Downregulation of LAPTM5 suppresses cell proliferation and viability inducing cell cycle arrest at G0/G1 phase of bladder cancer cells.

abstract：:All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein ...

journal_title：International journal of oncology

authors： Nutthasirikul N,Limpaiboon T,Leelayuwat C,Patrakitkomjorn S,Jearanaikoon P

更新日期：2013-04-01 00:00:00

abstract：:Magnolol, a neolignan from the traditional medicinal plant Magnolia obovata, has been shown to possess neuroprotective, anti-inflammatory, anticancer and anti-angiogenic activities. However, the precise mechanism of the anti-angiogenic activity of magnolol remains to be elucidated. In the present study, the anti-angio...

journal_title：International journal of oncology

authors： Kim GD,Oh J,Park HJ,Bae K,Lee SK

更新日期：2013-08-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, dr...

journal_title：International journal of oncology

authors： Suzuki Y,Inoue T,Murai M,Suzuki-Karasaki M,Ochiai T,Ra C

更新日期：2012-08-01 00:00:00

abstract：:Marek's disease virus (MDV) is one of the most oncogenic herpesviruses and the only cancer virus that has a successful vaccine. Based on the short-latency and polyclonal nature of the tumors, it is likely that MDV encodes its own oncogenes. Recent studies have provided insights into possible MDV genes involved in onco...

journal_title：International journal of oncology

authors： Kung H,Tanaka A,Nonoyama M

更新日期：1995-05-01 00:00:00

abstract：:One of the major obstacles in curing prostate cancer is the development of drug resistance. It is not only imperative to discover the molecular basis of resistance but also to find therapeutic agents that can disrupt the resistant pathways. Tumor necrosis factor TNF-related apoptosis-inducing ligand TRAIL-like ligands...

journal_title：International journal of oncology

authors： Festuccia C,Gravina GL,D'Alessandro AM,Millimaggi D,Di Rocco C,Dolo V,Ricevuto E,Vicentini C,Bologna M

更新日期：2008-08-01 00:00:00

abstract：:Normal human diploid cells have a limited life span and undergo replicative senescence after various limited population doublings. Cells must pass the senescence barrier to become immortal. The exact mechanisms of immortalization are not clear, although inactivation of the RB pathway, and/or the p53 pathway and activa...

journal_title：International journal of oncology

authors： Liu L,Zhang J,Bates S,Li JJ,Peehl DM,Rhim JS,Pfeifer GP

更新日期：2005-01-01 00:00:00

abstract：:Activation of intestinal human pregnane X receptor (PXR) has recently been proposed as a promising strategy for the chemoprevention of inflammation-induced colon cancer. The present study was aimed at evaluating the effect of rifaximin, a non-absorbable antibiotic, in inhibiting angiogenesis in a model of human colore...

journal_title：International journal of oncology

authors： Esposito G,Gigli S,Seguella L,Nobile N,D'Alessandro A,Pesce M,Capoccia E,Steardo L,Cirillo C,Cuomo R,Sarnelli G

更新日期：2016-08-01 00:00:00

abstract：:Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...

journal_title：International journal of oncology

authors： Yang YX,Li XL,Wang L,Han SY,Zhang YR,Pratheeshkumar P,Wang X,Lu J,Yin YQ,Sun LJ,Budhraja A,Hitron AJ,Ding SZ

更新日期：2013-09-01 00:00:00

abstract：:Obesity is considered a risk factor for many cancers, including breast cancer. Our laboratory has previously shown that leptin is mitogenic in many cancer cell lines, including breast. Information regarding the effects of high leptin levels on leptin receptor expression and signaling is lacking. The purpose of this st...

journal_title：International journal of oncology

authors： Frankenberry KA,Skinner H,Somasundar P,McFadden DW,Vona-Davis LC

更新日期：2006-04-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target for anticancer drug design. However, few reports have described the constitutive activation of STAT3 in human sarcoma cells. In this study, we demonstrate that t...

journal_title：International journal of oncology

authors： Wei CC,Ball S,Lin L,Liu A,Fuchs JR,Li PK,Li C,Lin J

更新日期：2011-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 20...

journal_title：International journal of oncology

authors： Mattern J,Koomagi R,Volm M

更新日期：1995-05-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:Tumor metastases are the ultimate target in cancer therapy. In epithelial malignancies, the expression of high-mobility-group A2 (HMGA2) is associated with disease progression and the epithelial-mesenchymal transition (EMT), which is involved in the metastatic process. The present study assessed the clinical and molec...

journal_title：International journal of oncology

authors： Lee J,Ha S,Jung CK,Lee HH

更新日期：2015-01-01 00:00:00

abstract：:Fatigue is one of the most common complaints of people with cancer. It affects the majority of patients actively undergoing cancer related therapies, but also a meaningful number of those who successfully completed therapy and are disease-free and potentially cured at the end of the treatments. In cancer setting, fati...

journal_title：International journal of oncology

authors： Tavio M,Milan I,Tirelli U

更新日期：2002-11-01 00:00:00

abstract：:The positron-emitting radiohalogens 18F, 75Br, 76Br, and 124I are reviewed regarding their relevance for positron emission tomography (PET) in oncology. Relevant production routes of these cyclotron-generated isotopes are given, followed by publications that deal with applications of these radiohalogens. This article ...

journal_title：International journal of oncology

authors： Glaser M,Luthra SK,Brady F

更新日期：2003-02-01 00:00:00

abstract：:Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the degradation of pyrimidines and pyrimidine base analogs including the anticancer drugs 5-fluorouracil (5-FU) and Xeloda. A decreased DPD enzyme activity has been described in cancer patients experiencing severe and life-threatening toxic...

journal_title：International journal of oncology

authors： Gross E,Seck K,Neubauer S,Mayr J,Hellebrand H,Ratanaphan A,Lutz V,Stockinger H,Kiechle M

更新日期：2003-02-01 00:00:00

abstract：:The anti-inflammatory effects of oridonin (Ordn) have been well established in previous studies. However, the apoptotic effects of Ordn on oral cancer cells have not yet been evaluated, at least to the best of our knowledge. The aim of this study was to examine the apoptotic activity of Ordn in oral squamous cell carc...

journal_title：International journal of oncology

authors： Oh HN,Seo JH,Lee MH,Yoon G,Cho SS,Liu K,Choi H,Oh KB,Cho YS,Kim H,Han AL,Chae JI,Shim JH

更新日期：2018-05-01 00:00:00

abstract：:Idarubicin (IDA) is a 4-demethoxy-anthracycline analogue of daunorubicin (DNR). IDA has been recognized as a potent anti-leukemic agent. However, the molecular mechanism of IDA-induced cell death remains unclear. In the present study, we investigated the activity of IDA to induce apoptosis in human leukemia HL-60 and ...

journal_title：International journal of oncology

authors： Qi SN,Yoshida A,Ueda T

更新日期：2003-05-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...

journal_title：International journal of oncology

authors： Wang H,Dai YY,Zhang WQ,Hsu PC,Yang YL,Wang YC,Chan G,Au A,Xu ZD,Jiang SJ,Wang W,Jablons DM,You L

更新日期：2017-07-01 00:00:00

abstract：:Lack of life-prolonging therapies has provided much of the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, the use of dietary supplements and botanical products has been showing a sustained increase in recent years, owing in part to some en...

journal_title：International journal of oncology

authors： Lu X,Hsieh TC,Wu JM

更新日期：2004-12-01 00:00:00

abstract：:Primary liver cancer is globally the sixth most frequent cancer, and the second leading cause of cancer death and its incidence is increasing in many countries, thus, becoming serious threat to human health. Substantial research has focused on the treatment and prevention of liver cancer. However, the underlying molec...

journal_title：International journal of oncology

authors： Hu B,Sun M,Liu J,Hong G,Lin Q

更新日期：2016-04-01 00:00:00

abstract：:One hundred and eighty-one breast cancer specimens were analyzed for nuclear p53 staining by immunochemical methods. There were 123 fine-needle cytological specimens and 58 frozen tissue sections of surgical biopsies. The microscopic evaluation of the staining fitted with a 4 group classification. Ninety-one samples (...

journal_title：International journal of oncology

authors： Lesec G,Richardcoulet E,Collet J,Demaublanc M,Merle S,Salmon R,Remvikos Y

更新日期：1997-04-01 00:00:00

abstract：:Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at...

journal_title：International journal of oncology

authors： Kisu I,Banno K,Kobayashi Y,Ono A,Masuda K,Ueki A,Nomura H,Hirasawa A,Abe T,Kouyama K,Susumu N,Aoki D

更新日期：2011-11-01 00:00:00

abstract：:The primary form of therapy for prostate cancer is androgen ablation resulting in apoptosis and expression of apoptotic genes (i.e. par-4). Prostate cancer cells that survive androgen ablation therapy express pro-survival genes (i.e. bcl-2) permitting these androgen independent (AI) cells to overcome apoptotic signals...

journal_title：International journal of oncology

authors： Fraizer G,Leahy R,Priyadarshini S,Graham K,Delacerda J,Diaz M

更新日期：2004-03-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety of substrates; thus a...

journal_title：International journal of oncology

authors： Vafa A,Zhang Y,Sikes RA,Marengo SR

更新日期：1998-12-01 00:00:00

abstract：:KRAS‑mutant colorectal cancer (CRC) is a highly malignant cancer with a poor prognosis, however specific therapies targeting KRAS mutations do not yet exist. Anti‑epidermal growth factor receptor (EGFR) agents, including cetuximab and panitumumab, are effective for the treatment of certain patients with CRC. However, ...

journal_title：International journal of oncology

authors： Koyama M,Kitazawa M,Nakamura S,Matsumura T,Miyazaki S,Miyagawa Y,Muranaka F,Tokumaru S,Okumura M,Yamamoto Y,Ehara T,Hondo N,Takahata S,Takeoka M,Miyagawa SI,Soejima Y

更新日期：2020-11-01 00:00:00

abstract：:We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration o...

journal_title：International journal of oncology

authors： Yatsunami J,Aoki S,Fukuno Y,Kikuchi Y,Kawashima M,Hayashi SI

更新日期：2000-12-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making ...

journal_title：International journal of oncology

authors： Park JG,Yuan Y

更新日期：1998-04-01 00:00:00