Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model.

abstract：:Loss of E-cadherin and catenin expression may be associated with distant and lymph node metastases in breast cancer. Heterogeneity of E-cadherin expression is associated with poor prognosis, suggesting that E-cadherin and catenins may serve as useful prognostic markers for invasive breast carcinoma. Reduction or loss ...

journal_title：International journal of oncology

authors： Yoshida R,Kimura N,Harada Y,Ohuchi N

更新日期：2001-03-01 00:00:00

abstract：:Aurora-A is involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and regards to an oncogene. Aurora-A is also known to bind to several other proteins affecting its up-regulation or down-regulation and localization. However, how these different binding signals work together to regulate Auro...

journal_title：International journal of oncology

authors： Lieu AS,Cheng TS,Chou CH,Wu CH,Hsu CY,Huang CY,Chang LK,Loh JK,Chang CS,Hsu CM,Howng SL,Hong YR

更新日期：2010-08-01 00:00:00

abstract：:To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% o...

journal_title：International journal of oncology

authors： Molendini L,Benassi MS,Magagnoli G,Merli M,Sollazzo MR,Ragazzini P,Gamberi G,Ferrari C,Balladelli A,Bacchini P,Picci P

更新日期：1998-05-01 00:00:00

abstract：:A promising family of anticancer agents, the camptothecins, is noted for their ability to induce apoptosis specifically in malignant cells. However, a major obstacle for successful cancer treatment by these and other chemotherapeutic agents is the intrinsic or acquired resistance to drug treatment. Resistance to 9NC6,...

journal_title：International journal of oncology

authors： Chatterjee D,Goldman M,Braastad CD,Darnowski J,Wyche JH,Pantazis P,Goodglick L

更新日期：2004-08-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00

abstract：:Ewing's sarcoma (ES) is a rare tumor that is more frequent in pediatric and adolescent age groups. In the past few decades, long-term survival in affected patients has improved due to the success of multimodal therapy. However, long-term survival is inevitably restricted by the late side-effects of chemotherapy. Besid...

journal_title：International journal of oncology

authors： Ye C,Yu X,Zeng J,Dai M,Zhang B

更新日期：2017-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy. The hedgehog-EMT pathway is preferentially activated in diffuse-type gastric cancer (GC) compared with intestinal-type GC; however, histological typing is currently the only method for distinguishing these two major types of GC. We compared t...

journal_title：International journal of oncology

authors： Tanabe S,Aoyagi K,Yokozaki H,Sasaki H

更新日期：2014-06-01 00:00:00

abstract：:Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...

journal_title：International journal of oncology

authors： Jung KH,Ryu YL,Lee HS,Lee H,Son MK,Yan HH,Hong SW,Ryu JK,Hong S,Suh JK,Hong SS

更新日期：2013-06-01 00:00:00

abstract：:We assessed Stanniocalcin-1 (STC-1) mRNA expression in human normal tissues, various types of human cancer cell lines, and cancer tissues obtained during surgery. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay developed to detect STC-1 mRNA, the transcripts were detected in 20 out of 21 cancer ...

journal_title：International journal of oncology

authors： Fujiwara Y,Sugita Y,Nakamori S,Miyamoto A,Shiozaki K,Nagano H,Sakon M,Monden M

更新日期：2000-04-01 00:00:00

abstract：:The human ovarian cancer cell line OV-MZ-19, established from a patient with cystadenocarcinoma of the ovary, expressing thrombomodulin (TM), a cell surface receptor for the serine protease thrombin, interacts with monoclonal and polyclonal antibodies having different specificity for TM. These antibodies detect TM ant...

journal_title：International journal of oncology

authors： Wilhelm S,Schmitt M,Parkinson J,Kuhn W,Graeff H,Wilhelm OG

更新日期：1998-10-01 00:00:00

abstract：:Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been frequently administered in colon cancer patients, low response rates to these single drug therapies were reported. It is therefore imperative to search for new targeted combination therapies t...

journal_title：International journal of oncology

authors： Ling LU,Lin H,Tan KB,Chiu GN

更新日期：2009-12-01 00:00:00

abstract：:Gene amplification occurs frequently in human glioblastomas. We report the amplification and expression analysis of glioma amplified sequence 64 (GAS64) which was recently identified by microdissection mediated cDNA capture from the amplicon at 12q13-15. Herein we analyzed primary tumor tissues for amplification frequ...

journal_title：International journal of oncology

authors： Fischer U,Schütz N,Hemmer D,Meese E

更新日期：2002-01-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:The interactions between cells and the extracellular matrix (EM) have important effects on tumor invasion and metastasis. Osteosarcoma (OS) is a highly metastatic tumor, secondary lesions occurring early in the natural history of the disease. Despite the clinical relevance of disseminated disease in this neoplasia, th...

journal_title：International journal of oncology

authors： Scotlandi K,Serra M,Manara M,Nanni P,Nicoletti G,Landuzzi L,Maurici D,Baldini N

更新日期：1993-11-01 00:00:00

abstract：:The effect of reduced glutathione (GSH) and ethanol on aflatoxin B1 (AFB1)-induced DNA single strand breaks was studied in primary cultured hepatocytes. Buthionine sulfoximine (BSO) which decreased intracellular GSH to 13% of those of the control levels increased DNA fragmentation of AFB1-treated hepatocytes by over 1...

journal_title：International journal of oncology

authors： Tsutsumi N,Miyazaki K

更新日期：1994-01-01 00:00:00

abstract：:As epidemiological data suggest ultraviolet (UV) radiation to be the major environmental factor for the development of melanoma, we screened this malignancy for UV-specific C right curved arrow T and CC right curved arrow TT DNA mutations as described in squamous and basal cell carcinomas of the skin. Mitochondrial (m...

journal_title：International journal of oncology

authors： Deichmann M,Kahle B,Benner A,Thome M,Helmke B,Näher H

更新日期：2004-01-01 00:00:00

abstract：:A relevant animal model is critical for investigating the pathogenic mechanisms underlying hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC). Mice are not naturally infected by HBV, presumably due to the lack of HBV receptors on mouse hepatocytes. To bypass this entry step of HBV infection, we report gene...

journal_title：International journal of oncology

authors： Huang YH,Fang CC,Tsuneyama K,Chou HY,Pan WY,Shih YM,Wu PY,Chen Y,Leung PS,Gershwin ME,Tao MH

更新日期：2011-12-01 00:00:00

abstract：:Endoscopic examination with iodine staining has led to the easy detection of multiple superficial esophageal carcinoma (MSEC). The purpose of this study was to better understand the characteristics of MSEC. Of 49 patients with multiple esophageal carcinomas, 19 had superficial carcinoma. Multiple esophageal carcinomas...

journal_title：International journal of oncology

authors： Fujii T,Yamana H,Fujita H,Sueyoshi S,Nakashima A,Hayashi I,Nishi M,Kato S,Shirouzu K,Morimatsu M

更新日期：1998-02-01 00:00:00

abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

journal_title：International journal of oncology

authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

更新日期：2007-10-01 00:00:00

abstract：:Patients with pancreatic cancer frequently demonstrate symptoms such as weight-loss and muscle wasting and have clinical evidence of a systemic inflammatory response. Such effects may be mediated by pro-inflammatory cytokines derived from tumor cells. The production of interleukin-6 and -8 by pancreatic cancer cell li...

journal_title：International journal of oncology

authors： Wigmore SJ,Fearon KC,Sangster K,Maingay JP,Garden OJ,Ross JA

更新日期：2002-10-01 00:00:00

abstract：:Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...

journal_title：International journal of oncology

authors： Tait L,Dawson P,Wolman S,Galea K,Miller F

更新日期：1996-08-01 00:00:00

abstract：:Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...

journal_title：International journal of oncology

authors： Baillargeon J,Rose DP

更新日期：2006-03-01 00:00:00

abstract：:The support mechanisms that are involved in lymph-node metastasis of oral squamous cell carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. In this study, we examined...

journal_title：International journal of oncology

authors： Ishikawa T,Nakashiro K,Hara S,Klosek SK,Li C,Shintani S,Hamakawa H

更新日期：2006-01-01 00:00:00

abstract：:A multi-kinase inhibitor, sorafenib, was recently approved and is currently recommended for the treatment of advanced hepatocellular carcinoma (HCC). However, HCC treatment outcomes are still poor and necessitate improvement. Therefore, we investigated the influence of sorafenib in ...

journal_title：International journal of oncology

authors： Nojiri K,Sugimoto K,Shiraki K,Tameda M,Inagaki Y,Ogura S,Kasai C,Kusagawa S,Yoneda M,Yamamoto N,Takei Y,Nobori T,Ito M

更新日期：2013-01-01 00:00:00

abstract：:Although radiation therapy is a powerful anticancer modality, radiation- induced stress response and gene expression with adaptive resistance may severely compromise the effectiveness of radiation. The function of rotundic acid (RA) on inducing apoptosis in the human breast cancer cell line MCF-7 has been investigated...

journal_title：International journal of oncology

authors： Wang ZF,Sun WY,Yu DH,Zhao Y,Xu HM,He YF,Li HJ

更新日期：2018-11-01 00:00:00

abstract：:Clinicopathological assessment of the functional relationship between the HER2 oncogene and tumor-associated fatty acid synthase (FASN) is largely precluded because immunohistochemical and/or mRNA studies should be performed in biopsies from breast cancer patients. We here sought to determine whether serum FASN (sFASN...

journal_title：International journal of oncology

authors： Vazquez-Martin A,Fernandez-Real JM,Oliveras-Ferraros C,Navarrete JM,Martin-Castillo B,Del Barco S,Brunet J,Menendez JA

更新日期：2009-12-01 00:00:00

abstract：:After the publication of the article, the authors noted that they had made the following errors. In Fig. 5B, total PDK1 is incorrect in the published paper. The corrected version of Fig. 5B is shown below. Also in Fig. 6B, the DMSO-treated group and the brassinin (400 µM)-treated group are incorrect, and the corrected...

journal_title：International journal of oncology

authors： Izutani Y,Yogosawa S,Sowa Y,Sakai T

更新日期：2016-03-01 00:00:00

abstract：:An overview of the current mechanisms identified as associated with the expression of multidrug resistance is provided. The clinical relevance of multidrug resistance associated with the overexpression of the three major drug resistance-associated proteins namely, P-glycoprotein, MRP and/or LRP, is discussed. Alternat...

journal_title：International journal of oncology

authors： Hill B

更新日期：1996-08-01 00:00:00

abstract：:The aim of this study was to examine the level and basic characteristics of cell‑derived microparticles (MPs) in the cyst fluids of odontogenic keratocysts (OKCs). For this purpose, MPs from the cyst fluids (CFMPs) of OKCs were purified by a classic differential centrifugation method and characterized by a transmissio...

journal_title：International journal of oncology

authors： Man QW,Zhong WQ,Ren JG,Liu JY,Zheng YY,Li RF,Nyimi BF,Chen G,Zhao YF,Liu B

更新日期：2018-06-01 00:00:00

abstract：:Regulation of cytoplasmic p21CIP/WAF1 (p21) is of great clinical significance in molecular oncology due to its identification as an antiapoptotic factor, a poor survival predictor as well as a drug-resistance inducer. A retrospective study of the immunohistochemical (IHC) profiles of 128 human primary breast cancers s...

journal_title：International journal of oncology

authors： Ping B,He X,Xia W,Lee DF,Wei Y,Yu D,Mills G,Shi D,Hung MC

更新日期：2006-11-01 00:00:00