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The metal complexes of N-confused porphyrin as heme model compounds.

Abstract：

:Recently, metal complexes of the isomers and analogs of porphyrin have become important model compounds for heme enzymes and proteins. While the chemistry of metalloporphyrins as heme models still attracts attention, the isomers and analogs of porphyrins provide insight into the biological choice of porphine as the macrocycle of choice and also help model reactive intermediates, such as high valent oxidation states. In this mini-review, we discuss the heme-relevant chemistry of N-confused porphyrin, an isomer of porphyrin with an inverted pyrrole ring, and focus on the chemistry of manganese, iron, and cobalt. The metallation chemistry of this macrocycle is more diverse than normal porphyrin, and involves tautomerization, C-H bond activation, the Lewis basicity of the external nitrogen, and issues with nucleophilic sensitivity. Despite the challenges posed by N-confused porphyrin, significant progress has been made toward generating heme-model complexes with this macrocycle.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Harvey JD,Ziegler CJ

doi

10.1016/j.jinorgbio.2006.01.016

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

869-80

issue

4

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(06)00018-3

journal_volume

100

pub_type

杂志文章,评审

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