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Metal-based antibody drug conjugates. Potential and challenges in their application as targeted therapies in cancer.

Abstract：

:Antibody drug conjugates have emerged as a very attractive type of targeted therapy in cancer. They combine the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutics. This review focuses on antibody drug conjugates based on metal-containing cytotoxic payloads. We will also describe antibody drug conjugates (ADCs) in which a metal-based component (mostly metallic nanoparticles) exerts a relevant function in the ADC (for photodynamic or photothermal therapy, as air-plasma-enhancer or chemo-sensitizer, as carrier of other cytotoxic payloads or as an integral part of the linker structure). Challenges and opportunities to increase the translational potential of these ADCs will be discussed.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Del Solar V,Contel M

doi

10.1016/j.jinorgbio.2019.110780

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

110780

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(19)30165-5

journal_volume

199

pub_type

杂志文章,评审

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