当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Cyclic tetranuclear half-sandwich ruthenium(II) complexes with 4,7-phenanthroline and hydroxo bridges: crystal structure, solution behaviour and binding to nucleosides.

Cyclic tetranuclear half-sandwich ruthenium(II) complexes with 4,7-phenanthroline and hydroxo bridges: crystal structure, solution behaviour and binding to nucleosides.

Abstract：

:The reaction between [(eta(6)-p-cymene)Ru(H2O)3]X2 and 4,7-phenanthroline (phen) leads to the formation of the rectangular tetranuclear complexes [(eta(6)-p-cymene)4Ru4(mu-4,7-phen-N4,N7)(2)(mu-OH)4]X4 (X=NO3, 1a; SO3CF3, 1b) which have been structurally characterised by X-ray crystallography. 1H NMR spectroscopic studies suggest the presence of a partially dissociated dinuclear species of type [(eta6-p-cymene)2Ru2(mu-4,7-phen-N4,N7)(solv)4]4+ in equilibrium with the tetranuclear cyclic species found in the solid state. The temperature effect for this equilibrium was studied by variable temperature 1H NMR experiments in D2O and MeOD. The results reveal that the proportion of the tetranuclear species increases with the polarity of the solvent which favour stacking interactions between the phenanthroline moieties. In addition, the reactivity of the tetranuclear species towards the nucleosides guanosine (Guo), cytidine (Cyt), 2'-deoxythymidine (Thy) and 2'-deoxyadenosine (dAdo) has been monitored by (1)H NMR as a potential model for the interaction of the 1 species with the probable DNA target. The results reveal that the 1 systems are able to bind the nucleobases endocyclic nitrogen atoms of Guo Cyt, and dAdo.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Galindo MA,Quirós M,Romero MA,Navarro JA

doi

10.1016/j.jinorgbio.2007.11.009

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

1025-32

issue

5-6

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(07)00322-4

journal_volume

102

pub_type

杂志文章

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