解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2021.5169
更新日期:2021-01-11 00:00:00
abstract::Cholangiocarcinoma is the most common biliary duct malignancy and the second most common primary liver cancer, accounting for 10‑20% of hepatic malignancies. With high mortality and poor prognosis, the 5‑year survival rate of cholangiocarcinoma is only 10%. A previous study demonstrated a significant association betwe...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5165
更新日期:2020-12-30 00:00:00
abstract::Chronic myeloid leukemia (CML) is a malignant hematopoietic disorder distinguished by the presence of a BCR‑ABL1 fused oncogene with constitutive kinase activity. Targeted CML therapy by specific tyrosine kinase inhibitors (TKIs) leads to a marked improvement in the survival of the patients and their quality of life. ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5163
更新日期:2020-12-23 00:00:00
abstract::Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5140
更新日期:2020-12-01 00:00:00
abstract::Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5139
更新日期:2020-12-01 00:00:00
abstract::ETS variant 1 (ETV1) is an oncogenic transcription factor. However, its role in colorectal cancer has remained understudied. The present study demonstrated that ETV1 downregulation led to reduced HCT116 colorectal cancer cell growth and clonogenic activity. Furthermore, the ETV1 mRNA levels were enhanced in colorectal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5133
更新日期:2020-12-01 00:00:00
abstract::Long noncoding RNA (lncRNA) MAF BZIP transcription factor G antisense RNA 1 (MAFG‑AS1) has been demonstrated to serve an important role in the progression of various types of cancer, whereas its role in breast cancer has not been fully elucidated. The present study aimed to explore the potential role and underlying me...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5150
更新日期:2020-11-20 00:00:00
abstract::KRAS‑mutant colorectal cancer (CRC) is a highly malignant cancer with a poor prognosis, however specific therapies targeting KRAS mutations do not yet exist. Anti‑epidermal growth factor receptor (EGFR) agents, including cetuximab and panitumumab, are effective for the treatment of certain patients with CRC. However, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5117
更新日期:2020-11-01 00:00:00
abstract::The impacts of post‑operative abdominal infectious complications increase hematogenous distant metastasis and result in poor long‑term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5102
更新日期:2020-10-01 00:00:00
abstract::Cancer represents a severe challenge to healthcare systems and individuals worldwide. The development of multiple drug resistance is a major issue regarding cancer therapy, which can result in the progression of disease. Cholesterol is a major constituent of cell membranes and participates in the regulation of several...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5124
更新日期:2020-09-22 00:00:00
abstract::The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of our knowledge, there are only...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5098
更新日期:2020-09-01 00:00:00
abstract::Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‑TKI), is widely applied as a first‑line treatment for non‑small cell lung cancer (NSCLC) and greatly improves the clinical outcomes of patients. However, acquired resistance to EGFR‑TKIs remains a major clinical challenge. Here, we identifi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5086
更新日期:2020-09-01 00:00:00
abstract::Accumulating evidence has demonstrated the crucial roles of long non‑coding RNAs (lncRNAs) in various human cancers, including non‑small cell lung cancer (NSCLC). However, to the best of our knowledge, the role of the lncRNA cancer susceptibility candidate 7 (CASC7) in NSCLC has not been clearly determined. The aim of...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5076
更新日期:2020-08-01 00:00:00
abstract::Family with sequence similarity 83 member A (FAM83A) has been recently observed to be upregulated in various types of cancer and hypothesized to be serve as an oncogene. The present study aimed to determine the functional roles and the underlying molecular mechanism of FAM83A in cervical cancer. The results demonstrat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5078
更新日期:2020-08-01 00:00:00
abstract::MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5072
更新日期:2020-08-01 00:00:00
abstract::Combination therapy is a promising and prevalent strategy for osteosarcoma treatment. Curcumin (CUR), as a chemosensitizer, improves the antitumor effect of first‑line chemotherapy drugs. However, due to its poor solubility and instability in physiological conditions, the bioavailability of CUR is limited. In order to...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5067
更新日期:2020-08-01 00:00:00
abstract::In contrast to normal cells, cancer cells typically undergo metabolic reprogramming. Studies have shown that oncogenes play an important role in this metabolic reprogramming. CD38 is a multifunctional transmembrane protein that is expressed abnormally in a variety of tumor types. To investigate the effect and possible...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5040
更新日期:2020-07-01 00:00:00
abstract::SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta‑analysis based on multiple...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5048
更新日期:2020-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most malignant types of cancer, and is associated with high recurrence rates and a poor response to chemotherapy. Immune signatures in the microenvironment of HCC have not been well explored systematically. The aim of the present study was to identify prognostic immune sign...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4998
更新日期:2020-05-01 00:00:00
abstract::Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4973
更新日期:2020-04-01 00:00:00
abstract::Sterile alpha motif and histidine/aspartic acid domain‑containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools. Furthermore, SAMHD1 has been reported to be involved in the pathological p...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4988
更新日期:2020-04-01 00:00:00
abstract::Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4957
更新日期:2020-03-01 00:00:00
abstract::Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases re...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4964
更新日期:2020-03-01 00:00:00
abstract::Tumor necrosis factor‑associated apoptosis‑inducing ligand (TRAIL) is considered to be a potential therapeutic target for various types of cancer. However, colon cancer is difficult to treat due to its resistance to TRAIL. Therefore, various trials have been conducted to overcome TRAIL resistance in colon cancer. The ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4970
更新日期:2020-03-01 00:00:00
abstract::Wilms' tumor is one of the most common malignant tumors of the abdomen in children. However, there is currently no recognized specific biomarker for the clinical diagnosis and prognosis of this tumor. Lipid metabolism is involved in membrane synthesis and oxidation in tumor cells. This process plays an important role ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4948
更新日期:2020-02-01 00:00:00
abstract::Liver cancer is the fourth leading cause of cancer‑related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2 (PIM2), has been shown to be overexpressed in liver cancer, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4936
更新日期:2020-02-01 00:00:00
abstract::Lung cancer is one of the most common types of cancer worldwide. Understanding the molecular mechanisms underlying the development and progression of lung cancer may improve early diagnosis, treatment and prognosis. The aim of the present study was to examine the pathogenesis of lung cancer and to identify potentially...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4926
更新日期:2020-01-01 00:00:00
abstract::Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4918
更新日期:2020-01-01 00:00:00
abstract::Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4916
更新日期:2020-01-01 00:00:00
abstract::Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non‑synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4915
更新日期:2020-01-01 00:00:00
abstract::Hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC) is a global health problem that accounts for more than half of total liver cancer cases in developing countries. Despite the growing number of researches conducted, the molecular mechanism underlying the development of HCC remains elusive. Long non‑coding ...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2019.4909
更新日期:2020-01-01 00:00:00
abstract::Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...
journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
doi:10.3892/ijo.2019.4874
更新日期:2019-12-01 00:00:00
abstract::177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4888
更新日期:2019-12-01 00:00:00
abstract::Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant behavior of renal cell carcinoma in vitro and in vivo. eIF3C expression was ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4903
更新日期:2019-12-01 00:00:00
abstract::DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to be elucidated. In current study, using the publicly available lu...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4899
更新日期:2019-12-01 00:00:00
abstract::Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4873
更新日期:2019-11-01 00:00:00
abstract::Subsequently to the publication of the above paper, the authors have realized that Figs. 3 and 4 contained errors. Two sets of bands in Figs. 3D and 4B were erroneously placed during the process of figure preparation. In Fig. 3D, the β‑actin bands for the PANC‑1 and CFPAC‑1 cells were presented incorrectly, whereas in...
journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
doi:10.3892/ijo.2019.4871
更新日期:2019-11-01 00:00:00
abstract::Although peritoneal lavage with distilled water performed after surgery prevents peritoneal seeding, cancer cells may avoid rupture under mild hypotonicity through regulatory volume decrease (RVD), which is the homeostatic regulation of ion and water transport. The aim of the present study was to investigate the effec...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4853
更新日期:2019-10-01 00:00:00
abstract::Liposarcoma (LPS) is one of the most frequently reported type of soft‑tissue sarcoma (STS). Well‑differentiated (WD) LPS and dedifferentiated (DD) LPS are the two most common subtypes. Chemotherapy has been considered to be ineffective in LPS, and novel treatment agents are thus necessary. In this study, we reanalyzed...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4861
更新日期:2019-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4862
更新日期:2019-10-01 00:00:00