Synthesis and characterization of new chromium(III), vanadium(IV), and titanium(III) complexes with biologically active isonicotinic acid hydrazide.

Abstract:

:New complexes of the type [Cr(INH)2Cl2]Cl.2H2O, VO(INH)2Cl2 and TiO(INH)2Cl, where INH = isonicotinic acid hydrazide, have been prepared. The complexes were characterized by infrared and UV-vis spectroscopy, proton nuclear magnetic resonance (NMR) and elemental analyses, molar conductivity and x-ray powder diffraction measurements. For the Cr(III)-complex, the ligand was coordinated through its carbonyl group and amino nitrogen atom; for V(IV)-complex and Ti(III)-complex, the ligand was coordinated through its carbonyl oxygen and heterocyclic nitrogen, respectively. Octahedral geometry has been proposed for all the complexes. The complexes of Cr(III) and Ti(III) showed significant tuberculostatic activity.

journal_name

J Inorg Biochem

authors

Pin Y,Zhang XP

doi

10.1016/0162-0134(89)80030-3

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

61-8

issue

1

eissn

0162-0134

issn

1873-3344

pii

0162-0134(89)80030-3

journal_volume

37

pub_type

杂志文章
  • Identification of Trp106 as the tryptophanyl radical intermediate in Synechocystis PCC6803 catalase-peroxidase by multifrequency Electron Paramagnetic Resonance spectroscopy.

    abstract::The reactive intermediates formed in the catalase-peroxidase from Synechocystis PCC6803 upon reaction with peroxyacetic acid, and in the absence of peroxidase substrates, are the oxoferryl-porphyrin radical and two subsequent protein-based radicals that we have previously assigned to a tyrosyl (Tyr()) and tryptophanyl...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2006.02.009

    authors: Jakopitsch C,Obinger C,Un S,Ivancich A

    更新日期:2006-05-01 00:00:00

  • Antiproliferative activity of Pt(IV)-bis(carboxylato) conjugates on malignant pleural mesothelioma cells.

    abstract::The bifunctional Pt(IV) conjugate cis,cis,trans-diamminedichloridobis(valproato)platinum(IV), based on the cisplatin square-plane with two axial valproato (2-propylpentanoate, VPA) ligands, has been re-synthesized with a modified procedure and its biological activity was compared with that of its isomer cis,cis,trans-...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2013.09.003

    authors: Alessio M,Zanellato I,Bonarrigo I,Gabano E,Ravera M,Osella D

    更新日期:2013-12-01 00:00:00

  • Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant.

    abstract::The zinc coordination sphere in prokaryotic zinc finger domain is extremely versatile and influences the stability and the folding property of the domain. Of a particular interest is the fourth zinc coordinating position, which is frequently occupied by two successive histidines, both able to coordinate the metal ion....

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2013.10.016

    authors: Palmieri M,Russo L,Malgieri G,Esposito S,Baglivo I,Rivellino A,Farina B,de Paola I,Zaccaro L,Milardi D,Isernia C,Pedone PV,Fattorusso R

    更新日期:2014-02-01 00:00:00

  • Coordination of cellular iron metabolism by post-transcriptional gene regulation.

    abstract::Maintenance of cellular iron homeostasis demands the coordination of iron uptake, intracellular storage, and utilization. Recent investigations suggest that a single genetic regulatory system orchestrates the expression of proteins with central importance for all three aspects of cellular iron metabolism at the level ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章,评审

    doi:10.1016/0162-0134(92)84064-t

    authors: Kühn LC,Hentze MW

    更新日期:1992-08-15 00:00:00

  • Kinetics of reaction of DNA-bound Fe(III)bleomycin with ascorbate: interplay of specific and non-specific binding.

    abstract::The aerobic redox reaction of Fe(III)bleomycin (Blm) and ascorbate was examined in the absence of DNA and in the presence of 7.5 and 25 calf thymus DNA base pairs per-drug molecule, in order to investigate the effect of DNA binding on the properties of FeBlm activation and DNA strand cleavage. Under these successive c...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(02)00368-9

    authors: Li W,Antholine WE,Petering DH

    更新日期:2002-05-21 00:00:00

  • Ternary oxovanadium(IV) complexes with amino acid-Schiff base and polypyridyl derivatives: synthesis, characterization, and protein tyrosine phosphatase 1B inhibition.

    abstract::To investigate the structure-activity relationship of vanadium complexes in inhibiting protein tyrosine phosphatase1B (PTP1B), eight mixed-ligand oxovanadium(IV) complexes, [V(IV)O(SalAla)(NN)] (H(2)SalAla for salicylidene alanine, NN for N,N'-donor heterocyclic base, namely, 2,2'-bipyridine (bpy, 1), 1,10-phenanthrol...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2011.07.008

    authors: Lu L,Yue J,Yuan C,Zhu M,Han H,Liu Z,Guo M

    更新日期:2011-10-01 00:00:00

  • Carbonic anhydrase inhibitors. Part 11. Coordination compounds of heterocyclic sulfonamides with lanthanides are potent inhibitors of isozymes I and II.

    abstract::A number of 22 lanthanide-containing coordination compounds of sulfonamides 2 and 3 were prepared and characterized by elemental analysis and spectroscopic data. The new compounds proved to be highly potent inhibitors of isozymes I and II of carbonic anhydrase. ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/0162-0134(93)85019-5

    authors: Supuran CT,Manole G,Andruh M

    更新日期:1993-02-01 00:00:00

  • A proximal tryptophan in NO synthase controls activity by a novel mechanism.

    abstract::The heme of neuronal nitric oxide synthase (nNOS) participates in O2 activation but also binds self-generated NO, resulting in reversible feedback inhibition. We utilized mutagenesis to investigate if a conserved tryptophan residue (Trp409), which engages in pi-stacking with the heme and hydrogen bonds to its axial cy...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(00)00176-8

    authors: Adak S,Stuehr DJ

    更新日期:2001-02-01 00:00:00

  • Protecting or promoting effects of spermine on DNA strand breakage induced by iron or copper ions as a function of metal concentration.

    abstract::Polyamines are ubiquitous polycations that participate in cellular processes such as growth, differentiation and cell death. Among the different functions ascribed to these organic cations, the polyamine spermine is known to protect DNA from the damage produced by reactive oxygen species (ROS) generated by different a...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2005.07.005

    authors: Pedreño E,López-Contreras AJ,Cremades A,Peñafiel R

    更新日期:2005-10-01 00:00:00

  • Hydroperoxide-dependent folic acid degradation by cytochrome c.

    abstract::Folic acid is degraded by cytochrome c in the presence of hydrogen peroxide/tert-butyl hydroperoxide at the C9-N10 bond. The degradation is increased with increasing temperature. When guanidine HCl or benzoate are included in the reaction medium, the amount of folic acid degradation is enhanced. Catalase, formate, and...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/0162-0134(87)80058-2

    authors: Taher MM,Lakshmaiah N

    更新日期:1987-10-01 00:00:00

  • Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships.

    abstract::A previous evaluation of the insulin-like activity of three 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes raised questions about structure/activity relationships, namely the influence of the hydrophilic/lipophilic balance of the complex and the capacity of the ligand to stabilize the +4 oxidation state of vanad...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2008.12.019

    authors: Rangel M,Amorim MJ,Nunes A,Leite A,Pereira E,de Castro B,Sousa C,Yoshikawa Y,Sakurai H

    更新日期:2009-04-01 00:00:00

  • Improved separation of the curcuminoids, syntheses of their rare earth complexes, and studies of potential antiosteoporotic activity.

    abstract::The first reported homogenous rare earth curcumin (HCurc; ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione)) complexes with the formula ML3, where M(3+) is Eu(III), Gd(III) or Lu(III), were synthesized and characterized by mass spectrometry, infrared spectroscopy and, in the case of the lutetium co...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2013.12.004

    authors: Mawani Y,Orvig C

    更新日期:2014-03-01 00:00:00

  • Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF).

    abstract::Human metallothionein-3 (hMT3), also named as human neuronal growth inhibitory factor (hGIF), can inhibit the outgrowth of embryonic cortical neurons in the presence of brain extracts. In order to systematically study the structure-property-reactivity-function relationship of hGIF, our laboratory designed a series of ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jinorgbio.2008.07.007

    authors: Ding ZC,Zheng Q,Cai B,Ni FY,Yu WH,Teng XC,Gao Y,Liu F,Chen D,Wang Y,Wu HM,Sun HZ,Zhang MJ,Tan XS,Huang ZX

    更新日期:2008-11-01 00:00:00

  • Synthesis, characterization, and structure-activity relationship of the antimicrobial activities of dinuclear N-heterocyclic carbene (NHC)-silver(I) complexes.

    abstract::The three dinuclear silver(I) complexes of N-heterocyclic carbene (NHC) ligands, [Ag2(L-1a)](PF6)2·2CH3CN (Ag-1a), [Ag2(L-2)2](PF6)2·H2O (Ag-2), and [Ag2(L-4)2](PF6)2·2CH3CN (Ag-4), were synthesized by reactions of Ag2O with the corresponding PF6- salt of the NHC precursors indicated as H4L-1(PF6)4, H2L-2(PF6)2, and H...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2016.06.031

    authors: Sakamoto R,Morozumi S,Yanagawa Y,Toyama M,Takayama A,Kasuga NC,Nomiya K

    更新日期:2016-10-01 00:00:00

  • Influence of the introduction of a triphenylphosphine group on the anticancer activity of a copper complex.

    abstract::Aiming at obtaining new copper complexes with good cytotoxicity against cancer cells, triphenylphosphine (TPP) was introduced to obtain insight into the influence of the co-ligands. In this paper, two copper complexes, Cu(2-pbmq)(CH3OH)Br2 (1) and [Cu(2-pbmq)(TPP)Br]2 (2) were designed, synthesized, and characterized ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2020.111102

    authors: Li S,Zhao J,Guo Y,Mei Y,Yuan B,Gan N,Zhang J,Hu J,Hou H

    更新日期:2020-09-01 00:00:00

  • Molecular recognition patterns of 2-aminopurine versus adenine: a view through ternary copper(II) complexes.

    abstract::In contrast to the comprehensive structural information about metal complexes with adenine, the corresponding to its isomer 2-aminopurine (H2AP) is extremely poor. With the aim to rationalize the metal binding pattern of H2AP, we report the molecular and/or crystal structure of four novel compounds with various iminod...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2011.05.009

    authors: Domínguez-Martín A,Choquesillo-Lazarte D,González-Pérez JM,Castiñeiras A,Niclós-Gutiérrez J

    更新日期:2011-08-01 00:00:00

  • Future perception in P450 research.

    abstract::Cytochrome P450 (P450) of eukaryotes and prokaryotes diversified remarkably during the long course of their evolution. Since the diversification of P450 was the consequence of the adaptation of various living organisms to diverse environmental changes, the catalytic activities and physiological functions of the P450s ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2018.06.002

    authors: Omura T

    更新日期:2018-09-01 00:00:00

  • The metal- and DNA-binding activities of Helicobacter pylori NikR.

    abstract::The pathogenic bacteria Helicobacter pylori require nickel as a cofactor of the enzymes urease and hydrogenase. One of the proteins that controls nickel homeostasis in this organism is Helicobacter pylori NikR (HpNikR), a homologue of nickel-dependent transcription factors from other organisms, which regulates the exp...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2005.10.014

    authors: Abraham LO,Li Y,Zamble DB

    更新日期:2006-05-01 00:00:00

  • The copper(II) binding properties of the cyclic peptide c(HGHK).

    abstract::The new cyclic tetrapeptide c(HGHK) was synthesised in the solid phase and its complexes with copper(II) were studied in aqueous solution at various pH values by means of potentiometric and spectroscopic methods (UV, EPR, CD). Six mononuclear coordination species were clearly identified within the pH range 3-11. Spect...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2004.09.007

    authors: Brasun J,Gabbiani C,Ginanneschi M,Messori L,Orfei M,Swiatek-Kozlowska J

    更新日期:2004-12-01 00:00:00

  • Synthesis, structure and biomimetic properties of Cu(II)-Cu(II) and Cu(II)-Zn(II) binuclear complexes: possible models for the chemistry of Cu-Zn superoxide dismutase.

    abstract::Four imidazolate-bridged binuclear copper(II)-copper(II) and copper(II)-zinc(II) complexes viz., [(Bipy)(2)Cu-Im-Cu(Bipy)(2)](ClO(4))(3).CH(3)OH, [(Phen)(2)Cu-Im-Cu(Phen)(2)](BF(4))(3).2CH(3)OH, [(Bipy)(2)Cu-Im-Zn(Bipy)(2)](BF(4))(3), and [(Phen)(2)Cu-Im-Zn(Phen)(2)](BF(4))(3), (Bipy=2,2'-Bipyridyl, Phen=1-10-Phenanth...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2004.11.023

    authors: Patel RN,Singh N,Shukla KK,Gundla VL,Chauhan UK

    更新日期:2005-02-01 00:00:00

  • What is wrong with aluminium? The J.D. Birchall Memorial Lecture.

    abstract::Aluminium chemistry has features in common with two other groups of elements: (1) divalent magnesium and calcium, and (2) trivalent chromium and iron. The essential differences between the first group and aluminium are explored and it is shown that the much higher acidity of aluminium makes it such a powerful competit...

    journal_title:Journal of inorganic biochemistry

    pub_type:

    doi:10.1016/s0162-0134(99)00118-x

    authors: Williams RJ

    更新日期:1999-08-30 00:00:00

  • Metal-ion speciation in blood plasma incorporating the bisphosphonate, 1-hydroxy-4-aminopropilydenediphosphonate (APD), in therapeutic radiopharmaceuticals.

    abstract::In the quest for more effective pain palliation radiopharmaceuticals for metastatic bone cancer, this paper relates results obtained with 166Ho complexed to the bone-seeking bisphosphonate, 1-hydroxy-4-aminopropililydenediphosphonate (APD). APD is itself a bone cancer pain palliation agent and this work was therefore ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(99)00027-6

    authors: Zeevaart JR,Jarvis NV,Louw WK,Jackson GE,Cukrowski I,Mouton CJ

    更新日期:1999-04-01 00:00:00

  • In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes.

    abstract::Herein we report the in-vivo characterisation and metabolic changes in Galleria mellonella larvae to a series of bis-chelate copper(II) phenanthroline-phenazine cationic complexes of [Cu(phen)2]2+ (Cu-Phen), [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen) and [Cu(DPPZ)(Phen)]2+ (Cu-DPPZ-Phen) (where phen = 1,10-phenanthroline, DPQ = ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2018.05.020

    authors: Rochford G,Molphy Z,Browne N,Surlis C,Devereux M,McCann M,Kellett A,Howe O,Kavanagh K

    更新日期:2018-09-01 00:00:00

  • Physico-chemical properties of MnII complexes formed with cis- and trans-DO2A: thermodynamic, electrochemical and kinetic studies.

    abstract:SYNOPSIS:MnII complexes formed with cis- and trans-DO2A (DO2A=1,4,7,10-tetraazacyclododecane-1,4 (or 1,7) -diacetic acid) chelators were investigated by pH-potentiometry, 1H relaxometry, UV-vis spectrophotometry and cyclic voltammetry. The physico-chemical characteristics of MnII complexes of these structure isomers do...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2016.07.018

    authors: Garda Z,Forgács A,Do QN,Kálmán FK,Timári S,Baranyai Z,Tei L,Tóth I,Kovács Z,Tircsó G

    更新日期:2016-10-01 00:00:00

  • Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes.

    abstract::The reaction of zinc(II) chloride, cadmium(II) chloride and bromide with 3-thiophene aldehyde thiosemicarbazone leads to the formation of a series of new complexes. They have been characterized by spectroscopic studies: infrared, (1)H NMR, and electronic spectra. The crystal structures of the compound [ZnCl(2)(3TTSCH)...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2009.11.012

    authors: Alomar K,Landreau A,Kempf M,Khan MA,Allain M,Bouet G

    更新日期:2010-04-01 00:00:00

  • In vitro study of percutaneous absorption of aluminum from antiperspirants through human skin in the Franz™ diffusion cell.

    abstract::Aluminum salts such as aluminum chlorohydrate (ACH) are known for use as an active antiperspirant agent that blocks the secretion of sweat. A local case report of hyperaluminemia in a woman using an aluminum-containing antiperspirant for 4 years raises the problem of transdermal absorption of aluminum (Al). Only a ver...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2012.02.013

    authors: Pineau A,Guillard O,Favreau F,Marrauld A,Fauconneau B

    更新日期:2012-05-01 00:00:00

  • Synthesis, characterization, interaction with DNA and cytotoxicity of the new potential antitumour drug cis-K[Ru(eddp)Cl(2)].

    abstract::The new potential antitumour soluble drug K[Ru(eddp)Cl(2)].3H(2)O, (eddp=ethylenediamine-N,N'-di-3-propionate) has been isolated and characterized. The analysis of the interaction of this complex with pBR322 plasmid DNA by circular dichroism spectroscopy shows that the ruthenium complex initially induces alteration of...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/s0162-0134(03)00281-2

    authors: Grguric-Sipka SR,Vilaplana RA,Pérez JM,Fuertes MA,Alonso C,Alvarez Y,Sabo TJ,González-Vílchez F

    更新日期:2003-10-01 00:00:00

  • Vanadium-catalyzed chlorination under molecular oxygen.

    abstract::A catalytic chlorination of ketones was performed by using a vanadium catalyst in the presence of Bu4NI and AlCl3 under atmospheric molecular oxygen. This catalytic chlorination could be applied to the chlorination of alkenes to give the corresponding vic-dichlorides. AlCl3 was found to serve as both a Lewis acid and ...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2015.01.015

    authors: Moriuchi T,Fukui Y,Kato S,Kajikawa T,Hirao T

    更新日期:2015-06-01 00:00:00

  • The interesting DNA-binding properties of three novel dinuclear Ru(II) complexes with varied lengths of flexible bridges.

    abstract::Three binuclear Ru(II) complexes with two [Ru(bpy)(2)(pip)](2+)-based subunits {where bpy=2,2'-bipyridine and pip=2-phenylimidazo[4,5-f][1,10]phenanthroline} being linked by varied lengths of flexible bridges, were synthesized and characterized by (1)H NMR, elemental analysis, UV-visible (UV-vis) and photoluminescence...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2010.12.004

    authors: Ju CC,Zhang AG,Yuan CL,Zhao XL,Wang KZ

    更新日期:2011-03-01 00:00:00

  • Interaction of iron(II)-heme and artemisinin with a peptide mimic of Plasmodium falciparum HRP-II.

    abstract::The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a...

    journal_title:Journal of inorganic biochemistry

    pub_type: 杂志文章

    doi:10.1016/j.jinorgbio.2007.04.016

    authors: Accardo A,Laurent SA,Mazarguil H,Meyer M,Robert A,Meunier B

    更新日期:2007-11-01 00:00:00