Magnolol inhibits angiogenesis by regulating ROS-mediated apoptosis and the PI3K/AKT/mTOR signaling pathway in mES/EB-derived endothelial-like cells.

abstract：:Most malignant tumors have a defect in the Rb pathway that allows them to proliferate autonomously, unrestricted by the availability of mitogens and growth factors. This defect preconditions tumor cells to be less sensitive to inhibitors of growth factor receptors and/or signal transduction pathways that arrest normal...

journal_title：International journal of oncology

authors： Du L,Smolewski P,Bedner E,Traganos F,Darzynkiewicz Z

更新日期：2001-10-01 00:00:00

abstract：:Phosphorylation of histone H2AX (gammaH2AX) is a sensitive marker of DNA damage, particularly induction of DNA double-strand breaks. Using multiparameter cytometry we explored the effects of doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types of endometrioid adenocarcinoma cell lines (HEC-1A, H...

journal_title：International journal of oncology

authors： Ikeda M,Kurose A,Takatori E,Sugiyama T,Traganos F,Darzynkiewicz Z,Sawai T

更新日期：2010-05-01 00:00:00

abstract：:From January 1992 to December 1995, 129 patients with previously untreated non-Hodgkin's lymphoma were randomised in a phase III multicenter trial to receive CEOP-B/VIMB or ProMACE-CytaBOM. Eligibility criteria included intermediate or high grade lymphoma (follicular large cell, diffuse small cleaved-cell, diffuse mix...

journal_title：International journal of oncology

authors： Lorusso V,Palmieri G,Bianco AR,Abate G,Catalano G,De Vita F,Dammacco F,Lauta VM,Lucarelli G,Polimeno G,Mantovani G,D'Aprile M,Marzullo F,De Lena M

更新日期：2000-01-01 00:00:00

abstract：:The cytosine analogue 5'-azacytidine (5'-aza) induces DNA hypomethylation by inhibiting DNA methyltransferase. In clinical trials, 5'-aza is widely used in epigenetic anticancer treatments. Accumulated evidence shows that cyclooxygenase-2 (COX-2) is overexpressed in various cancers, indicating that it may play a criti...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2015-10-01 00:00:00

abstract：:Intracellular antigens are presented to CD8+ T cells through major histocompatibility complex (MHC) class I molecule. For stable MHC class I expression, several molecules as well as the MHC molecule itself have to express simultaneously and function well. To determine a gene associated with MHC class I surface express...

journal_title：International journal of oncology

authors： Kang JK,Yoon SJ,Kim NK,Heo DS

更新日期：2000-06-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against several human cancer cell lines. In the present study, we investigated further possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured...

journal_title：International journal of oncology

authors： Park C,Jung JH,Kim ND,Choi YH

更新日期：2007-01-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, is very closely associated with telomerase activity. Telomerase has been implicated in cellular immortalization and carcinogenesis. In situ detection of hTERT will aid in determining the localization of telomerase-positive cells. The ...

journal_title：International journal of oncology

authors： Kammori M,Izumiyama N,Hashimoto M,Nakamura K,Okano T,Kurabayashi R,Naoki H,Honma N,Ogawa T,Kaminishi M,Takubo K

更新日期：2005-11-01 00:00:00

abstract：:The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC a...

journal_title：International journal of oncology

authors： Nowak A,Dziegiel P

更新日期：2018-08-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...

journal_title：International journal of oncology

authors： Hossain MA,Kim DH,Jang JY,Kang YJ,Yoon JH,Moon JO,Chung HY,Kim GY,Choi YH,Copple BL,Kim ND

更新日期：2012-04-01 00:00:00

abstract：:It has been reported that MUC-1 molecules devoid of the tandem repeat region (MUC-1/Y) are detected preferentially in carcinoma cells and are associated with their progression. However, its clinical significance is still unknown. We constructed a mouse colon adenocarcinoma cell line (MC-38) transduced with either MUC-...

journal_title：International journal of oncology

authors： Akagi J,Takai E,Tamori Y,Nakagawa K,Ogawa M

更新日期：2001-05-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a member of the sirtuin deacetylases (sirtuins), which are derivatives of the yeast Silent information regulator 2 (Sir2) protein. SIR2 and its mammalian derivatives play a central role in epigenetic gene silencing, recombination, metabolism, cell differentiation and in the regulation of aging. In...

journal_title：International journal of oncology

authors： Mahlknecht U,Ho AD,Voelter-Mahlknecht S

更新日期：2006-02-01 00:00:00

abstract：:CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baical...

journal_title：International journal of oncology

authors： Ohkoshi E,Umemura N

更新日期：2017-02-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:Chemo- and radiotherapy induce apoptosis in tumours and surrounding tissues. In a search for robust and reliable apoptosis markers, we have evaluated immunostaining patterns of gammaH2AX and cleaved PARP-1 in paraffin-embedded cellular spheroids. Breast cancer BT474 cells were grown as cell spheroids to diameters of 7...

journal_title：International journal of oncology

authors： Qvarnström OF,Simonsson M,Eriksson V,Turesson I,Carlsson J

更新日期：2009-07-01 00:00:00

abstract：:The p53-induced wig-1 gene encodes an unusual nuclear zinc finger protein with high sequence similarity between human, rat and mouse. Wig-1 belongs to a group of proteins with widely spaced zinc fingers that bind double stranded (ds) RNA. We show here that wig-1 is present in Gallus gallus (chicken), Silurana tropical...

journal_title：International journal of oncology

authors： Hellborg F,Wiman KG

更新日期：2004-06-01 00:00:00

abstract：:The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...

journal_title：International journal of oncology

authors： Joly B,Lecureur V,Puozzo C,Guillouzo A,Fardel O

更新日期：1996-11-01 00:00:00

abstract：:Ligands of the EGF/Heregulin family control the growth of epithelial cells by binding to receptors of the erbB family. By searching a large database of cDNA sequences at Human Genome Sciences Inc. we have identified a new encoded protein sequence containing all the conserved elements of the EGF/Heregulin family. The s...

journal_title：International journal of oncology

authors： Hijazi MM,Young PE,Dougherty MK,Bressette DS,Cao TT,Pierce JH,Wong LM,Alimandi M,King CR

更新日期：1998-11-01 00:00:00

abstract：:According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...

journal_title：International journal of oncology

authors： Furihata M,Sonobe H,Ohtsuki Y

更新日期：1995-06-01 00:00:00

abstract：:Among many risk factors of breast cancer, estrogens and non-estrogenic endocrine disruptors are considered to play critical roles in human breast carcinogenesis. Zeranol (Z) is a non-steroidal agent with potent estrogenic activity and has been widely used as an FDA approved beef growth promoter in the US. Recently, co...

journal_title：International journal of oncology

authors： Ye W,Xu P,Zhong S,Jen R,Threlfall WR,Frasure CV,Feng E,Li H,Lin SH,Liu JY,Lin YC

更新日期：2011-04-01 00:00:00

abstract：:Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...

journal_title：International journal of oncology

authors： Huang Z,McWilliams A,Lam S,English J,McLean DI,Lui H,Zeng H

更新日期：2003-09-01 00:00:00

abstract：:Cowden's disease (CD) is an autosomal dominant disorder which confers a high susceptibility to diverse benign and malignant tumors. The PTEN (phosphatase and tensin homologue deleted in chromosome ten) gene has been identified as a tumor suppressor gene responsible for cancers of the endometrium, ovary, prostate, and ...

journal_title：International journal of oncology

authors： Kato N,Kimura K,Sugawara H,Aoyagi S,Ikeda T,Horii A

更新日期：2001-05-01 00:00:00

abstract：:Over the past few decades, there has been a tremendous increase in cancer biology data and treatment. Cancer research has opened exciting new areas of cellular and molecular biology. Month by month, new genes which regulate the carcinogenesis process are being discovered. The result is an incredible knowledge of cance...

journal_title：International journal of oncology

authors： Kanduc D,Bannasch P,Farber E

更新日期：1999-12-01 00:00:00

abstract：:Sodium metaarsenite (NaAs2O3: code name KML001) is an orally bioavailable arsenic compound with potential anti-cancer activity. However, the effect of KML001 has not been studied in acute myeloid leukemia (AML). We investigated the anti-leukemic effect of KML001 in AML, and determined the mode of action of KML001. KML...

journal_title：International journal of oncology

authors： Yoon JS,Kim ES,Park BB,Choi JH,Won YW,Kim S,Lee YY

更新日期：2015-05-01 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis protein (IAP) family and is frequently expressed in cancers, including meningiomas and gliomas. Survivin may be associated with tumor progression and poor prognosis of patients with brain tumors. Using ELISA and immunoblot analysis we asked whether survivin is capable...

journal_title：International journal of oncology

authors： Söling A,Plugge EM,Schmitz M,Weigle B,Jacob R,Illert J,Holzhausen HJ,Rainov NG

更新日期：2007-01-01 00:00:00

abstract：:The intensity of post-treatment melanoma patient follow-up varies widely among physicians. We investigated whether physician age accounts for the observed variation in surveillance intensity among plastic surgeons. A custom-designed questionnaire was mailed to USA and non-USA surgeons, all of whom were members of the ...

journal_title：International journal of oncology

authors： Margenthaler JA,Virgo KS,Johnson DY,Sugarbaker EM,Handler BS,Johnson FE

更新日期：2001-07-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:Recent studies have reported that chemically synthesized small activating RNA (saRNA) targeting the promoter regions of a gene can activate its expression in different cell lines. This technique can be a powerful therapeutic method for diseases caused by complete inactivation or reduced expression of specific genes. E...

journal_title：International journal of oncology

authors： Wu Z,Li Y,Li Z,Liu Z,Qin Z,Li X,Ye Y,Bu L,Lin B,Wang Z,Jia G,Chen G

更新日期：2016-10-01 00:00:00

abstract：:CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...

journal_title：International journal of oncology

authors： Jing F,Kim HJ,Kim CH,Kim YJ,Lee JH,Kim HR

更新日期：2015-04-01 00:00:00

abstract：:Meningiomas are the most commonly occurring tumors of the central nervous system including the brain and spinal cord. Malignant meningiomas are highly aggressive and frequently recur after surgical resection of the tumor. Our previous studies have reported that urokinase plasminogen activator receptor (uPAR) and matri...

journal_title：International journal of oncology

authors： Tummalapalli P,Gondi CS,Dinh DH,Gujrati M,Rao JS

更新日期：2007-07-01 00:00:00

abstract：:Dendritic cells play a major role in cellular immunity. The crucial steps of antigen presentation and processing by DCs may be limiting factors for adoptive cellular immunotherapy. Here, we investigated whether hyperthermia of human hepatocellular carcinoma (HCC) cells induces enhanced cytotoxic cellular immune respon...

journal_title：International journal of oncology

authors： Schueller G,Stift A,Friedl J,Dubsky P,Bachleitner-Hofmann T,Benkoe T,Jakesz R,Gnant M

更新日期：2003-06-01 00:00:00