Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.

abstract：:An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in...

journal_title：International journal of oncology

authors： Hwang KA,Kang NH,Yi BR,Lee HR,Park MA,Choi KC

更新日期：2013-02-01 00:00:00

abstract：:Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets for metastatic melanoma. A library of 160 well-characterised and potent protein kinase inhibitors was screened in the BRAF muta...

journal_title：International journal of oncology

authors： Mahgoub T,Eustace AJ,Collins DM,Walsh N,O'Donovan N,Crown J

更新日期：2015-09-01 00:00:00

abstract：:Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...

journal_title：International journal of oncology

authors： Nowak A,Grzegrzółka J,Kmiecik A,Piotrowska A,Matkowski R,Dzięgiel P

更新日期：2018-02-01 00:00:00

abstract：:We investigated three clonally related human keratinocyte cell lines of different biological behaviour, HaCaT (non-tumorigenic), A5 (benign, tumorigenic) and II-4RT (malignant, tumorigenic), with regard to the cell-associated localization of the major MMPs -1, -2, -3, -9, -10 and -11. These observations were correlate...

journal_title：International journal of oncology

authors： Bachmeier BE,Nerlich AG

更新日期：2002-03-01 00:00:00

abstract：:The neuroepithelioma cell line CHP100 expresses low but detectable amounts of N-myc protein together with large amounts of c-myc protein. We have recently demonstrated that antisense inhibition of N-myc expression in CHP100 cells leads to decreased in vitro growth and alterations in cellular morphology without affecti...

journal_title：International journal of oncology

authors： Rosolen A,Frascella E,Toretsky J,Neckers L

更新日期：1995-01-01 00:00:00

abstract：:Specific RE protein species modulated by autocrine TGF alpha are unknown. HCT116 cells transfected with TGF alpha antisense expression vector were compared with control HCT116 NEO for mitogenesis and modulation of high MW (130, 120 kD) and low MW (116, 110, 105 kD) RE species. Nutrients alone (N) induced maximal mitog...

journal_title：International journal of oncology

authors： Dobre C,Ziober B,Humphrey L,Brattain M

更新日期：1996-06-01 00:00:00

abstract：:Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...

journal_title：International journal of oncology

authors： Choi EO,Park C,Hwang HJ,Hong SH,Kim GY,Cho EJ,Kim WJ,Choi YH

更新日期：2016-09-01 00:00:00

abstract：:We examined the effect of estrogens on mitogen-activated protein kinase (MAPK) in EPN cells, a line of epithelial cells derived from human normal prostate. 17beta-estradiol (E2) caused a rapid and transient activation of MAPK (ERK1/2) within 5 min. This effect was counteracted by the anti-estrogen ICI 182-780 and by M...

journal_title：International journal of oncology

authors： Chieffi P,Kisslinger A,Sinisi AA,Abbondanza C,Tramontano D

更新日期：2003-09-01 00:00:00

abstract：:Tumor necrosis factor‑associated apoptosis‑inducing ligand (TRAIL) is considered to be a potential therapeutic target for various types of cancer. However, colon cancer is difficult to treat due to its resistance to TRAIL. Therefore, various trials have been conducted to overcome TRAIL resistance in colon cancer. The ...

journal_title：International journal of oncology

authors： Kim B,Seo JH,Lee KY,Park B

更新日期：2020-03-01 00:00:00

abstract：:Overexpression of inducible nitric oxide synthase (iNOS) and the resultant overproduction of NO has been implicated in neuronal inflammatory diseases. Leptomycin B (LMB), a metabolite of Streptomyces, has been identified as a specific inhibitor of CRM1 nuclear export receptor. In this study, we evaluated the effect of...

journal_title：International journal of oncology

authors： Jang BC,Sung SH,Park JG,Park JW,Suh MH,Choi IH,Yoshida M,Yoo SK,Suh SI

更新日期：2006-12-01 00:00:00

abstract：:The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in the progression of prostate cancer. In this study, we examined whether the TGF-β signaling pathway is associated...

journal_title：International journal of oncology

authors： Lee HR,Hwang KA,Choi KC

更新日期：2014-08-01 00:00:00

abstract：:The prognostic significance of Ki 67/MIB1 immunohistochemical assays (ICAs) was investigated in optimal technical conditions in 139 breast carcinomas. Automated ICAs (immunoperoxidase/Ventana device) was performed on frozen sections. Immunoprecipitates were quantified by computerized analysis (SAMBA) of digitized micr...

journal_title：International journal of oncology

authors： Charpin C,Garcia S,Bouvier C,Devictor B,Andra L,Lavaut M,Allasia C,Bonnier P

更新日期：1996-08-01 00:00:00

abstract：:No population-based study has been conducted on the relationship between chemotherapy and the risk of cognitive impairments in patients with colorectal cancer. This study aimed to determine this association in a large population-based cohort of patients. We studied 72,374 men and women who were diagnosed with stages I...

journal_title：International journal of oncology

authors： Du XL,Cai Y,Symanski E

更新日期：2013-06-01 00:00:00

abstract：:The impacts of post‑operative abdominal infectious complications increase hematogenous distant metastasis and result in poor long‑term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is a...

journal_title：International journal of oncology

authors： Okazaki M,Yamaguchi T,Tajima H,Fushida S,Ohta T

更新日期：2020-10-01 00:00:00

abstract：:Five retinoblastoma tumours from patients treated in the King Khaled Eye Specialist Hospital in Riyadh were analysed for mutations in the RB1 gene using single strand conformation polymorphism analysis and mutations were found in all of them. In one tumour the mutation in exon 11 was homozygous demonstrating the role ...

journal_title：International journal of oncology

authors： Su G,Senft S,Cowell J

更新日期：1995-03-01 00:00:00

abstract：:B7-H4 is a transmembrane protein which is a member of the B7 superfamily. It is overexpressed in various types of cancer, including gastric cancer. However, the effects of B7-H4 on the tumorigenicity of gastric cancer and the underlying mechanisms have not yet been fully explored. Thus, the aim of this study was to ex...

journal_title：International journal of oncology

authors： Zhou D,Zhou Y,Li C,Yang L

更新日期：2018-04-01 00:00:00

abstract：:We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration o...

journal_title：International journal of oncology

authors： Yatsunami J,Aoki S,Fukuno Y,Kikuchi Y,Kawashima M,Hayashi SI

更新日期：2000-12-01 00:00:00

abstract：:Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

journal_title：International journal of oncology

authors： Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

更新日期：2005-02-01 00:00:00

abstract：:The effect of reduced glutathione (GSH) and ethanol on aflatoxin B1 (AFB1)-induced DNA single strand breaks was studied in primary cultured hepatocytes. Buthionine sulfoximine (BSO) which decreased intracellular GSH to 13% of those of the control levels increased DNA fragmentation of AFB1-treated hepatocytes by over 1...

journal_title：International journal of oncology

authors： Tsutsumi N,Miyazaki K

更新日期：1994-01-01 00:00:00

abstract：:Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...

journal_title：International journal of oncology

authors： Umene K,Yanokura M,Banno K,Irie H,Adachi M,Iida M,Nakamura K,Nogami Y,Masuda K,Kobayashi Y,Tominaga E,Aoki D

更新日期：2015-04-01 00:00:00

abstract：:We investigated the relationship between cell growth and differentiation and COX-2 expression in oral squamous cell carcinoma (SCC) in vitro and in vivo. Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and in...

journal_title：International journal of oncology

authors： Kuroda J,Urade M,Kishimoto H,Noguchi K,Hashitani S,Sakurai K,Nishimura N,Hashimoto-Tamaoki T

更新日期：2005-02-01 00:00:00

abstract：:Established human breast cancer cell lines are widely used as experimental models in breast cancer research. While these cell lines and their variants share many phenotypic characteristics with human breast tumors, the extent to which they reflect the underlying molecular biology of breast cancer remains controversial...

journal_title：International journal of oncology

authors： Zhu Y,Wang A,Liu MC,Zwart A,Lee RY,Gallagher A,Wang Y,Miller WR,Dixon JM,Clarke R

更新日期：2006-12-01 00:00:00

abstract：:Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...

journal_title：International journal of oncology

authors： Naujocks G,Schmitz A,Schramm J,Wiestler O,Schirrmacher V

更新日期：1995-04-01 00:00:00

abstract：:All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein ...

journal_title：International journal of oncology

authors： Nutthasirikul N,Limpaiboon T,Leelayuwat C,Patrakitkomjorn S,Jearanaikoon P

更新日期：2013-04-01 00:00:00

abstract：:We examined the effects of suppressing multidrug resistance-associated protein (MRP) and multidrug resistance 1 (MDR1) gene expression in HCT-8DDP human colon cancer cell lines, which showed both cisplatin and multidrug resistance. Hammerhead ribozymes, designed to cleave MRP mRNA (anti-MRP Rz) and MDR1 mRNA (anti-MDR...

journal_title：International journal of oncology

authors： Nagata J,Kijima H,Hatanaka H,Asai S,Miyachi H,Abe Y,Yamazaki H,Nakamura M,Watanabe N,Mine T,Kondo T,Scanlon KJ,Ueyama Y

更新日期：2002-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...

journal_title：International journal of oncology

authors： Collet N,Théoleyre S,Rageul J,Mottier S,Jouan F,Rioux-Leclercq N,Fergelot P,Patard JJ,Masson D,Denis MG

更新日期：2011-03-01 00:00:00

abstract：:Selenium is considered to be one of the most promising micronutrients for cancer prevention and therapy, based on evidence from epidemiological studies, laboratory-based research and clinical trial intervention. There are ample reports of selenium methionine and sodium selenite's ability to induce apoptosis in various...

journal_title：International journal of oncology

authors： Rooprai HK,Kyriazis I,Nuttall RK,Edwards DR,Zicha D,Aubyn D,Davies D,Gullan R,Pilkington GJ

更新日期：2007-05-01 00:00:00

abstract：:NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...

journal_title：International journal of oncology

authors： Maruyama K,Tsukada T,Ohkura N,Bandoh S,Hosono T,Yamaguchi K

更新日期：1998-06-01 00:00:00

abstract：:Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulation of hTERT. All-trans retinoic acid (ATRA) induces differentiation in...

journal_title：International journal of oncology

authors： Love WK,Berletch JB,Andrews LG,Tollefsbol TO

更新日期：2008-03-01 00:00:00

abstract：:Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...

journal_title：International journal of oncology

authors： Zhang MH,Hu YD,Xu Y,Xiao Y,Luo Y,Song ZC,Zhou J

更新日期：2013-04-01 00:00:00