Crystal structure based design of functional metal/protein hybrids.

abstract：:Changes in speciation of copper(II) in reactions with epigallocatechin gallate (EGCG) and gallic acid (GA) as a function of pH have been investigated by multifrequency (X- and S-band) EPR spectroscopy in the fluid and frozen states. The EPR spectra show the formation of three distinct mononuclear species with each of ...

journal_title：Journal of inorganic biochemistry

authors： Pirker KF,Baratto MC,Basosi R,Goodman BA

更新日期：2012-07-01 00:00:00

abstract：:The impact of Zn(2+) ion on interactions of flavonols galangin (Gal), kaempferol (Kae), quercetin (Que) and myricetin (Myr) with bovine serum albumin (BSA) in aqueous solution were studied by fluorescence quenching technique. The results exhibited that Zn(2+) ion affected significantly the interactions and the effect ...

journal_title：Journal of inorganic biochemistry

authors： Cao S,Jiang X,Chen J

更新日期：2010-02-01 00:00:00

abstract：:The putative platinum(IV) anticancer drugs, [Pt{((R)NCH(2))(2)}(py)(2)XY] (X,Y=Cl, R=p-HC(6)F(4) (1a), C(6)F(5) (1b); X,Y=OH, R=p-HC(6)F(4) (2); X=Cl, Y=OH, R=p-HC(6)F(4) (3), py = pyridine) have been prepared by oxidation of the Pt(II) anticancer drugs [Pt{((R)NCH(2))(2)}(py)(2)] (R=p-HC(6)F(4) (4a) or C(6)F(5) (4b))...

journal_title：Journal of inorganic biochemistry

authors： Guo SX,Mason DN,Turland SA,Lawrenz ET,Kelly LC,Fallon GD,Gatehouse BM,Bond AM,Deacon GB,Battle AR,Hambley TW,Rainone S,Webster LK,Cullinane C

更新日期：2012-10-01 00:00:00

abstract：:Preparations of cis- and trans-platinum(II) complexes of diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe) have been described. These complexes were identified and characterized by far-IR, 1H NMR, 13C NMR, 31P NMR and 195Pt NMR and microanalyses. The crystal and molecular structure of trans-platinum(II) complex i.e., tr...

journal_title：Journal of inorganic biochemistry

authors： Kalinowska U,Matławska K,Checińska L,Domagała M,Kontek R,Osiecka R,Ochocki J

更新日期：2005-10-01 00:00:00

abstract：:The effects exerted by the new complex cis-dichloro-1,2-propylenediaminetetraacetato ruthenium (III), H[RuCl(2)(PDTA-H(2))] [1, RAP], on DNA and cultured tumor cells (ovarian carcinoma TG cell line) were studied. The comparative study of circular dichroism (CD) spectra obtained from DNA and RAP-DNA system evidences th...

journal_title：Journal of inorganic biochemistry

authors： Vilaplana RA,Delmani F,Manteca C,Torreblanca J,Moreno J,García-Herdugo G,González-Vílchez F

更新日期：2006-11-01 00:00:00

abstract：:The reaction between reduced Pseudomonas cytochrome c551 and cytochrome oxidase with two inorganic metal complexes, Co(phen)3(3+) and Mn(CyDTA)(H2O)-, has been followed by stopped-flow spectrophotometry. The electron transfer to cytochrome c551 by both reactants is a simple process, characterized by the following seco...

journal_title：Journal of inorganic biochemistry

authors： Tordi MG,Silvestrini MC,Adzamli K,Brunori M

更新日期：1987-07-01 00:00:00

abstract：:Three new copper(II) complexes of stoichiometry [Cu(L-dipeptide)].nH(2)O, containing as ligands the dipeptides L-alanine-L-isoleucine, L-alanine-L-threonine and L-alanine-L-tyrosine were prepared. They were characterized by single crystal X-ray diffractometry, and electronic and infrared spectroscopy. In all cases, th...

journal_title：Journal of inorganic biochemistry

authors： Facchin G,Torre MH,Kremer E,Piro OE,Castellano EE,Baran EJ

更新日期：2002-04-28 00:00:00

abstract：:The antiproliferative properties of a series of structurally-related gold(I) and silver(I) linear complexes inspired to the clinically established gold-based drug auranofin were investigated in A2780 ovarian cancer cells and in their auranofin (A2780/AF-R) and cisplatin (A2780/CDDP-R) resistant counterparts. In A2780 ...

journal_title：Journal of inorganic biochemistry

authors： Landini I,Massai L,Cirri D,Gamberi T,Paoli P,Messori L,Mini E,Nobili S

更新日期：2020-07-01 00:00:00

abstract：:Copper(II) and zinc(II) complexes of the peptides Ac-HisValHis-NH2 and Ac-HisValGlyAsp-NH2 related to the active site of the enzyme CuZnSOD were studied by potentiometric and spectroscopic (UV-Vis, CD and EPR) techniques. The results reveal that both ligands have effective metal binding sites, but the tripeptide is a ...

journal_title：Journal of inorganic biochemistry

authors： Bóka B,Myari A,Sóvágó I,Hadjiliadis N

更新日期：2004-01-01 00:00:00

abstract：:Maintenance of cellular iron homeostasis demands the coordination of iron uptake, intracellular storage, and utilization. Recent investigations suggest that a single genetic regulatory system orchestrates the expression of proteins with central importance for all three aspects of cellular iron metabolism at the level ...

journal_title：Journal of inorganic biochemistry

authors： Kühn LC,Hentze MW

更新日期：1992-08-15 00:00:00

abstract：:Imidazole glycerol phosphate dehydratase (IGPD) catalyses the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, an important late step in the biosynthesis of histidine. IGPD, isolated as a low molecular weight and inactive apo-form, assembles with specific divalent metal cations to form a cata...

journal_title：Journal of inorganic biochemistry

authors： Petersen J,Hawkes TR,Lowe DJ

更新日期：2000-05-30 00:00:00

abstract：:Nitroxyl (HNO) has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke positive inotropic effects in canine cardiac muscle. The release of nitrite during decomposition limits the use of AS requiring other HNO sources. Acyloxy nitroso c...

journal_title：Journal of inorganic biochemistry

authors： DuMond JF,Wright MW,King SB

更新日期：2013-01-01 00:00:00

abstract：:Aurothiomalate (AuTm) is an old, clinically established, antiarthritic gold drug that is currently being reconsidered as a candidate drug for cancer treatment and for other therapeutic indications within a more general drug repositioning program. As the biological effects of gold drugs seem to be mediated, mainly, by ...

journal_title：Journal of inorganic biochemistry

authors： Darabi F,Marzo T,Massai L,Scaletti F,Michelucci E,Messori L

更新日期：2015-08-01 00:00:00

abstract：:The interaction of heme or heme-artemisinin adducts (heme-art) with different peptides mimicking repeat sequences of the Histidine-Rich-Protein-II of Plasmodium falciparum (PfHRP-II) was investigated. The pseudo-first order rate constants of the coordination of heme or heme-art onto a histidine rich peptide, used as a...

journal_title：Journal of inorganic biochemistry

authors： Accardo A,Laurent SA,Mazarguil H,Meyer M,Robert A,Meunier B

更新日期：2007-11-01 00:00:00

abstract：:Computational studies were conducted to identify the favourable formation of the inclusion complex of chloramphenicol with cyclodextrins. The results of molecular docking and molecular dynamics predicted the strongest interaction of chloramphenicol with γ-cyclodextrin. Further, the inclusion complex of chloramphenicol...

journal_title：Journal of inorganic biochemistry

authors： Gannimani R,Ramesh M,Mtambo S,Pillay K,Soliman ME,Govender P

更新日期：2016-04-01 00:00:00

abstract：:In the quest for more effective pain palliation radiopharmaceuticals for metastatic bone cancer, this paper relates results obtained with 166Ho complexed to the bone-seeking bisphosphonate, 1-hydroxy-4-aminopropililydenediphosphonate (APD). APD is itself a bone cancer pain palliation agent and this work was therefore ...

journal_title：Journal of inorganic biochemistry

authors： Zeevaart JR,Jarvis NV,Louw WK,Jackson GE,Cukrowski I,Mouton CJ

更新日期：1999-04-01 00:00:00

abstract：:The effect of the Cu(II)-mitoxantrone complex on the DNA synthesis of HL-60 human leukemia cells has been studied by the technique of isotopic liquid scintillation. The results indicated that the complex shows a stronger ability to inhibit DNA synthesis of the tumor cells, and thus it may become a better antitumor dru...

journal_title：Journal of inorganic biochemistry

authors： Yang P,Wang H,Gao F,Yang B

更新日期：1996-05-01 00:00:00

abstract：:Copper(II) complexes of the peptide fragment (Dpl122-130) encompassing the sequence 122-130 of human doppel protein were characterized by potentiometric, UV-Visible, CD and EPR spectroscopic methods. An analogous peptide, in which the aspartate residue was substituted by an asparagine amino acid, was synthesized in or...

journal_title：Journal of inorganic biochemistry

authors： Mendola DL,Magrì A,Hansson O,Bonomo RP,Rizzarelli E

更新日期：2009-05-01 00:00:00

abstract：:We have analyzed the early stages of unfolding of cytochromes c-b562 (PDB ID: 2BC5) and Rd apo b562 (PDB ID: 1YYJ). Our geometrical approach proceeds from an analysis of the crystal structure reported for each protein. We quantify, residue-by-residue and region-by-region, the spatial and angular changes in the structu...

journal_title：Journal of inorganic biochemistry

authors： Kozak JJ,Gray HB,Garza-López RA

更新日期：2020-10-01 00:00:00

abstract：:Copper(II) and nickel(II) complexes of the terminally protected nonapeptide Ac-SGAEGHHQK-NH2 modeling the metal binding sites of the (8-16) domain of amyloid-β have been studied by potentiometric, UV-vis, CD and ESR spectroscopic methods. The studies on the mutants containing only one of the histidyl residues (Ac-SGAE...

journal_title：Journal of inorganic biochemistry

authors： Grenács Á,Sanna D,Sóvágó I

更新日期：2015-10-01 00:00:00

abstract：:Nanosized polyphosphazene-platinum (II) conjugates with a wide range of molecular weight from 24,000 to 115,000 were synthesized to study their tumor selectivity by enhanced permeability and retention (EPR) effect and their antitumor activity. It has been found from biodistribution study that the present polyphosphaze...

journal_title：Journal of inorganic biochemistry

authors： Jun YJ,Kim JI,Jun MJ,Sohn YS

更新日期：2005-08-01 00:00:00

abstract：:The study of modified synthetic procedure of water soluble morin-5'-sulfonic acid sodium salt (NaMSA) involving less aggressive chemicals and carried out at mild conditions was described. The NaMSA salt is a convenient source of anionic morin-5'-sulfonic ligand (MSA) in ion exchange reactions. The coordination ability...

journal_title：Journal of inorganic biochemistry

authors： Pieniążek E,Kalembkiewicz J,Dranka M,Woźnicka E

更新日期：2014-12-01 00:00:00

abstract：:Glutaredoxins (Grxs) are ubiquitous thioltransferases and members of the thioredoxin (Trx) fold superfamily. They have multiple functions in cells including oxidative stress responses and cell signaling. A novel glutaredoxin from buckwheat (rbGrx) with higher catalytic activity was identified, cloned, and purified. Th...

journal_title：Journal of inorganic biochemistry

authors： Zhang X,Wang W,Li C,Zhao Y,Yuan H,Tan X,Wu L,Wang Z,Wang H

更新日期：2017-08-01 00:00:00

abstract：:An examination was made of the effects of tetrathiomolybdate (TTM), ammonium molybdate (AM), sodium sulphide, and two molybdo amino acids (cysteine-Mo, cysteine-Mo-S) on the distribution of Cu and Zn among proteins in extracts of the livers and kidneys of rats and sheep. Tetrathiomolybdate caused a shift in the chroma...

journal_title：Journal of inorganic biochemistry

authors： Allen JD,Gawthorne JM

更新日期：1987-11-01 00:00:00

abstract：:Nickel-containing carbon monoxide dehydrogenases, acetyl-CoA synthases, nickel-iron hydrogenases, and diron hydrogenases are distinct metalloenzymes yet they share a number of important characteristics. All are O(2)-sensitive, with active-sites composed of iron and/or nickel ions coordinated primarily by sulfur ligand...

journal_title：Journal of inorganic biochemistry

authors： Lindahl PA

更新日期：2012-01-01 00:00:00

abstract：:Aiming to investigate the use of tridentate ligands to develop new bireductively activated prodrugs, two N(2)O-donor ligands (HL1: [(2-hydroxybenzyl)(2-(imidazol-2-yl)ethyl)]amine; and HL2: [(2-hydroxybenzyl)(2-(pyridil-2-yl)ethyl]amine) were used to synthesize new Co(III) complexes, 1 and 2. Both complexes were chara...

journal_title：Journal of inorganic biochemistry

authors： Souza ET,Castro LC,Castro FA,do Canto Visentin L,Pinheiro CB,Pereira MD,de Paula Machado S,Scarpellini M

更新日期：2009-10-01 00:00:00

abstract：:A heterodinuclear (Ru(II), Co(III)) metal polypyridyl complex [(phen)(2)Ru(bpibH(2))Co(phen)(2)](5+) {phen = 1,10-phenanthroline, bpibH(2) = 1,4-bis([1,10]phebanthroline-[5,6-d]imidazol-2-yl)-benzene} has been designed and synthesized. The comparative study on the interactions of the Ru(II)-Co(III) complex with calf t...

journal_title：Journal of inorganic biochemistry

authors： Liang X,Zou X,Tan L,Zhu W

更新日期：2010-12-01 00:00:00

abstract：:EPR-based potentiometric titrations are a well-established method for determining the reduction potentials of cofactors in large and complex proteins with at least one EPR-active state. However, such titrations require large amounts of protein. Here, we report a new method that requires an order of magnitude less prot...

journal_title：Journal of inorganic biochemistry

authors： Wright JJ,Salvadori E,Bridges HR,Hirst J,Roessler MM

更新日期：2016-09-01 00:00:00

abstract：:Oxyhemoglobin is oxidized to methemoglobin by copper(II) in a two-stage reaction that results in conversion of Fe(II) to Fe(III) in heme of the beta subunits, but not the alpha subunits. Glutathione and other thiols, which are slowly oxidized by Cu(II), protect oxyhemoglobin from Cu(II)-induced oxidation. In the prese...

journal_title：Journal of inorganic biochemistry

authors： Smith RC,Reed VD,Webb TR

更新日期：1993-11-15 00:00:00

abstract：:The synthesis and characterization of four palladium(II) complexes with substituted salicylaldehydes (X-saloH) having the general formula [Pd(X-salo)2] was undertaken. The complexes are formulated as [Pd(3-OCH3-salo)2] 1, [Pd(5-NO2-salo)2] 2, [Pd(5-Cl-salo)2] 3, and [Pd(5-Br-salo)2] 4. The structure of complex 1 was v...

journal_title：Journal of inorganic biochemistry

authors： Zianna A,Geromichalos GD,Hatzidimitriou AG,Coutouli-Argyropoulou E,Lalia-Kantouri M,Psomas G

更新日期：2019-05-01 00:00:00