Abstract:
:The study of possible relationships between iron and vanadium metabolism (E. Sabbioni and E. Marafante, Proc. XIth Int. Conf. Biochem., 13-5-R122, Toronto, Canada) was extended to the vanadium in the biochemical mechanisms which involve the exchange of iron between transferrin and ferritin. The transfer of vanadium between transferrin and ferritin was investigated using 48V radiotracer and gel filtration technique. 48V labeled human transferrin and horse spleen ferritin, 48V plasma from rats injected with 48VO2+, unlabelled rat liver cytosol, and plasma were used as sources of the two proteins for their incubation under different conditions. The results show that the equilibrium: V - transferrin in equilibrium V - ferritin occurs in vitro at physiological pH under the conditions of this experiment. No transfer of vanadium between the two proteins, however, occurs when they are incubated simply in a buffer at pH = 7.4. The maximum transfer was observed when transferrin and ferritin were mixed in their natural environments such as plasma and liver cytosol. This suggests that the exchange of the vanadium between the two proteins is affected by biochemical factors which are present in the body. A brief evaluation of the significance on the very low amounts of the element exchanged between the two proteins is also presented.
journal_name
J Inorg Biochemjournal_title
Journal of inorganic biochemistryauthors
Sabbioni E,Rade J,Bertolero Fdoi
10.1016/s0162-0134(00)80271-8subject
Has Abstractpub_date
1980-07-01 00:00:00pages
307-15issue
4eissn
0162-0134issn
1873-3344pii
S0162-0134(00)80271-8journal_volume
12pub_type
杂志文章abstract::Aqueous solutions of the four highest vanadium oxidation states exhibit four diverse colors, which only hint at the diverse reactions that these ions can undergo. Cationic vanadium ions form complexes with ligands; anionic vanadium ions form complexes with ligands and self-react to form isopolyanions. All vanadium spe...
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