,Pérez-Redondo A,Bajo AM,Marzo I,Gude L,Cuenca T,Royo E

    更新日期：2018-06-01 00:00:00

  • Catalytic properties of thioredoxin immobilized on superparamagnetic nanoparticles.

    abstract：:Thioredoxin (Trx1), a very important protein for regulating intracellular redox reactions, was immobilized on iron oxide superparamagnetic nanoparticles previously coated with 3-aminopropyltriethoxysilane (APTS) via covalent coupling using the EDC (1-ethyl-3-{3-dimethylaminopropyl}carbodiimide) method. The system was ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2011.02.006

    authors： Netto CG,Nakamatsu EH,Netto LE,Novak MA,Zuin A,Nakamura M,Araki K,Toma HE

    更新日期：2011-05-01 00:00:00

  • Comments on the through-space singlet energy transfers and energy migration (exciton) in the light harvesting systems.

    abstract：:Recent findings on the photophysical investigations of several cofacial bisporphyrin dyads for through space singlet and triplet energy transfers raised several serious questions about the mechanism of the energy transfers and energy migration in the light harvesting devices, notably LH II, in the heavily studied purp...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.09.011

    authors： Harvey PD,Stern C,Gros CP,Guilard R

    更新日期：2008-03-01 00:00:00

  • Effective cleavage of phosphodiester promoted by the zinc(II) and copper(II) inclusion complexes of β-cyclodextrin.

    abstract：:To construct the model of metallohydrolase, two inclusion complexes [MLCl2(β-CD)] (1, M=Zn(II); 2, M=Cu(II); L=N,N'-bis(2-pyridylmethyl)amantadine; β-CD=β-cyclodextrin) were synthesized by mixing β-CDs with the pre-synthesized complexes G1, [ZnLCl2] and G2, [CuLCl2]. Structures of G1, G2, 1 and 2 were characterized by...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.07.011

    authors： Zhou YH,Chen LQ,Tao J,Shen JL,Gong DY,Yun RR,Cheng Y

    更新日期：2016-10-01 00:00:00

  • Cobalt-mediated generation of reactive oxygen species and its possible mechanism.

    abstract：:Electron spin resonance spin trapping was utilized to investigate free radical generation from cobalt (Co) mediated reactions using 5,5-dimethyl-1-pyrroline (DMPO) as a spin trap. A mixture of Co with water in the presence of DMPO generated 5,5-dimethylpyrroline-(2)-oxy(1) DMPOX, indicating the production of strong ox...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(98)10022-3

    authors： Leonard S,Gannett PM,Rojanasakul Y,Schwegler-Berry D,Castranova V,Vallyathan V,Shi X

    更新日期：1998-07-01 00:00:00

  • Biotechnological approach to induce human fibroblast apoptosis using superparamagnetic iron oxide nanoparticles.

    abstract：:Cancer-Associated Fibroblasts (CAFs) contribute to tumour progression and have received significant attention as a therapeutic target. These cells produce growth factors, cytokines and chemokines, stimulating cancer cell proliferation and inhibiting their apoptosis. Recent advances in drug delivery have demonstrated a...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111017

    authors： Ferraz FS,López JL,Lacerda SMSN,Procópio MS,Figueiredo AFA,Martins EMN,Guimarães PPG,Ladeira LO,Kitten GT,Dias FF,Domingues RZ,Costa GMJ

    更新日期：2020-05-01 00:00:00

  • Novel short-chain analogues of somatostatin as ligands for Cu(II) ions. Role of the metal ion binding on the spatial structure of the ligand.

    abstract：:In this paper we present the studies on coordination abilities of two short-chain analogues of somatostatin with free N-terminal and protected amino group towards copper (II) ions. The octreotide is the most popular analogue of the somatostatin (peptide hormone) used in medicine. Somatostatin analogues are used in dia...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.08.023

    authors： Marciniak A,Cebrat M,Czyżnikowska Ż,Brasuń J

    更新日期：2012-12-01 00:00:00

  • Metalloporphyrin mediated DNA cleavage by a low concentration of HaeIII restriction enzyme.

    abstract：:The plasmid DNA scission by the restriction enzyme HaeIII was investigated in the presence of tetrakis(1-methylpyridinium-4-yl)porphyrin (H2TMPyP) and its manganese(III), iron(III), nickel(II), cobalt(III) and zinc(II) derivatives. The effect of metalloporphyrins on plasmid DNA cleavage was ascertained by gel electrop...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(00)00067-2

    authors： Tabata M,Nakajima K,Nyarko E

    更新日期：2000-03-01 00:00:00

  • Reprint of "Anticancer activity of hydroxy- and sulfonamide-azobenzene platinum(II) complexes in cisplatin-resistant ovarian cancer cells".

    abstract：:The syntheses of three platinum(II) complexes bearing sulfonamide-((E)-2-(4-methylphenylsulfonamido)-2',6'-difluoroazobenzene, HL1) and hydroxy-azo-2,6-difluorobenzene ((E)-2-((2,6-difluorophenyl)diazenyl)phenol, HL2) bidentate ligands is described. These complexes, [Pt(L1)(DMSO)Cl] (1), [Pt(L2)(DMSO)Cl] (2), and [Pt(...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2017.07.035

    authors： Samper KG,Marker SC,Bayón P,MacMillan SN,Keresztes I,Palacios Ò,Wilson JJ

    更新日期：2017-12-01 00:00:00

  • The formation and nature of the mixed valence copper-D-penicillamine-chloride cluster in aqueous solution and its relevance to the treatment of Wilson's disease.

    abstract：:Complex formation between D-penicillamine (Pen) and copper(II) ions has been studied under simulated physiological conditions in both the presence and absence of the blood plasma constituents albumin, alanine, histidine, and zinc(II). Chromatographic and uv/vis and electron spin resonance (esr) spectroscopic methods w...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(00)80020-3

    authors： Laurie SH,Prime DM

    更新日期：1979-11-01 00:00:00

  • The crystal structure of the CopC protein from Pseudomonas fluorescens reveals amended classifications for the CopC protein family.

    abstract：:The bacterial CopC family of proteins are periplasmic copper binding proteins that act in copper detoxification. These proteins contain Cu(I) and/or Cu(II) binding sites, with the family that binds Cu(II) only the most prevalent, based on sequence analyses. Here we present three crystal structures of the CopC protein ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2019.03.007

    authors： Udagedara SR,Wijekoon CJK,Xiao Z,Wedd AG,Maher MJ

    更新日期：2019-06-01 00:00:00

  • Study on nucleic acid (CT-DNA and yeast tRNA) binding behaviors and cytotoxic properties of a heterodinuclear Ru(II)-Co(III) polypyridyl complex.

    abstract：:A heterodinuclear (Ru(II), Co(III)) metal polypyridyl complex [(phen)(2)Ru(bpibH(2))Co(phen)(2)](5+) {phen = 1,10-phenanthroline, bpibH(2) = 1,4-bis([1,10]phebanthroline-[5,6-d]imidazol-2-yl)-benzene} has been designed and synthesized. The comparative study on the interactions of the Ru(II)-Co(III) complex with calf t...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2010.08.006

    authors： Liang X,Zou X,Tan L,Zhu W

    更新日期：2010-12-01 00:00:00