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Effects of Cr(VI) long-term and low-dose action on mammalian antioxidant enzymes (an in vitro study).

Abstract：

:In order to investigate the low-dose long-term Cr(VI) action on antioxidant enzymes in cultured mammalian cells we estimated the activity of glutathione dependent antioxidant enzymes, catalase and superoxide dismutase (SOD) under various chromium concentrations in human epithelial-like L-41 cells. The long-term action of 20 microM causes the toxicity that results in losing of the cell viability by activating the apoptotic process, as identified by morphological analysis, the activation of caspase-3, and DNA fragmentation. The toxic chromium concentration totally destroys glutathione antioxidant system, and diminishes the activity of catalase and cytosolic Cu, ZnSOD. The non-toxic concentration (2 microM) causes the activation of the antioxidant defense systems, and they neutralize the oxidative impact.

journal_name

J Inorg Biochem

journal_title

Journal of inorganic biochemistry

authors

Asatiani N,Sapojnikova N,Abuladze M,Kartvelishvili T,Kulikova N,Kiziria E,Namchevadze E,Holman HY

doi

10.1016/j.jinorgbio.2003.12.014

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

490-6

issue

3

eissn

0162-0134

issn

1873-3344

pii

S0162013403004744

journal_volume

98

pub_type

杂志文章

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