Abstract:
:Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug resistance have rarely been studied. We performed a comprehensive bioinformatic analysis consisting of motif analysis, literature co-occurrence, gene/protein-gene/protein interaction network, protein-small molecule interaction network, and microRNAs enrichments which revealed that CCL21 and SPARCL1 directly or indirectly interact with a number of genes, proteins, small molecules and pathways associated with drug resistance in ovarian and other cancers. These results suggested that CCL21 and SPARCL1 may contribute to drug resistance in ovarian cancer. This study provided important information for further investigation of drug resistance-related functions of CCL21 and SPARCL1 in ovarian cancer.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Yin F,Liu X,Li D,Wang Q,Zhang W,Li Ldoi
10.3892/ijo.2013.1819subject
Has Abstractpub_date
2013-04-01 00:00:00pages
1305-16issue
4eissn
1019-6439issn
1791-2423journal_volume
42pub_type
杂志文章abstract::We examined the relationships among nuclear DNA content, tumor origin, nuclear size, and prognosis in squamous cell lung cancer. Central tumors had significantly higher DNA aneuploidy (83%, p<0.01) and DNA indices (1.65+/-0.40, p<0.01) than did peripheral tumors (40%, 1.29+/-0.37, respectively). All six women in the s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.1.3.325
更新日期:1992-08-01 00:00:00
abstract::In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4554
更新日期:2018-11-01 00:00:00
abstract::PTEN, a gene encoding a dual specificity phosphatase, is frequently altered in endometrial carcinoma. Moreover, these alterations are observed even in atypical hyperplasia of the endometrium. This evidence suggests that mutation of PTEN is an early genetic alteration involved in endometrial carcinogenesis. Adenovirus-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.15.6.1069
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.5.961
更新日期:1997-05-01 00:00:00
abstract::Hypericin is used as a powerful naturally occurring photosensitizer in photodynamic therapy (PDT). Activated by visible light, it kills tumour cells and tissues via generation of reactive oxygen species (ROS). Depending on the protocol, apoptotic cell death can be achieved very effectively by hypericin-PDT. To analyze...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::RSK2 (90 kDa ribosomal S6 kinase) is a downstream effector of the Ras/ERK (extracellular signal-regulated kinase) signaling pathway that has major functions in cell biological activities, including regulating nuclear signaling, cell cycle progression, cell proliferation, cell growth, protein synthesis, cell migration ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3481
更新日期:2016-06-01 00:00:00
abstract::Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome that is the main cause of inherited clear-cell renal cell carcinoma (ccRCC), which generally occurs in the form of multiple recurrent synchronized tumors. Affected patients are carriers of a germline mutation in the VHL tumor suppressor gene. Somati...
journal_title:International journal of oncology
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更新日期:2018-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.1.175
更新日期:2001-07-01 00:00:00
abstract::HeLa cell cultures were used as model systems for small interfering RNA (siRNA) induced knockdown of mRNA expression of the human telomerase catalytic subunit, telomerase reverse transcriptase (hTERT). Four 21-bp siRNAs targeting different sites of the hTERT mRNA were designed, and the siRNA molecules produced by a T7...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRR...
journal_title:International journal of oncology
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doi:10.3892/ijo.2014.2418
更新日期:2014-07-01 00:00:00
abstract::Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2519
更新日期:2014-09-01 00:00:00
abstract::Seventy French high-risk families were screened for germ-line BRCA-1 mutations. The BRCA-1 coding region and the exon-intron boundaries were sequenced, except when pre-screening by PTT revealed a truncated protein in exon 11. Germ-line BRCA-1 mutations were detected in 24% of families. The number of breast and ovarian...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.5.971
更新日期:1999-05-01 00:00:00
abstract::Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000720
更新日期:2010-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2391
更新日期:2014-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.2.395
更新日期:1997-02-01 00:00:00
abstract::Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2873
更新日期:2015-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4488
更新日期:2018-10-01 00:00:00
abstract::Human carcinogenesis is a multistep process in which epithelial cells progress through a series of premalignant phenotypes until an invasive cancer emerges. Extensive experimental observations in carcinogenesis have demonstrated this process can be divided into three general eras: initiation, promotion, and progressio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::A long-held central dogma of radiation biology has been that the carcinogenic effects of ionizing radiation (IR) are induced by the direct and radiolytic actions of IR on nuclear DNA. Numerous investigations, however, have revealed that several cancer relevant effects of IR can occur in cells that have received only c...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
abstract::HER-2/neu status and t-PA, u-PA, and PAI-1 cytosol content were evaluated in 88 primary breast cancer patients to determine the relationships between these parameters. HER-2/neu was amplified in 24% (20/84) of tumor samples and overexpressed in 28% (14/50). In the overall series, median t-PA, u-PA and PAI-1 contents, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::No population-based study has been conducted on the relationship between chemotherapy and the risk of cognitive impairments in patients with colorectal cancer. This study aimed to determine this association in a large population-based cohort of patients. We studied 72,374 men and women who were diagnosed with stages I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1882
更新日期:2013-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.4.749
更新日期:2001-10-01 00:00:00
abstract::Dose is a critical determinant of the efficacy of chemotherapy. The dose response curve for virtually all anticancer agents is steep in both in vitro and in vivo experimental studies. However the application of the steep dose-response curve in the clinic has been troublesome for many years because of dose limiting bon...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.3.439
更新日期:1996-03-01 00:00:00
abstract::Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...
journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2605
更新日期:2014-11-01 00:00:00