当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > Copper(II) diclofenac complexes: Synthesis, structural studies and interaction with albumins and calf-thymus DNA.

Copper(II) diclofenac complexes: Synthesis, structural studies and interaction with albumins and calf-thymus DNA.

Abstract：

:The reaction of the copper(II) diclofenac complex [Cu(dicl)2(H2O)2] (1) (dicl = deprotonated diclofenac (Hdicl)) with the chelating N-donor ligands ethylenediamine (en), propan-1,3-diamine (pn), unsymmetrical dimethylethylene-diamine (unsym-dmen) and N,N,N',N'-tetramethylethylene-diamine (temed) in methanol-water (4:1 v/v) yielded the novel copper(II) complexes [Cu(en)2(H2O)2](dicl)2·2H2O (2), [Cu(pn)2(H2O)2](dicl)2·2H2O (3), [Cu(unsym-dmen)2(H2O)](dicl)2·H2O (4) and [Cu(temed)(dicl)2] (5), respectively. All the synthesized complexes were characterized by spectroscopic (UV-vis, FT-IR) methods. The structures of complexes 2, 3 and 5 were unambiguously determined by single-crystal X-ray crystallography. X-ray structures of complexes clearly revealed the ionic structure of complexes 2, 3 and the covalent structure of complex 5. The geometry of complex 4 was optimized by Density Functional Theory (DFT) calculations. The ability of the complexes 1-5 to bind to calf-thymus DNA was monitored in vitro by diverse techniques (UV-vis spectroscopy, cyclic voltammetry, viscosity measurements) and via competitive studies with ethidium bromide. The interaction of complexes 1-5 with bovine serum albumin was studied in vitro by fluorescence emission spectroscopy and the corresponding binding constants were calculated. The biological behavior of complexes 1-5 was compared with previously reported Cu(II), Mn(II) and Ni(II) complexes of diclofenac.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Kumar S,Sharma RP,Venugopalan P,Ferretti V,Perontsis S,Psomas G

doi

10.1016/j.jinorgbio.2018.07.009

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

97-108

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(18)30091-6

journal_volume

187

pub_type

杂志文章

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