Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:There is emerging evidence for the prognostic role of various microRNA (miRNA) molecules in colon cancer. The aim of this study was therefore to compare the miRNA profiles in the primary tumor of patients with recurrent and non-recurrent colon cancer. The study population included 110 patients, 51 (46%) with stage I a...

journal_title：International journal of oncology

authors： Weissmann-Brenner A,Kushnir M,Lithwick Yanai G,Aharonov R,Gibori H,Purim O,Kundel Y,Morgenstern S,Halperin M,Niv Y,Brenner B

更新日期：2012-06-01 00:00:00

abstract：:The effects of different substrate stiffness were investigated on epithelial-mesenchymal transition (EMT) of cervical cancer cell lines and the role of miR-106b and its target protein DAB2 therein. Cervical cancer cell lines HeLa and SiHa were cultured on artificial substrates with different stiffness prepared using d...

journal_title：International journal of oncology

authors： Piao J,You K,Guo Y,Zhang Y,Li Z,Geng L

更新日期：2017-06-01 00:00:00

abstract：:Neuroblastoma, originated from neural crest cells, is the most common extracranial solid tumor in childhood. In the present study, we evaluated in vitro the oncolytic effect of live-attenuated poliovirus on human neuroblastoma cell lines, and in vivo its therapeutic efficacy in human neuroblastoma-bearing athymic mice...

journal_title：International journal of oncology

authors： Toyoda H,Ido M,Hayashi T,Gabazza EC,Suzuki K,Kisenge RR,Kang J,Hori H,Komada Y

更新日期：2004-01-01 00:00:00

abstract：:Neuroblastoma is a paediatric solid tumor characterized by recurrent genomic abnormalities of prognostic importance. One of the most commonly observed abnormalities is deletion of the short arm of chromosome 1 and reduced expression of cancer related genes in this chromosomal arm. The long isoform of the retinoblastom...

journal_title：International journal of oncology

authors： Geli J,Kiss N,Kogner P,Larsson C

更新日期：2010-11-01 00:00:00

abstract：:Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...

journal_title：International journal of oncology

authors： Williams J,Maitland N,Mott M,Brown K

更新日期：1992-12-01 00:00:00

abstract：:Glioma is the most prevalent and fatal primary tumor of the central nervous system in adults, while the development of effective therapeutic strategies in clinical practice remain a challenge. Nucleotide-binding domain leucine-rich family pyrin-containing 3 (NLRP3) has been reported to be associated with tumorigenesis...

journal_title：International journal of oncology

authors： Yin XF,Zhang Q,Chen ZY,Wang HF,Li X,Wang HX,Li HX,Kang CM,Chu S,Li KF,Li Y,Qiu YR

更新日期：2018-09-01 00:00:00

abstract：:MicroRNAs (miRs) are short non-coding single stranded RNAs regulating the translation of target mRNAs in normal and cancer cells in which they are frequently dysregulated promoting tumor progression. Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC), identified by aldehyde-dehydrogenase express...

journal_title：International journal of oncology

authors： Sun Z,Hu W,Xu J,Kaufmann AM,Albers AE

更新日期：2015-10-01 00:00:00

abstract：:We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...

journal_title：International journal of oncology

authors： Hartmann K,Teckentrup R,Nixdorf D,Meuer S,Papa V,Heinrich U

更新日期：1993-06-01 00:00:00

abstract：:The purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (IAPs), their inhibitor, Smac, and the focal adhesion kinase (FAK) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, NCCIT. We demonstrated that specifically in laminin-adheren...

journal_title：International journal of oncology

authors： Andjilani M,Droz JP,Benahmed M,Tabone E

更新日期：2006-02-01 00:00:00

abstract：:p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, able to prevent the CDK2/cyclin E induced retinoblastoma protein (pRB) phosphorylation, thus inhibiting cell cycle progression at G1 phase. p21WAF1/CIP1 protein levels were examined in a series of 102 ovarian tissue samples including normal ovary, primary ov...

journal_title：International journal of oncology

authors： Ferrandina G,Stoler A,Fagotti A,Fanfani F,Sacco R,De Pasqua A,Mancuso S,Scambia G

更新日期：2000-12-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target for anticancer drug design. However, few reports have described the constitutive activation of STAT3 in human sarcoma cells. In this study, we demonstrate that t...

journal_title：International journal of oncology

authors： Wei CC,Ball S,Lin L,Liu A,Fuchs JR,Li PK,Li C,Lin J

更新日期：2011-01-01 00:00:00

abstract：:We examined the relationships among nuclear DNA content, tumor origin, nuclear size, and prognosis in squamous cell lung cancer. Central tumors had significantly higher DNA aneuploidy (83%, p<0.01) and DNA indices (1.65+/-0.40, p<0.01) than did peripheral tumors (40%, 1.29+/-0.37, respectively). All six women in the s...

journal_title：International journal of oncology

authors： Miyamoto H,Isobe H,Akita H,Ishiguro A,Endo T,Inoue S,Kawakami Y

更新日期：1992-08-01 00:00:00

abstract：:WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A, and demonstrated up-regulation of WNT10A in gastric cancer. Here, we investigated expression of WNT10A mRNA in various types of human cancer. WNT10A mRNA was detected in 10 out of 12 esophageal ...

journal_title：International journal of oncology

authors： Kirikoshi H,Inoue S,Sekihara H,Katoh M

更新日期：2001-11-01 00:00:00

abstract：:Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...

journal_title：International journal of oncology

authors： Ahmad SS,Glatzle J,Bajaeifer K,Bühler S,Lehmann T,Königsrainer I,Vollmer JP,Sipos B,Ahmad SS,Northoff H,Königsrainer A,Zieker D

更新日期：2013-08-01 00:00:00

abstract：:Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the progression and growth of pancreatic cancer using the simultaneous administration of agents that inhibit the function of both targets, should be considered. In the pres...

journal_title：International journal of oncology

authors： Ding N,Cui XX,Gao Z,Huang H,Wei X,Du Z,Lin Y,Shih WJ,Rabson AB,Conney AH,Hu C,Zheng X

更新日期：2014-06-01 00:00:00

abstract：:Progression of oral carcinomas associates with aberrant activation and inactivation of molecules that work in established or unknown pathways. Although mucosa‑associated lymphoid tissue 1 (MALT1) expressed in normal oral epithelium is inactivated in the aggressive subset of carcinomas with worse prognosis, phenotypic ...

journal_title：International journal of oncology

authors： Kawamoto Y,Ohyama Y,Chiba T,Yagishita H,Sakashita H,Imai K

更新日期：2013-09-01 00:00:00

abstract：:Gene amplification is a frequent event in lung cancer, specifically in squamous cell lung carcinoma. Recently, we reported amplifications on chromosomal bands 3q26.1-q26.3 with the genes BCHE and SLC2A2 amplified in 40% of squamous cell lung carcinomas. Here, we identified an amplified domain within chromosomal bands ...

journal_title：International journal of oncology

authors： Rácz A,Brass N,Höfer M,Sybrecht GW,Remberger K,Meese EU

更新日期：2000-07-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. Genetic polymorphisms that decrease MTHFR activity result in an altered cancer risk depending on folic acid intake. In this study we examined the C677T an...

journal_title：International journal of oncology

authors： Singal R,Ferdinand L,Das PM,Reis IM,Schlesselman JJ

更新日期：2004-11-01 00:00:00

abstract：:We previously reported in a retrospective study that CEA-based RT-PCR was useful for predicting the prognosis of patients with node-negative colorectal cancer. RT-PCR is well established for laboratory use, but many issues remain to be resolved prior to its clinical application. In addition to the false positive rate ...

journal_title：International journal of oncology

authors： Takayama O,Yamamoto H,Ikeda K,Ishida H,Kato T,Okuyama M,Kanou T,Fukunaga M,Tominaga S,Morita S,Fujie Y,Fukunaga H,Ikenaga M,Ikeda M,Ohue M,Sekimoto M,Kikkawa N,Monden M

更新日期：2004-09-01 00:00:00

abstract：:Interleukin (IL)-4 and IL-10 have a wide variety of activities in the immune system. We re-evaluated the action of IL-4 and IL-10 on human blood monocytes, myeloid dendritic cell (DC1) precursors, using a serum-free culture system. Both IL-4 and IL-10 inhibited the survival of CD14+ monocytes supported by granulocyte-...

journal_title：International journal of oncology

authors： Miyashita H,Katayama N,Fujieda A,Shibasaki T,Yamamura K,Sugimoto Y,Miyata E,Ohishi K,Nishii K,Masuya M,Shiku H

更新日期：2005-03-01 00:00:00

abstract：:Women from ethnic minority groups, including immigrants and refugees are reported to have low breast cancer (BC) screening rates. Active, culturally-sensitive outreach is vital for increasing participation of these women in BC screening programs. Women at high BC risk and who belong to an ethnic minority group are of ...

journal_title：International journal of oncology

authors： Belkić K,Cohen M,Wilczek B,Andersson S,Berman AH,Márquez M,Vukojević V,Mints M

更新日期：2015-09-01 00:00:00

abstract：:Retinoids, which include vitamin A (retinol) and its derivatives, have previously been investigated as potential chemopreventive and chemotherapeutic agents in bladder cancer. We examined mRNA expression of the retinoid receptors RARalpha, RARbeta2, RARgamma and RXRalpha, as well as two putative RARbeta2 target genes,...

journal_title：International journal of oncology

authors： Boorjian S,Scherr DS,Mongan NP,Zhuang Y,Nanus DM,Gudas LJ

更新日期：2005-04-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a major cause of cancer deaths. Concurrent administration of radiation and chemotherapy is the treatment of choice for advanced NPC. Previously, we showed that apogossypolone (ApoG2) induced apoptosis by blocking the binding of Bcl-2 to Bax, arresting the cell cycle in the S phase, in...

journal_title：International journal of oncology

authors： He JH,Liao XL,Wang W,Li DD,Chen WD,Deng R,Yang D,Han ZP,Jiang JW,Zhu XF

更新日期：2014-09-01 00:00:00

abstract：:Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prost...

journal_title：International journal of oncology

authors： Li H,Gu Y,Miki J,Hukku B,McLeod DG,Hei TK,Rhim JS

更新日期：2007-09-01 00:00:00

abstract：:Dickkopf‑related protein 3 (DKK3), which is a member of the Dickkopf WNT signaling pathway inhibitor family, is considered to be a tumor suppressor, due to its reduced expression in cancer cells and its ability to induce apoptosis when overexpressed by adenovirus. However, our previous study demonstrated alternative f...

journal_title：International journal of oncology

authors： Katase N,Nishimatsu SI,Yamauchi A,Yamamura M,Fujita S

更新日期：2019-03-01 00:00:00

abstract：:It has been reported that MUC-1 molecules devoid of the tandem repeat region (MUC-1/Y) are detected preferentially in carcinoma cells and are associated with their progression. However, its clinical significance is still unknown. We constructed a mouse colon adenocarcinoma cell line (MC-38) transduced with either MUC-...

journal_title：International journal of oncology

authors： Akagi J,Takai E,Tamori Y,Nakagawa K,Ogawa M

更新日期：2001-05-01 00:00:00

abstract：:The assembly of trans-acting proteins on sequence-specific DNA cis-elements is crucial in the regulation of eukaryotic gene expression. Far upstream element binding proteins (FAB) are proteins that regulate the expression of the c-myc oncogene by binding to the far upstream element of the c-myc gene. The present study...

journal_title：International journal of oncology

authors： Engidawork E,Afjehi-Sadat L,Yang JW,Slavc I,Lubec G

更新日期：2006-09-01 00:00:00

abstract：:The cell-adhesion properties of cancer cells can be targeted to block cancer metastasis. Although cytosolic lysyl-tRNA synthetase (KRS) functions in protein synthesis, KRS on the plasma membrane is involved in cancer metastasis. We hypothesized that KRS is involved in cell adhesion-related signal transduction for cell...

journal_title：International journal of oncology

authors： Nam SH,Kang M,Ryu J,Kim HJ,Kim D,Kim DG,Kwon NH,Kim S,Lee JW

更新日期：2016-04-01 00:00:00

abstract：:The two-kringle domain of tissue-type plasminogen activator (TK1-2) has been identified as a novel angiogenesis inhibitor. In the previous study, purified Pichia-derived TK1-2 has been shown to suppress in vivo growth of human lung and colon cancer cells. Here, we demonstrate that E. coli-derived non-glycosylated TK1-...

journal_title：International journal of oncology

authors： Kang BH,Shim BS,Lee SY,Lee SK,Hong YK,Joe YA

更新日期：2006-02-01 00:00:00