Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer.

abstract：:Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. Transportation of LAPTM5 from Golgi to lysosome could be inhibit...

journal_title：International journal of oncology

authors： Chen L,Wang G,Luo Y,Wang Y,Xie C,Jiang W,Xiao Y,Qian G,Wang X

更新日期：2017-01-01 00:00:00

abstract：:Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the progression and growth of pancreatic cancer using the simultaneous administration of agents that inhibit the function of both targets, should be considered. In the pres...

journal_title：International journal of oncology

authors： Ding N,Cui XX,Gao Z,Huang H,Wei X,Du Z,Lin Y,Shih WJ,Rabson AB,Conney AH,Hu C,Zheng X

更新日期：2014-06-01 00:00:00

abstract：:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a ...

journal_title：International journal of oncology

authors： Park YK,Cho CH,Chi SG,Han CS,Ushigome S,Unni KK

更新日期：2001-10-01 00:00:00

abstract：:Lung cancer is a prevalent disease and is one of the leading causes of mortality worldwide. Despite the development of various anticancer drugs, the prognosis of lung cancer is relatively poor. Metastasis of lung cancer, as well as chemoresistance, is associated with a high mortality rate for patients with lung cancer...

journal_title：International journal of oncology

authors： Chiu YH,Hsu SH,Hsu HW,Huang KC,Liu W,Wu CY,Huang WP,Chen JY,Chen BH,Chiu CC

更新日期：2018-11-01 00:00:00

abstract：:Three novel isoforms of the neurofibromatosis 2 (NF2) gene transcripts generated from alternative splicing were identified from normal human brain, schwannoma and glioma tissues. The 3 novel transcripts lack exon 2, exons 2 and 3, exons 2-4, respectively. Recombinant isoform proteins encoded by those new transcripts h...

journal_title：International journal of oncology

authors： Nishi T,Takeshima H,Hamada K,Yoshizato K,Koga H,Sato K,Yamamoto K,Kitamura I,Kochi M,Kuratsu J,Saya H,Ushio Y

更新日期：1997-05-01 00:00:00

abstract：:Modulation of gene expression through histone deacetylase (HDAC) inhibition is considered a possible therapeutic strategy in acute myeloid leukaemia (AML). In vitro effects and basal gene expression of structurally different HDAC inhibitors were examined. Primary human AML cells were derived from 59 consecutive patien...

journal_title：International journal of oncology

authors： Stapnes C,Ryningen A,Hatfield K,Øyan AM,Eide GE,Corbascio M,Kalland KH,Gjertsen BT,Bruserud Ø

更新日期：2007-12-01 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-...

journal_title：International journal of oncology

authors： Ouelaa-Benslama R,De Wever O,Hendrix A,Sabbah M,Lambein K,Land D,Prévost G,Bracke M,Hung MC,Larsen AK,Emami S,Gespach C

更新日期：2012-07-01 00:00:00

abstract：:Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in r...

journal_title：International journal of oncology

authors： Tsukamoto S,Honoki K,Fujii H,Tohma Y,Kido A,Mori T,Tsujiuchi T,Tanaka Y

更新日期：2012-01-01 00:00:00

abstract：:The lack of good molecular markers for diagnosis as well as treatment assessment has rendered the hepatocellular carcinoma (HCC) a major challenge in health care. In this study, woodchucks were used as an animal model for hepatitis virus-induced HCC, and gene expression studies were performed using a human oligonucleo...

journal_title：International journal of oncology

authors： Wang F,Anderson PW,Salem N,Kuang Y,Tennant BC,Lee Z

更新日期：2007-01-01 00:00:00

abstract：:Tumor cell (TC) metastasis is initiated by selective adhesion of TCs to target structures such as basement membrane and endotheliaI cells (ECs), followed by transvascular migration of TCs. Variants of murine B16 melanoma having different metastatic potentials (in the order BL6 greater than or equal to F10>F1>WA4) have...

journal_title：International journal of oncology

authors： Otsuji E,Park Y,Tashiro K,Kojima N,Toyokuni T,Hakomori S

更新日期：1995-02-01 00:00:00

abstract：:We have demonstrated the possibility that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system might be involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). In order to further clarify the role of the SDF-1/CXCR4 system in oral SCC, we examined the expression of CXCR4...

journal_title：International journal of oncology

authors： Almofti A,Uchida D,Begum NM,Tomizuka Y,Iga H,Yoshida H,Sato M

更新日期：2004-07-01 00:00:00

abstract：:We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...

journal_title：International journal of oncology

authors： Kolzau T,Deppert W

更新日期：1993-07-01 00:00:00

abstract：:Hexadecylphosphocholine (HPC, D-18506, INN: Miltefosine) was characterized in a clonogenic micro assay in vitro with respect to its cytotoxicity against a panel of human and murine tumor cell lines and murine bone marrow cultures (GM-CFC). The KB human epithelial carcinoma line was found to be more sensitive by at lea...

journal_title：International journal of oncology

authors： Voegeli R,Echarti C,Maurer H,Stekar J,Hilgard P,Unger C

更新日期：1993-02-01 00:00:00

abstract：:The human prostate gland is a well known source of H1 and H2 relaxin but information is lacking on the expression and potential role of the INSL3 peptide hormone within the prostate gland. In the present study we have investigated the expression of human INSL3 in patients with benign prostate hyperplasia (BPH), prosta...

journal_title：International journal of oncology

authors： Klonisch T,Müller-Huesmann H,Riedel M,Kehlen A,Bialek J,Radestock Y,Holzhausen HJ,Steger K,Ludwig M,Weidner W,Hoang-Vu C,Hombach-Klonisch S

更新日期：2005-08-01 00:00:00

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:Paclitaxel (taxol) has been used for the treatment of various human tumors and is an exceedingly efficient chemotherapy agent against esophageal cancer. However, the precise molecular mechanisms of paclitaxel effects on human esophageal adenocarcinoma cells are not well understood. MTT assay and cell cycle analysis we...

journal_title：International journal of oncology

authors： Kim SJ,Chung MJ,Kim JS,Kim B,Park WH,Kim SH,Kim SZ,Lee JS,Kim SM

更新日期：2011-12-01 00:00:00

abstract：:Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...

journal_title：International journal of oncology

authors： Pereira MC,de Bessa-Garcia SA,Burikhanov R,Pavanelli AC,Antunes L,Rangnekar VM,Nagai MA

更新日期：2013-08-01 00:00:00

abstract：:MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate...

journal_title：International journal of oncology

authors： Xu X,Xia Y,Ma J,Li W,Niu N,Li X,Tao H,Xu J,He X

更新日期：2020-08-01 00:00:00

abstract：:Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (C...

journal_title：International journal of oncology

authors： Yu JH,Zheng JB,Qi J,Yang K,Wu YH,Wang K,Wang CB,Sun XJ

更新日期：2019-03-01 00:00:00

abstract：:Human breast cancer is a major cause of global morbidity and mortality in women and it is a process that involves numerous molecular and cellular alterations attributed to environmental substances and agents such as hormones. Bisphosphonates, such as pamidronate, are potent antiresorptive drugs used to the treatment o...

journal_title：International journal of oncology

authors： Ponce-Cusi R,Calaf GM

更新日期：2015-01-01 00:00:00

abstract：:Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the degradation of pyrimidines and pyrimidine base analogs including the anticancer drugs 5-fluorouracil (5-FU) and Xeloda. A decreased DPD enzyme activity has been described in cancer patients experiencing severe and life-threatening toxic...

journal_title：International journal of oncology

authors： Gross E,Seck K,Neubauer S,Mayr J,Hellebrand H,Ratanaphan A,Lutz V,Stockinger H,Kiechle M

更新日期：2003-02-01 00:00:00

abstract：:Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and is highly resistant to conventional cancer therapy. A better understanding of the regulatory mechanisms which control the growth of this deadly malignancy are urgently needed to develop more effective cancer intervention strategies. Recent studies h...

journal_title：International journal of oncology

authors： Schuller HM,Plummer HK 3rd,Bochsler PN,Dudric P,Bell JL,Harris RE

更新日期：2001-09-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:Dissemination of single tumor cells to the bone marrow is a common event in cancer. The clinical significance of cytokeratin-positive cells detected in the bone marrow of cancer patients is still a matter of debate. In gastric cancer, overexpression of the receptor (uPAR or CD87) for the serine protease urokinase-type...

journal_title：International journal of oncology

authors： Noack F,Helmecke D,Rosenberg R,Thorban S,Nekarda H,Fink U,Lewald J,Stich M,Schutze K,Harbeck N,Magdolen V,Graeff H,Schmitt M

更新日期：1999-10-01 00:00:00

abstract：:Oncogenic, moderately immunogenic MK16/1/IIIABC (MK16) cells were previously established by co-transfection of HPV 16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of the MK16 cells produced progressively growing neoplasms which metastasized spontaneously to lungs. In t...

journal_title：International journal of oncology

authors： Mendoza L,Bubeník J,Símová J,Jandlová T,Vonka V,Mikysková R

更新日期：2003-07-01 00:00:00

abstract：:CDH13 (H-cadherin) is a member of the cadherin superfamily, which plays an important role in cell recognition and adhesion. We examined the expression and methylation status of the CDH13 gene in diffuse large B cell lymphomas (B-DLCLs). We found decreased expression of the CDH13 gene in all of 6 hematopoietic cell lin...

journal_title：International journal of oncology

authors： Ogama Y,Ouchida M,Yoshino T,Ito S,Takimoto H,Shiote Y,Ishimaru F,Harada M,Tanimoto M,Shimizu K

更新日期：2004-09-01 00:00:00

abstract：:Retinoids, which include vitamin A (retinol) and its derivatives, have previously been investigated as potential chemopreventive and chemotherapeutic agents in bladder cancer. We examined mRNA expression of the retinoid receptors RARalpha, RARbeta2, RARgamma and RXRalpha, as well as two putative RARbeta2 target genes,...

journal_title：International journal of oncology

authors： Boorjian S,Scherr DS,Mongan NP,Zhuang Y,Nanus DM,Gudas LJ

更新日期：2005-04-01 00:00:00

abstract：:Telomerase activity and its subunits (hTERC, hTERT mRNA) were evaluated in ovarian tumours in relation to the expression of p53, c-Myc and estrogen receptor (ER). Furthermore, relations between telomerase activity, hTERC and hTERT with known clinicopathologic prognostic factors and survival in patients with malignant ...

journal_title：International journal of oncology

authors： Wisman GB,Hollema H,Helder MN,Knol AJ,Van der Meer GT,Krans M,De Jong S,De Vries EG,Van der Zee AG

更新日期：2003-11-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00