Antitumor activity of pamidronate in breast cancer cells transformed by low doses of α-particles and estrogen in vitro.

abstract：:Glioma is the most prevalent and fatal primary tumor of the central nervous system in adults, while the development of effective therapeutic strategies in clinical practice remain a challenge. Nucleotide-binding domain leucine-rich family pyrin-containing 3 (NLRP3) has been reported to be associated with tumorigenesis...

journal_title：International journal of oncology

authors： Yin XF,Zhang Q,Chen ZY,Wang HF,Li X,Wang HX,Li HX,Kang CM,Chu S,Li KF,Li Y,Qiu YR

更新日期：2018-09-01 00:00:00

abstract：:The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have evaluated the differential expression and subcellular localization of the functionally distinct apoptotic (TA) and anti-apoptotic (DeltaN) isoforms of p73 in non-small cell lung cancer (NSCLC), their possible association with p53 exp...

journal_title：International journal of oncology

authors： Di Vinci A,Sessa F,Casciano I,Banelli B,Franzi F,Brigati C,Allemanni G,Russo P,Dominioni L,Romani M

更新日期：2009-02-01 00:00:00

abstract：:In antibody-directed enzyme-prodrug therapy (ADEPT), an antibody-bound enzyme localizes to tumor tissue, where it selectively converts a subsequently administered non-toxic prodrug into a cytotoxic drug. A33scFv::CDy is a bifunctional fusion construct comprising a single chain antibody against the gpA33 antigen and th...

journal_title：International journal of oncology

authors： Panjideh H,Da Silva Coelho VC,Dernedde J,Bachran C,Förster GJ,Franke J,Fasold P,Fuchs H,Thiel E,Deckert PM

更新日期：2008-04-01 00:00:00

abstract：:Dickkopf-1 (Dkk1), a negative regulator of the Wnt signaling pathway, is implicated in tumorigenesis in several types of cancer. The purpose of this study was to determine the involvement of Dkk1 in oral squamous cell carcinoma (OSCC). We found that Dkk1 is frequently upregulated in OSCC-derived cell lines and primary...

journal_title：International journal of oncology

authors： Ogoshi K,Kasamatsu A,Iyoda M,Sakuma K,Yamatoji M,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K

更新日期：2011-08-01 00:00:00

abstract：:Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. We have previously reported that HBXIP promotes the proliferation and migration of breast cancer cells. S-phase kinase-associated protein 2 (Skp2) is another oncoprotein which is important for migration. In this study, we investigated whether Skp2 is in...

journal_title：International journal of oncology

authors： Xu F,Zhu X,Han T,You X,Liu F,Ye L,Zhang X,Wang X,Yao Y

更新日期：2014-07-01 00:00:00

abstract：:The p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation. There are several reports that the reintroduction of the p16INK4A gene into p16(-) NSCLC cells results i...

journal_title：International journal of oncology

authors： Sumitomo K,Shimizu E,Shinohara A,Yokota J,Sone S

更新日期：1999-06-01 00:00:00

abstract：:Gastric carcinoma is the most common cancer and the second most common cause of cancer-related death in Korea. Many studies have been reported regarding prognostic factors. Among the category I prognostic factors of gastric carcinoma, lymph node metastasis (nodal status) is considered to be the strongest prognostic fa...

journal_title：International journal of oncology

authors： Lee SY,Hwang I,Park YS,Gardner J,Ro JY

更新日期：2010-06-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Acquired drug resistance to chemotherapy is a major problem in the treatment of cancer. After primary surgical intervention, followed by chemotherapy treatments, the majority of patients develop disease recurrence. This is due to tumor cell heterogeneity and genetic instability. In contrast to tumor cells, proliferati...

journal_title：International journal of oncology

authors： Benouchan M,Colombo BM

更新日期：2005-08-01 00:00:00

abstract：:The molecular mechanism playing a role in the development of benign prostate hypertrophy (BPH) and prostate cancer (PC) is not well defined. We performed microarray analysis to assess the gene expression change in BPH and PC, and performed network analysis. Normal prostate, BPH and PC tissues were obtained from patien...

journal_title：International journal of oncology

authors： Endo T,Uzawa K,Suzuki H,Tanzawa H,Ichikawa T

更新日期：2009-09-01 00:00:00

abstract：:Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypoxia is involved in ...

journal_title：International journal of oncology

authors： Kogita A,Togashi Y,Hayashi H,Sogabe S,Terashima M,De Velasco MA,Sakai K,Fujita Y,Tomida S,Takeyama Y,Okuno K,Nakagawa K,Nishio K

更新日期：2014-10-01 00:00:00

abstract：:There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-κB. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been perform...

journal_title：International journal of oncology

authors： Huang J,Guo P,Ma D,Lin X,Fang Q,Wang J

更新日期：2016-07-01 00:00:00

abstract：:miRNA‑223 (miR‑223) has been reported to function not only as a tumor suppressor, but also as an oncogenic microRNA (miRNA or miR) in various cancer cells. Therefore, the functional role of miR‑223 has not been elucidated to date, at least to the best of our knowledge. We previously performed the deep sequencing analy...

journal_title：International journal of oncology

authors： Sugita S,Yoshino H,Yonemori M,Miyamoto K,Matsushita R,Sakaguchi T,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2019-06-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00

abstract：:Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...

journal_title：International journal of oncology

authors： Lin C,Tsai SC,Tseng MT,Peng SF,Kuo SC,Lin MW,Hsu YM,Lee MR,Amagaya S,Huang WW,Wu TS,Yang JS

更新日期：2013-03-01 00:00:00

abstract：:Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...

journal_title：International journal of oncology

authors： Wada H,Yamamoto H,Kim C,Uemura M,Akita H,Tomimaru Y,Hama N,Kawamoto K,Kobayashi S,Eguchi H,Umeshita K,Doki Y,Mori M,Nagano H

更新日期：2014-09-01 00:00:00

abstract：:Prostate cancer is initially sensitive to hormone therapy; however, over time the majority of patients progress to a hormone-insensitive form classified as castration-resistant prostate cancer (CRPC). CRPC is highly metastatic and patients have a poor prognosis. Thus, new drugs for the treatment of this disease are re...

journal_title：International journal of oncology

authors： Chen S,Nimick M,Cridge AG,Hawkins BC,Rosengren RJ

更新日期：2018-02-01 00:00:00

abstract：:Hypoxia is an important factor of tumor microenvironment that significantly influences behaviour of tumor cells via activation of genes whose products are involved in adaptation to hypoxic stress, such as vascular endothelial growth factor (VEGF) and glucose transporter (GLUT-1). Carbonic anhydrase IX (CA IX) is one o...

journal_title：International journal of oncology

authors： Rafajová M,Zatovicová M,Kettmann R,Pastorek J,Pastoreková S

更新日期：2004-04-01 00:00:00

abstract：:In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth an...

journal_title：International journal of oncology

authors： Liu J,Zhen YZ,Cui J,Hu G,Wei J,Xu R,Tu P,Lin YJ

更新日期：2018-11-01 00:00:00

abstract：:Gastric carcinoma may occur sporadically or in association with hereditary diseases, such as Peutz-Jehgers syndrome (PJS). The PJS gene (named STK11 or LKB1) was mapped to 19p13.3 and recently cloned. Germ-line mutations of the gene have been detected in familial PJS patients and are predicted to predispose STK11 carr...

journal_title：International journal of oncology

authors： Park WS,Moon YW,Yang YM,Kim YS,Kim YD,Fuller BG,Vortmeyer AO,Fogt F,Lubensky IA,Zhuang Z

更新日期：1998-09-01 00:00:00

abstract：:Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon alpha (IFN-alpha) as a single agent or combined with standard chemo-therapy has been shown to inhibit various tumors, but the effect of combination anti-angiog...

journal_title：International journal of oncology

authors： Son MJ,Song HS,Kim MH,Kim JT,Kang CM,Jeon JW,Park SY,Kim YJ,Groves MD,Park K,Kim JH,Nam DH

更新日期：2006-06-01 00:00:00

abstract：:Angiogenesis plays a critical role in the development of solid tumors by supplying nutrients and oxygen to support continuous growth of tumor as well as providing an avenue for hematogenous metastasis. Tumor angiogenesis is highly regulated by multiple intracellular signaling transduction cascades such as Hedgehog, ST...

journal_title：International journal of oncology

authors： Lin J,Chen Y,Wei L,Hong Z,Sferra TJ,Peng J

更新日期：2013-11-01 00:00:00

abstract：:The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of ...

journal_title：International journal of oncology

authors： Micallef M,Ariyasu T,Dao T,Matsuo Y,Minowada J

更新日期：1994-03-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:Aurora-A is involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and regards to an oncogene. Aurora-A is also known to bind to several other proteins affecting its up-regulation or down-regulation and localization. However, how these different binding signals work together to regulate Auro...

journal_title：International journal of oncology

authors： Lieu AS,Cheng TS,Chou CH,Wu CH,Hsu CY,Huang CY,Chang LK,Loh JK,Chang CS,Hsu CM,Howng SL,Hong YR

更新日期：2010-08-01 00:00:00

abstract：:Interleukin (IL)-4 and IL-10 have a wide variety of activities in the immune system. We re-evaluated the action of IL-4 and IL-10 on human blood monocytes, myeloid dendritic cell (DC1) precursors, using a serum-free culture system. Both IL-4 and IL-10 inhibited the survival of CD14+ monocytes supported by granulocyte-...

journal_title：International journal of oncology

authors： Miyashita H,Katayama N,Fujieda A,Shibasaki T,Yamamura K,Sugimoto Y,Miyata E,Ohishi K,Nishii K,Masuya M,Shiku H

更新日期：2005-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with broad resistance to chemotherapeutic drugs. Krüppel-like factor 4 (KLF4) is a candidate tumor suppressor in PDAC. However, the precise role of KLF4 in gemcitabine resistance of PDAC remains largely unclear. In this study, we demonstrat...

journal_title：International journal of oncology

authors： Wang Z,Chen Y,Lin Y,Wang X,Cui X,Zhang Z,Xian G,Qin C

更新日期：2017-10-01 00:00:00

abstract：:The potential of arsenic trioxide (As2O3) as a novel therapy against ovarian cancer has been progressively recognized. Its prospective usefulness for treatment of this malignancy either alone or in combination with other chemotherapeutic agents has been increasingly explored. In this study, we attempted to enhance the...

journal_title：International journal of oncology

authors： Ong PS,Chan SY,Ho PC

更新日期：2011-06-01 00:00:00

abstract：:177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...

journal_title：International journal of oncology

authors： Lundsten S,Spiegelberg D,Stenerlöw B,Nestor M

更新日期：2019-12-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00