当前位置： SCI文献检索 > JOURNAL OF INORGANIC BIOCHEMISTRY期刊下所有文献 > The role of heme propionate in controlling the redox potential of heme: square wave voltammetry of protoporphyrinato IX iron (III) in aqueous surfactant micelles.

The role of heme propionate in controlling the redox potential of heme: square wave voltammetry of protoporphyrinato IX iron (III) in aqueous surfactant micelles.

Abstract：

:The proton equilibrium in aqueous surfactant solutions of hemin, (PPIX)Fe(H2O)+2, involving the propionic acid groups is reported (PPIX = protoporphyrinato IX). The surfactant used are sodium dodecyl sulphate (SDS), triton X-100 (TX-100) and hexadecyl trimethylammonium bromide (CTAB). The pKa values, determined spectroscopically from the pH variations of the Soret absorption, are found at ca. 3.5 in SDS and TX-100 micelles. In the cationic surfactant (CTAB) the absorbance of hemin is independent of the hydrogen ion concentration in solution and this surfactant form a salt-link with the heme propionate group. The dependence of mid-point potential on pH indicates that the heme propionate undergoes a redox-linked changed in pKa from 3.2-3.5 in the ferric form to 4.4-4.5 in the ferrous form (27 degrees C, mu = 0.2 M). The change in the mid-point potential per unit change in pH. delta E/delta pH, is ca. -59 mV. Replacement of the water molecules in hemin by tetrahydrofuran, (PPIX)Fe(thf)+2, induces a considerable shift of pKa of the heme propionate: 6.2-6.8 in the ferric form and 7.5-7.8 in the ferrous form. The lower value of pKa in diaquo hemin is attributed to stabilisation of the propionate by a hydrogen bond with coordinated water molecules. All these results may be interpreted in terms of the involvement of a heme propionate group in redox linked uptake of protons and the influence of hydrogen bonding and salt-link formation on the pKa of the proton equilibrium.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Das DK,Medhi OK

doi

10.1016/s0162-0134(98)10002-8

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

83-90

issue

2

eissn

0162-0134

issn

1873-3344

pii

S0162-0134(98)10002-8

journal_volume

70

pub_type

杂志文章

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