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A Schiff base complex of chromium(III): an efficient inhibitor for the pathogenic and invasive potential of Shigella dysenteriae.

Abstract：

:A Schiff base complex of chromium(III), transdiaqua[N,N'ethylenebis (salicylideneimine)chromium(III)]perchlorate, [Cr(salen)(OH(2))(2)](+), was found to have an inhibitory effect on the growth of Shigella dysenteriae. The chromium(III) complex was found to cure (remove) the invasive plasmid and thereby render the microbe more sensitive to the tested antibiotics. The loss in the catalytic activity of the isolated endo-alpha-N-acetyl galactosaminidase on mucin as a substrate was also observed in the presence of [Cr(salen)(OH(2))(2)](+). This suggests that [Cr(salen)(OH(2))(2)](+) is toxic to the microbe and could make the microbe non-pathogenic and non-invasive, thus establishing its role in microbiological applications to reduce the toxic potentials of a microbe.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Shrivastava HY,Devaraj SN,Nair BU

doi

10.1016/j.jinorgbio.2003.11.012

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

387-92

issue

2

eissn

0162-0134

issn

1873-3344

pii

S0162013403004550

journal_volume

98

pub_type

杂志文章

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