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A 1H nmr study of the interaction of aurothiomalate ("Myocrisin") with human red blood cells in vitro.

Abstract：

:The results of 1H spin-echo Fourier transform (SEFT) nuclear magnetic resonance (nmr) experiments suggest that some aurothiomalate binds intracellular glutathione (GSH) when added to suspensions of red cells in vitro. When added to red cell lysates, a specific binding of gold to cysteine of GSH is observed together with release of thiomalate. Gold binding to GSH can be reversed by addition of dimercaptopropanol sulfonate. Spectra are compared to those of an aurothiomalate-GSH model system. The relationship of these findings to the mechanism of action of Myocrisin is discussed.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Otiko G,Razi MT,Sadler PJ,Isab AA,Rabenstein DL

doi

10.1016/0162-0134(83)85027-2

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

227-35

issue

3

eissn

0162-0134

issn

1873-3344

pii

0162-0134(83)85027-2

journal_volume

19

pub_type

杂志文章

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