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The copper(II) binding properties of the cyclic peptide c(HGHK).

Abstract：

:The new cyclic tetrapeptide c(HGHK) was synthesised in the solid phase and its complexes with copper(II) were studied in aqueous solution at various pH values by means of potentiometric and spectroscopic methods (UV, EPR, CD). Six mononuclear coordination species were clearly identified within the pH range 3-11. Spectroscopic data strongly suggest sequential formation of N, 2N, 3N and 4N equatorial donor sets around the copper(II) centre from the lowest to the highest pH, involving both imidazole nitrogens and amide nitrogens. A detailed comparison with the copper(II) binding properties of HGHG and Ac-HGHG ligands is also reported.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Brasun J,Gabbiani C,Ginanneschi M,Messori L,Orfei M,Swiatek-Kozlowska J

doi

10.1016/j.jinorgbio.2004.09.007

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

2016-21

issue

12

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(04)00262-4

journal_volume

98

pub_type

杂志文章

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