当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate.

Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate.

Abstract：

:Tetrathiomolybdate (TTM) is a powerful and selective copper (Cu) chelator that is used as a therapeutic agent for Wilson disease. TTM is the sole agent that can remove Cu bound to metallothionein (MT) in the livers of Long-Evans rats with a cinnamon-like coat color (LEC rats). However, the administration of excess TTM causes the deposition of Cu and molybdenum (Mo) in the liver. In the present study, the effect of hepatic glutathione (GSH) depletion on the removal of Cu from the livers of LEC rats was evaluated to establish an effective therapy by TTM. Pretreatment with l-buthionine sulfoximine (BSO), a depletor of GSH in vivo, reduced the amounts of Cu and Mo excreted into both the bile and the bloodstream, and increased the amounts of Cu and Mo deposited in the livers of LEC rats in the form of an insoluble complex 4h after the TTM injection. The results suggest that GSH depletion creates an oxidative environment in the livers of LEC rats, and the oxidative environment facilitates the insolubilization of Cu and Mo in the livers of LEC rats after the TTM injection. Therefore, the effect of TTM on the removal of Cu from the liver was reduced in the oxidized condition. Wilson disease patients and LEC rats develop liver injury caused by oxidative damage. From a clinical viewpoint, increasing in the GSH concentration is expected to enhance the effect of TTM.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Ogra Y,Miyayama T,Anan Y

doi

10.1016/j.jinorgbio.2010.04.001

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

858-62

issue

8

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(10)00091-7

journal_volume

104

pub_type

杂志文章

相关文献

JOURNAL OF INORGANIC BIOCHEMISTRY文献大全
  • New copper(I) and heteronuclear copper(I)-ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity.

    abstract：:A new family of copper(I) complexes of general formula [Cu(dppe)(NN)]+ have been synthesized and fully characterized, with dppe=1.2-bis(diphenylphosphino)ethane and NN representing several bidentate heteroaromatic ligands: 2,2'-bipy=2.2'-bipyridine (1), Me2bpy=4.4'-dimethyl-2,2'-bipyridine (2), dpytz=3-(2-pyridyl)-5,6...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2017.01.007

    authors： Lopes J,Alves D,Morais TS,Costa PJ,Piedade MF,Marques F,Villa de Brito MJ,Helena Garcia M

    更新日期：2017-04-01 00:00:00

  • HENRYK - An endless source of metal coordination surprises.

    abstract：:The basic knowledge about biological inorganic chemistry, thermodynamics and metal binding sites of metalloproteins is crucial for the understanding of their metal binding-structure-function relationship. Metal-peptide complexes are useful and commonly used models of metal-enzyme active sites, among which copper and z...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.02.030

    authors： Kołkowska P,Hecel A,Kędzierska D,Ostrowska M,Walencik PK,Wątły J,Zdyb K,Spodzieja M,Rodziewicz-Motowidło S,Potocki S,Łuczkowski M,Gumienna-Kontecka E,Rowińska-Żyrek M

    更新日期：2016-10-01 00:00:00

  • Synthesis, characterization and antitumoral activity of new cobalt(II)complexes: Effect of the ligand isomerism on the biological activity of the complexes.

    abstract：:The synthesis, physico-chemical characterization and cytotoxicity against five human tumoral cell lines (THP-1, U937, Molt-4, Colo205 and H460) of three new cobalt(II) coordination compounds are reported (i.e. Co(HL1)Cl (1), Co(HL2)Cl (2) and [Co(HL3)Cl]0.0.5 (CH3)2CHOH (3)). H2L2 (2-{[[2-hydroxy-3-(1-naphthyloxy)prop...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.05.003

    authors： Morcelli SR,Bull ÉS,Terra WS,Moreira RO,Borges FV,Kanashiro MM,Bortoluzzi AJ,Maciel LL,de A Almeida JC,Júnior AH,Fernandes C

    更新日期：2016-08-01 00:00:00

  • The metal complexes of N-confused porphyrin as heme model compounds.

    abstract：:Recently, metal complexes of the isomers and analogs of porphyrin have become important model compounds for heme enzymes and proteins. While the chemistry of metalloporphyrins as heme models still attracts attention, the isomers and analogs of porphyrins provide insight into the biological choice of porphine as the ma...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.jinorgbio.2006.01.016

    authors： Harvey JD,Ziegler CJ

    更新日期：2006-04-01 00:00:00

  • Superoxide dismutase inhibition of alkaline hemin-mediated O2 activation.

    abstract：:Inhibition of hemin-mediated O2 activation by bovine superoxide dismutase and the copper tetrammine complex has been examined. It is shown that the inhibitory effect of these species is not due to metabolism of O2-., but to a nonspecific inhibition of the process by the Cu2+ ion. We propose that the inhibition occurs ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(89)80026-1

    authors： Adams C,Adams PA

    更新日期：1989-09-01 00:00:00

  • Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.

    abstract：:A series of new heterometallic gold(I) thiolates containing ferrocenyl-phoshines were synthesized. Their antimicrobial properties were studied and compared to that of FDA-approved drug, auranofin (Ridaura), prescribed for the treatment of rheumatoid arthritis. MIC in the order of one digit micromolar were found for mo...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2014.05.008

    authors： Hokai Y,Jurkowicz B,Fernández-Gallardo J,Zakirkhodjaev N,Sanaú M,Muth TR,Contel M

    更新日期：2014-09-01 00:00:00

  • Cleavage of an RNA analog by Zn(II) macrocyclic catalysts appended with a methyl or an acridine group.

    abstract：:Two macrocycles (1 and 2) are prepared that incorporate pendent groups in macrocycle 3 (3=1-oxa-4,7,10-triazacyclododecane) with the goal of studying the effect of these pendent groups on metal ion complexation, solution chemistry and catalysis. Zn(1) contains a macrocyclic ligand with a pendent acridine group and Zn(...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.03.002

    authors： Rossiter CS,Mathews RA,Morrow JR

    更新日期：2007-06-01 00:00:00

  • Cytotoxic activity, X-ray crystal structures and spectroscopic characterization of cobalt(II), copper(II) and zinc(II) coordination compounds with 2-substituted benzimidazoles.

    abstract：:Herein we present the synthesis, structural and spectroscopic characterization of coordination compounds of cobalt(II), copper(II) and zinc(II) with 2-methylbenzimidazole (2mbz), 2-phenylbenzimidazole (2phbz), 2-chlorobenzimidazole (2cbz), 2-benzimidazolecarbamate (2cmbz) and 2-guanidinobenzimidazole (2gbz). Their cyt...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2009.05.018

    authors： Sánchez-Guadarrama O,López-Sandoval H,Sánchez-Bartéz F,Gracia-Mora I,Höpfl H,Barba-Behrens N

    更新日期：2009-09-01 00:00:00

  • Intercalation of tetracationic metalloporphyrins and related compounds into DNA.

    abstract：:Electron paramagnetic resonance (e.p.r.) studies of thin DNA-chelate films indicate that both the water soluble planar macrocyclic chelates, cobalt (II) tetra (2,3-N-methylpyridinium) porphyrazine (cobalt (II) TMTPPA), and vanadyl (II) 5,10,15,20-tetra-(4-methylpyridinium) porphyrin (Vo (II) TMTPyP) can bind to calf t...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(88)85021-9

    authors： Dougherty G

    更新日期：1988-10-01 00:00:00

  • Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells.

    abstract：:Cisplatin is one of the most widely used anticancer drugs. Its side effects, however, have motivated researchers to search for equally effective analogs that are better tolerated. Selectively targeting cancer tissue is one promising strategy. For this purpose, a platinum(IV) complex was conjugated to the cancer-target...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.02.012

    authors： Graf N,Mokhtari TE,Papayannopoulos IA,Lippard SJ

    更新日期：2012-05-01 00:00:00

  • A resonance Raman study of native stellacyanin and its Ni(II) derivative. On the origin of the 450-nm electronic absorption.

    abstract：:The resonance Raman spectra of native stellacyanin and its Ni(II) derivative has been investigated. Raman intensity as a function of the exciting frequency shows minima at about 440--460 nm. Moreover, the resonance Raman spectra of the Ni(II) derivative indicate similar symmetry and nature of ligands, namely, one cyst...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(85)83012-9

    authors： Musci G,Desideri A,Morpurgo L,Tosi L

    更新日期：1985-02-01 00:00:00

  • On coordination modes of adenine in cadmium(II) complexes.

    abstract：:Complexes of cadmium(II) derivatives with adenine from water or by simulation of physiological conditions are obtained. The complexes have been studied by spectroscopic, conductometric, 1H-NMR, and by TG and DSC measurements. Possible coordination modes of the ligand are proposed. ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(87)80023-5

    authors： Fontana A,Maggio F,Pizzino T

    更新日期：1987-02-01 00:00:00

  • One-dimensional chiral copper (II) complexes with novel nano-structures and superior antitumor activity.

    abstract：:Three novel copper(II) compounds of formulas {[Cu(Phen)(Ala)]·NO3·H2O}n (1), {[Cu(Phen)(Ala)]·NO3}n (2) and [Cu(Ala)2]n (3) have been synthesized and determined by X-ray diffraction. 1 and 2 are shown in one dimensional long-chain chiral structures, and 3 is a two dimensional checkerboard-type structure. Both 1 and 2 ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.01.007

    authors： Zhang WC,Tang X,Lu X

    更新日期：2016-03-01 00:00:00

  • The preparation of N-acetyl-Co(III)-microperoxidase-8 (NAcCoMP8) and its ligand substitution reactions: a comparison with aquacobalamin (vitamin B(12a)).

    abstract：:The synthesis of the Co(III) porphyrin octapeptide N-acetyl-Co(III) microperoxidase-8 (NAcCoMP8) is described. NAcCoMP8 provides a means of comparing and contrasting the chemistry of Co(III) porphyrins and corrins to assess the influence of the macrocycle. Log K values, and ΔH and ΔS, for the coordination of anionic (...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2013.03.001

    authors： Mathura S,Sannasy D,de Sousa AS,Perry CB,Navizet I,Marques HM

    更新日期：2013-06-01 00:00:00

  • A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol.

    abstract：:The anticancer drug cisplatin was encapsulated within the cucurbit[7]uril macrocycle to form the host-guest complex: cisplatin@CB[7]. This was then incorporated into gelatin and 0-4% w/v polyvinyl alcohol (PVA)-based hydrogels as slow release drug delivery vehicles. The hydrogels demonstrated predicable swelling and d...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2014.02.004

    authors： Oun R,Plumb JA,Wheate NJ

    更新日期：2014-05-01 00:00:00

  • Nitrate/nitrite reductase activity of sulfido/selenido bridged dinuclear ruthenium(III) complexes.

    abstract：:Series of dinuclear species [Ru(2)(L)(2)(LH)(2)-mu-S(2)Cl(2)], [Ru(2)(L)(2)(LH)(4)-mu-Se(2)Cl(2)] (L=L(1)H and L(3)H) and [Ru(2)(L(2))(2)(L(2)H)-mu-Se(2)Cl(2)].2H(2)O, where L(1)H, L(2)H and L(3)H represent for 2-mercapto-5-phenyl-1,3,4-oxadiazole, 2-mercapto-benzimidazole and 2-mercapto-benzothiazole, respectively, h...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(01)00218-5

    authors： Mishra L,Vilaplana R,Singh VK,Yadaw AK,González-Vilchez F

    更新日期：2001-09-01 00:00:00

  • The synthesis and spectral investigation of a novel highly water-soluble, aggregation-free antimony(V)-phthalocyanine absorbing light in optical therapeutical window.

    abstract：:A novel antimony-phthalocyanine, [Sb(H(3)tsppc)(OH)(2)], where H(3)tsppc denotes monodeprotonated tetrakis{(2',6'-dimethyl-4'-sulfonic acid)phenoxyl}phthalocyaninate, has been synthesized through sulfonation of [Sb(tppc)(OH)(2)](+) (tppc denotes tetrakis{(2',6'-dimethyl)phenoxyl}phthalocyaninate) in concentrated sulfu...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.08.004

    authors： Isago H,Fujita H,Sugimori T

    更新日期：2012-12-01 00:00:00

  • Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes.

    abstract：:The 1,7-diacetate-4,10-diacetamide substituted 1,4,7,10-tetraazacyclododecane structural unit is common to several responsive Magnetic Resonance Imaging (MRI) contrast agents (CAs). While some of these complexes (agents capable of sensing fluctuations in Zn2+, Ca2+ etc. ions) have already been tested in vivo, the deta...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2020.111042

    authors： Tircsó G,Tircsóné Benyó E,Garda Z,Singh J,Trokowski R,Brücher E,Sherry AD,Tóth É,Kovács Z

    更新日期：2020-05-01 00:00:00

  • Inhibition of the GDP/GTP exchange reaction of ras p21 by aluminum ion.

    abstract：:In an effort to understand the biochemical mechanisms of aluminum-induced neurotoxicity, we investigated the effects of aluminum ion, Al3+, on the Mg(2+)- and nucleotide-dependent protein, ras p21. Picomolar Al3+ concentrations inhibited the GTPase activity of ras p21 in an Mg(2+)-dependent manner, consistent with an ...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0162-0134(96)00188-2

    authors： Landino LM,Macdonald TL

    更新日期：1997-05-01 00:00:00

  • Engineering a well-ordered, functional protein-gold nanoparticle assembly.

    abstract：:The study of interactions between proteins and nanoparticles is important to advancing applications of nanoparticles in biology, medicine, and materials science. Here, we report the encapsulation of a 5-nm diameter gold nanoparticle (AuNP) by thermophilic ferritin (tF), achieved in nearly quantitative yield under mild...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2013.10.003

    authors： Cheung-Lau JC,Liu D,Pulsipher KW,Liu W,Dmochowski IJ

    更新日期：2014-01-01 00:00:00

  • Complexation of 5-fluorosalicylic acid with copper(II): a pH-potentiometric, UV-vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra.

    abstract：:The copper(II)-5-fluorosalicylic acid system was investigated in water and 50 v/v% water-methanol mixture by pH potentiometry combined with UV-vis spectrophotometry, and by the two-dimensional ESR simulation method, respectively. The data revealed that the stable paramagnetic mono- and bis(salicylato) copper(II) compl...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.07.019

    authors： Szabó-Plánka T,Gyurcsik B,Nagy NV,Rockenbauer A,Sípos R,Sima J,Melník M

    更新日期：2008-01-01 00:00:00

  • Synthesis, characterization, and binding affinity of hydrosulfide complexes of synthetic iron(II) porphyrinates.

    abstract：:The binding and reactivity of the hydrosulfide ion (HS-) to iron(II) porphyrinates has been examined for several synthetic meso-tetraphenylporphine (TPP) derivatives. In all cases, HS- coordinates to the iron centers in a 1:1 stoichiometry with formation constants (Kf) that reflect the electronic characteristics of th...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2016.08.014

    authors： Meininger DJ,Arman HD,Tonzetich ZJ

    更新日期：2017-02-01 00:00:00

  • Biophysical insights into the interaction of Ru(II) polypyridyl complexes with the RNA triplex poly(U)•poly(A)*poly(U). Intercalative ligand shape effect on third-strand stabilization.

    abstract：:To explore the correlating thermodynamic factors to the structural aspects that account for the stability of the RNA triplex, two functional Ru(II) complexes containing the same ancillary ligands and different intercalative ligands, [Ru(bpy)(2)(mip)](2+) (bpy=2,2'-bipyridine, mip=2'-(3",4"-methylene-dioxyphenyl)imidaz...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2012.11.009

    authors： Tan L,Xie L,Sun X,Zeng L,Yang G

    更新日期：2013-03-01 00:00:00

  • Involvement of organic molybdenum compounds in the interaction between copper, molybdenum, and sulfur.

    abstract：:The effect on Cu metabolism of two organic Mo compounds, cysteine-Mo (CM) and cysteine-Mo-S (CMS), and of an inorganic compound, tetrathiomolybdate (TTM), was investigated in sheep. Intravenous administration of CMS or TTM increased total plasma Cu concentrations and promoted the appearance of trichloroacetic acid (TC...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(86)80011-3

    authors： Allen JD,Gawthorne JM

    更新日期：1986-06-01 00:00:00

  • Synthesis, properties, and antitumor effects of a new mixed phosphine gold(I) compound in human colon cancer cells.

    abstract：:The antineoplastic potential of a new stable mixed phosphine gold(I) complex containing tris(tert-butyl)phosphine (tBu3P) and bis(diphenylphosphino)ethene (dppet), namely [Au(tBu3P)(dppet)Cl], has been investigated in the human colon cancer HCT-116 cell line. The (31)P NMR solution study, confirms the structural featu...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2013.03.014

    authors： Lupidi G,Avenali L,Bramucci M,Quassinti L,Pettinari R,Khalife HK,Gali-Muhtasib H,Marchetti F,Pettinari C

    更新日期：2013-07-01 00:00:00

  • Metal ligand substitution and evidence for quinone formation in taurine/alpha-ketoglutarate dioxygenase.

    abstract：:The three metal-binding ligands of the archetype Fe(II)/alpha-ketoglutarate (alphaKG)-dependent hydroxylase, taurine/alphaKG dioxygenase (TauD), were systematically mutated to examine the effects of various ligand substitutions on enzyme activity and metallocenter properties. His99, coplanar with alphaKG and Fe(II), i...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2007.01.011

    authors： Grzyska PK,Müller TA,Campbell MG,Hausinger RP

    更新日期：2007-05-01 00:00:00

  • Kinetics and equilibria for the formation of a new DNA metal-intercalator: the cyclic polyamine Neotrien/copper(II) complex.

    abstract：:A study has been performed of the kinetics and equilibria involved in complex formation between the macrocyclic polyamine 2,5,8,11-tetraaza[12]-[12](2,9)[1,10]-phenanthrolinophane (Neotrien) and Cu(II) in acidic aqueous solution and ionic strength 0.5 M (NaCl), by means of the stopped-flow method and UV spectrophotome...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2003.08.010

    authors： Biver T,Secco F,Tinè MR,Venturini M

    更新日期：2004-01-01 00:00:00

  • The influence of the Cys46/Cys55 disulfide bond on the redox and spectroscopic properties of human neuroglobin.

    abstract：:Neuroglobin is a monomeric globin containing a six-coordinate heme b, expressed in the nervous system, which exerts an important neuroprotective role. In the human protein (hNgb), Cys46 and Cys55 form an intramolecular disulfide bond under oxidizing conditions, whose cleavage induces a helix-to-strand rearrangement of...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2017.10.005

    authors： Bellei M,Bortolotti CA,Di Rocco G,Borsari M,Lancellotti L,Ranieri A,Sola M,Battistuzzi G

    更新日期：2018-01-01 00:00:00

  • Stimulation of cyclic AMP production in chick renal tissue by cadmium and manganese.

    abstract：:The effects of cadmium on production of cyclic AMP by partially purified chick renal plasma membrane preparations and binding of 125I-parathyrin to the membranes have been investigated. At certain concentrations Cd2+ ions (and Mn2+ ions) markedly stimulated the production of cyclic AMP by the tissue. It was found that...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/0162-0134(85)85005-4

    authors： Cook DB,Dewar JH,Ershadi SS

    更新日期：1985-07-01 00:00:00

  • Platinum(II) and palladium(II) complexes with (N,N') and (C,N,N')- ligands derived from pyrazole as anticancer and antimalarial agents: synthesis, characterization and in vitro activities.

    abstract：:The study of the reactivity of three 1-(2-dimethylaminoethyl)-1H-pyrazole derivatives of general formula [1-(CH(2))(2)NMe(2)}-3,5-R(2)-pzol] {where pzol represents pyrazole and R=H (1a), Me (1b) or Ph (1c)} with [MCl(2)(DMSO)(2)] (M=Pt or Pd) under different experimental conditions allowed us to isolate and characteri...

    journal_title：Journal of inorganic biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.jinorgbio.2011.09.021

    authors： Quirante J,Ruiz D,Gonzalez A,López C,Cascante M,Cortés R,Messeguer R,Calvis C,Baldomà L,Pascual A,Guérardel Y,Pradines B,Font-Bardía M,Calvet T,Biot C

    更新日期：2011-12-01 00:00:00