Selective uveal melanoma inhibition with calcium channel blockade.

abstract：:To determine the tissue specificity of the potential mutations in DNA polymerase beta (pol beta), alterations in the pol beta were examined in breast, prostate, and colorectal primary tumors. The pol beta is known to contribute to mammalian base excision repair and replication. Similar to colorectal cancer, a high occ...

journal_title：International journal of oncology

authors： Wang L,Banerjee S

更新日期：1995-02-01 00:00:00

abstract：:Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a major limitation for its clinical use. The mechanisms of TRAIL resistance have been mostly studied in the context of cell lines that are intrinsically resistant to TRAIL. However, little is known about the molecular alterations that con...

journal_title：International journal of oncology

authors： Ouyang W,Yang C,Zhang S,Liu Y,Yang B,Zhang J,Zhou F,Zhou Y,Xie C

更新日期：2013-02-01 00:00:00

abstract：:The effects of pretreatment with the multidrug resistance (MDR) modulators verapamil (VPM), tamoxifen (TMX), cyclosporin A (CsA), and SDZ PSC833 (PSC) on drug sensitivity of the P-glycoprotein (Pgp) expressing human ileocecal carcinoma cell line HCT-8 is described. Following pretreatment of 2, 16 and 48 h with the ind...

journal_title：International journal of oncology

authors： Haberl I,Swatonek H,Schaufler K,Ulsperger E,Wenzl E,Theyer G,Hamilton G,Thalhammer T

更新日期：1998-05-01 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II)/IGF2R signaling plays a pivotal role in cell growth, migration and differentiation in many malignancies. An individual with high IGF-II expression levels has a high risk of developing cancer, but IGF2R is often considered to be a tumor suppressor. To date, little has been reporte...

journal_title：International journal of oncology

authors： Ou JM,Lian WS,Qiu MK,Dai YX,Dong Q,Shen J,Dong P,Wang XF,Liu YB,Quan ZW,Fei ZW

更新日期：2014-09-01 00:00:00

abstract：:Ganoderma lucidum (Curt.:Fr.) P. Karst, a medicinal fungus, has been widely used in Asian countries for centuries to prevent or treat a variety of diseases, including cancer. However, the mechanisms responsible for the effects of G. lucidum on cancer cells remain to be elucidated. We have previously shown that ethyl a...

journal_title：International journal of oncology

authors： Zaidman BZ,Wasser SP,Nevo E,Mahajna J

更新日期：2007-10-01 00:00:00

abstract：:TP53 gene, encoding tumor protein P53, is frequently inactivated in various types of human cancer, including colorectal, lung, and gastric cancer. Cancer cells with TP53 mutation acquire malignant potentials, such as selective growth advantage, genomic instability, resistance to apoptosis, and promotion of angiogenesi...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-07-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:Three novel isoforms of the neurofibromatosis 2 (NF2) gene transcripts generated from alternative splicing were identified from normal human brain, schwannoma and glioma tissues. The 3 novel transcripts lack exon 2, exons 2 and 3, exons 2-4, respectively. Recombinant isoform proteins encoded by those new transcripts h...

journal_title：International journal of oncology

authors： Nishi T,Takeshima H,Hamada K,Yoshizato K,Koga H,Sato K,Yamamoto K,Kitamura I,Kochi M,Kuratsu J,Saya H,Ushio Y

更新日期：1997-05-01 00:00:00

abstract：:Ophiopogonin B (OP-B), a saponin compound isolated from Radix Ophiopogon japonicus, was verified to inhibit cell proliferation in numerous non-small cell lung cancer (NSCLC) cells in our previous study. However, the precise mechanisms of action have remained unclear. In the present study, we mainly investigated the ef...

journal_title：International journal of oncology

authors： Chen M,Guo Y,Zhao R,Wang X,Jiang M,Fu H,Zhang X

更新日期：2016-07-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...

journal_title：International journal of oncology

authors： Yin F,Liu X,Li D,Wang Q,Zhang W,Li L

更新日期：2013-04-01 00:00:00

abstract：:The two-kringle domain of tissue-type plasminogen activator (TK1-2) has been identified as a novel angiogenesis inhibitor. In the previous study, purified Pichia-derived TK1-2 has been shown to suppress in vivo growth of human lung and colon cancer cells. Here, we demonstrate that E. coli-derived non-glycosylated TK1-...

journal_title：International journal of oncology

authors： Kang BH,Shim BS,Lee SY,Lee SK,Hong YK,Joe YA

更新日期：2006-02-01 00:00:00

abstract：:Numerous dietary phytochemicals have shown anti-breast carcinogenic activities when tested in vitro; however, in most cases, the demonstrated efficacy of individual phytochemicals requires doses not readily achievable in vivo. Therefore, whether diets might exert translational promises and benefits in clinical setting...

journal_title：International journal of oncology

authors： Hsieh TC,Wu JM

更新日期：2008-10-01 00:00:00

abstract：:Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hal...

journal_title：International journal of oncology

authors： Pak SH,Joung YH,Park JH,Lim EJ,Darvin P,Na YM,Hong DY,Lee B,Hwang TS,Park T,Ye SK,Moon ES,Cho BW,Park KD,Lee HK,Chung IM,Yang YM

更新日期：2012-07-01 00:00:00

abstract：:We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and...

journal_title：International journal of oncology

authors： Maruiwa M,Yano H,Fukuda K,Ogasawara S,Hisaka T,Yamaguchi R,Kojiro M

更新日期：1996-06-01 00:00:00

abstract：:We analyzed the representation of CD44 isoforms with both exons v9 and v10 among CD44 total amount and also examined correlation between their expression, clinical parameters and survival. We used a semi-quantitative RT-PCR reaction and a panel of 25 normal breast specimens, 10 mammary fibroadenomas, 8 cystic samples ...

journal_title：International journal of oncology

authors： Guriec N,Gairard B,Marcellin L,Wilk A,Calderoli H,Renaud R,Bergerat J,Oberling F

更新日期：1997-01-01 00:00:00

abstract：:Following the publication of this article, the authors noted that there was an error in the affiliations. Specifically, the affiliation of the first author JUAN XU should be: Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China. [the original article was publis...

journal_title：International journal of oncology

authors： Xu J,Jiang N,Shi H,Zhao S,Yao S,Shen H

更新日期：2017-06-01 00:00:00

abstract：:Pyrogallol (PG) inhibits the growth of various cells via stimulating O2•--mediated death. This study investigated the effects of PG on cell death in human pulmonary fibroblast (HPF) cells in relation to reactive oxygen species (ROS) and glutathione (GSH) levels. PG inhibited the growth of HPF cells with an IC50 of ~50...

journal_title：International journal of oncology

authors： Park WH

更新日期：2016-08-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth an...

journal_title：International journal of oncology

authors： Liu J,Zhen YZ,Cui J,Hu G,Wei J,Xu R,Tu P,Lin YJ

更新日期：2018-11-01 00:00:00

abstract：:Observational, clinical and experimental studies have suggested that dietary supplementation with selenium can inhibit the development of colon cancer. Since toxicity and chemopreventive efficacy of selenium compounds depend to a large extent, on the form of selenium the development of efficacious organoselenium compo...

journal_title：International journal of oncology

authors： Kawamori T,El-Bayoumy K,Ji BY,Rodriguez JG,Rao CV,Reddy BS

更新日期：1998-07-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:Many genes that are frequently mutated in human cancer are known to be involved in the control of normal cellular proliferation. One of the genes involved in DNA mismatch repair is hMLH1, defective mutations of which are found in some familial and various sporadic cancers. Although the DNA mismatch repair activity of ...

journal_title：International journal of oncology

authors： Shin KH,Han HJ,Park JG

更新日期：1998-03-01 00:00:00

abstract：:Hypoxia, a common phenomenon during the development of malignant solid tumors including breast cancer, serves to propagate a cascade of molecular pathways triggered by hypoxia-inducible factor-1α (HIF-1α). Carbonic anhydrase IX (CA IX), one of the target genes of HIF-1α, has been reported to be involved in progression...

journal_title：International journal of oncology

authors： Chu CY,Jin YT,Zhang W,Yu J,Yang HP,Wang HY,Zhang ZJ,Liu XP,Zou Q

更新日期：2016-01-01 00:00:00

abstract：:We investigated the clinical significance of the expression levels of matrix metalloproteinase 9 (MMP-9) in renal cell carcinoma (RCC). In addition, we validated the efficacy of pyrrole imidazole polyamide (PIP) targeting MMP-9 on inhibiting proliferation and invasion of RCC. We evaluated the expression levels of MMP-...

journal_title：International journal of oncology

authors： Sato A,Nagase H,Obinata D,Fujiwara K,Fukuda N,Soma M,Yamaguchi K,Kawata N,Takahashi S

更新日期：2013-11-01 00:00:00

abstract：:Clinical trials using antiangiogenic drugs revealed their potential against cancer. Unfortunately, a large percentage of patients does not yet benefit from this therapeutic approach highlighting the need of diagnostic tools to non-invasively evaluate and monitor response to therapy. It would also allow to predict whic...

journal_title：International journal of oncology

authors： Taurone S,Galli F,Signore A,Agostinelli E,Dierckx RA,Minni A,Pucci M,Artico M

更新日期：2016-08-01 00:00:00

abstract：:Accumulating evidence indicates that microRNAs (miRNAs) have a critical role in cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, the effect of miR‑300 on the development and progression of HCC remains unclear. In the present study, it was observed that miRNA (miR)‑300 expression was signif...

journal_title：International journal of oncology

authors： Chen Y,Guo Y,Li Y,Yang J,Liu J,Wu Q,Wang R

更新日期：2019-04-01 00:00:00

abstract：:Integrins are adhesion receptors involved in bidirectional signaling and are crucial for various cellular responses during normal homeostasis and pathological conditions, such as cancer progression and metastasis. In the present study, we demonstrated that blockage of β3 integrin-mediated cell- extracellular matrix in...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2016-03-01 00:00:00

abstract：:Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vecto...

journal_title：International journal of oncology

authors： Yamanaka R

更新日期：2004-04-01 00:00:00

abstract：:A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...

journal_title：International journal of oncology

authors： Ise W,Heuser M,Sanders K,Beck J,Gekeler V

更新日期：1996-05-01 00:00:00

abstract：:Cutaneous infantile hemangioma progresses through proliferation and involution phases. Since treatment with interferon, a negative regulator of angiogenesis, accelerates the involution phase, we hypothesized that cutaneous infantile hemangioma is associated with an imbalance between endogenous positive and negative re...

journal_title：International journal of oncology

authors： Bielenberg DR,Bucana CD,Sanchez R,Mulliken JB,Folkman J,Fidler IJ

更新日期：1999-03-01 00:00:00