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Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes.

Abstract：

:The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 microM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized=200 microM).

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Golfeto CC,Von Poelhsitz G,Selistre-de-Araújo HS,de Araujo MP,Ellena J,Castellano EE,Lopes LG,Moreira IS,Batista AA

doi

10.1016/j.jinorgbio.2009.12.015

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

489-95

issue

5

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(09)00320-1

journal_volume

104

pub_type

杂志文章

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