PPARγ is functionally expressed in clear cell renal cell carcinoma.

abstract：:Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR pathway inhibitors on human neuroblastoma cell survival were studied in vitro. We have recently shown on IMR-32, CHP‑134, and LA-N-1 neuroblastoma cells that targeting GD2 with the mAb decr...

journal_title：International journal of oncology

authors： Durbas M,Horwacik I,Boratyn E,Kamycka E,Rokita H

更新日期：2015-09-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00

abstract：:An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

journal_title：International journal of oncology

authors： Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

更新日期：2011-07-01 00:00:00

abstract：:The purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (IAPs), their inhibitor, Smac, and the focal adhesion kinase (FAK) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, NCCIT. We demonstrated that specifically in laminin-adheren...

journal_title：International journal of oncology

authors： Andjilani M,Droz JP,Benahmed M,Tabone E

更新日期：2006-02-01 00:00:00

abstract：:Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The re...

journal_title：International journal of oncology

authors： Zhang Y,Ying X,Han S,Wang J,Zhou X,Bai E,Zhang J,Zhu Q

更新日期：2013-01-01 00:00:00

abstract：:Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases re...

journal_title：International journal of oncology

authors： Dong Z,Yang J,Li L,Tan L,Shi P,Zhang J,Zhong X,Ge L,Wu Z,Cui H

更新日期：2020-03-01 00:00:00

abstract：:Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...

journal_title：International journal of oncology

authors： Devor EJ,Gonzalez-Bosquet J,Thiel KW,Leslie KK

更新日期：2020-12-01 00:00:00

abstract：:In an attempt to isolate potential molecular targets for diagnosis, treatment and/or prevention of colorectal cancer (CRC), we have been analyzing expression profiles of clinical samples from CRC patients using genome-wide cDNA microarray. Among the genes up-regulated frequently in colorectal tumors, we here focused o...

journal_title：International journal of oncology

authors： Shimokawa T,Matsushima S,Tsunoda T,Tahara H,Nakamura Y,Furukawa Y

更新日期：2006-08-01 00:00:00

abstract：:Many clinical studies highlight the dichotomous role of PRDXs in human cancers, where they can exhibit strong tumor-suppressive or tumor-promoting functions. Recent evidence suggests that lower expression of PRDXs correlates with cancer progression in colorectal cancer (CRC) or in esophageal squamous carcinoma. In the...

journal_title：International journal of oncology

authors： Nicolussi A,D'Inzeo S,Mincione G,Buffone A,Di Marcantonio MC,Cotellese R,Cichella A,Capalbo C,Di Gioia C,Nardi F,Giannini G,Coppa A

更新日期：2014-02-01 00:00:00

abstract：:The perineural invasion (PNI) of malignant tumors is a form of tumor progression in which cancer cells encroach along nerves. PNI hinders curative resection. Residual tumor cells in or around nerves can bring about local recurrence, infiltration and metastasis. This behavior is usually associated with a poor clinical ...

journal_title：International journal of oncology

authors： Zhang M,Zhu ZL,Gao XL,Wu JS,Liang XH,Tang YL

更新日期：2018-05-01 00:00:00

abstract：:Three novel isoforms of the neurofibromatosis 2 (NF2) gene transcripts generated from alternative splicing were identified from normal human brain, schwannoma and glioma tissues. The 3 novel transcripts lack exon 2, exons 2 and 3, exons 2-4, respectively. Recombinant isoform proteins encoded by those new transcripts h...

journal_title：International journal of oncology

authors： Nishi T,Takeshima H,Hamada K,Yoshizato K,Koga H,Sato K,Yamamoto K,Kitamura I,Kochi M,Kuratsu J,Saya H,Ushio Y

更新日期：1997-05-01 00:00:00

abstract：:Chlorophyllin (CHL) is the sodium-copper salts of chlorophyll derivatives. In this study, the CHL was derived from a traditional Chinese medicine, the Bombyx mori excreta. The CHL, at concentrations 25-400 microg/ml, reduced the proliferation of HL-60, K-562, S-180, and MCF-7 cells by 8.2-95.7% after 72 h of incubatio...

journal_title：International journal of oncology

authors： Chiu LC,Kong CK,Ooi VE

更新日期：2003-09-01 00:00:00

abstract：:Rituximab resistance has become increasingly common in patients with diffuse large B cell lymphoma (DLBCL). However, the mechanisms involved remain unclear. In this study, we aimed to examine the effect of rituximab on interleukin (IL)-17A and to investigate the role of IL-17A in rituximab resistance and its prognosti...

journal_title：International journal of oncology

authors： Zhong W,Xu X,Zhu Z,Yang L,Du H,Xia Z,Yuan Z,Xiong H,Du Q,Wei Y,Li Q

更新日期：2018-05-01 00:00:00

abstract：:The expression of proinflammatory cytokines in various malignant neoplasms is widely considered to represent the host immune response to tumor development. The role of interferon (IFN)γ in head and neck squamous cell carcinoma, and its association with endoplasmic reticulum (ER) stress pathways, remains a subject of o...

journal_title：International journal of oncology

authors： Gkouveris I,Nikitakis NG,Aseervatham J,Ogbureke KUE

更新日期：2018-12-01 00:00:00

abstract：:Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying development of multidrug-resistance in NB we established two neuroblastoma cell sublines resistant to vincristine (UKF-NB-3rVCR10) and doxorubicin (UKF-NB-3rDOX20...

journal_title：International journal of oncology

authors： Kotchetkov R,Driever PH,Cinatl J,Michaelis M,Karaskova J,Blaheta R,Squire JA,Von Deimling A,Moog J,Cinatl J Jr

更新日期：2005-10-01 00:00:00

abstract：:Telomerase activity and its subunits (hTERC, hTERT mRNA) were evaluated in ovarian tumours in relation to the expression of p53, c-Myc and estrogen receptor (ER). Furthermore, relations between telomerase activity, hTERC and hTERT with known clinicopathologic prognostic factors and survival in patients with malignant ...

journal_title：International journal of oncology

authors： Wisman GB,Hollema H,Helder MN,Knol AJ,Van der Meer GT,Krans M,De Jong S,De Vries EG,Van der Zee AG

更新日期：2003-11-01 00:00:00

abstract：:This study suggests that speckle-type POZ protein (SPOP) may be a tumor suppressor gene and its prognostic value in human glioma. Real-time quantitative RT-PCR (qRT‑PCR), western blotting, and immunohistochemical staining were used to examine SPOP expression in glioma tissues and normal brain (NB) tissues. The relatio...

journal_title：International journal of oncology

authors： Ding D,Song T,Jun W,Tan Z,Fang J

更新日期：2015-01-01 00:00:00

abstract：:Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

journal_title：International journal of oncology

authors： Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

更新日期：2007-02-01 00:00:00

abstract：:Meningiomas are the most commonly occurring intracranial tumors and account for approximately 15-20% of central nervous system tumors. Patients whose tumors recur after surgery and radiation therapy have limited therapeutic options. It has also been reported recently that radiation triggers DNA repair, cell survival a...

journal_title：International journal of oncology

authors： Gupta R,Rao Gogineni V,Nalla AK,Chetty C,Klopfenstein JD,Tsung AJ,Mohanam S,Rao JS

更新日期：2011-04-01 00:00:00

abstract：:Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS) and binds to a variety of receptors, which recently have also been detected in peripheral, non-excitable cells. New research suggests that this abundant amino acid might also be involved in the growth of tumor cells acting via novel...

journal_title：International journal of oncology

authors： Haas HS,Pfragner R,Siegl V,Ingolic E,Heintz E,Schauenstein K

更新日期：2005-09-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:Over-expression of p21Waf-1 was performed in 5 human glioma cell lines (U251MG, U87MG, T98G, NMC-G1, and KALS-1). p53 gene status was examined by PCR-SSCP and direct sequence method. The endogenous p21Waf-1 expression was evaluated by RT-PCR. Adenovirus-mediated over-expression of p21Waf-1 inhibited the proliferation ...

journal_title：International journal of oncology

authors： Terasaki M,Kato S,Sugita Y,Shigemori M,Morimatsu M

更新日期：1999-01-01 00:00:00

abstract：:Seven ovarian and one cervical human cancer cell lines were examined far their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and to...

journal_title：International journal of oncology

authors： Aluigi M,Debernardis D,Cimoli G,Ottoboni C,Parodi S,Russo P

更新日期：1995-09-01 00:00:00

abstract：:The Equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, Herba epimedium brevicornum Maxim (stem and leaves), Radix morindae officinalis (root), Fructus rosa laevigatae michx (fruit), Rubus chingii Hu (fruit), Schisandra chinensis (Turz.) Baill (fruit), Ligustrum lucidum ...

journal_title：International journal of oncology

authors： Hsieh TC,Lu X,Guo J,Xiong W,Kunicki J,Darzynkiewicz Z,Wu JM

更新日期：2002-04-01 00:00:00

abstract：:Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...

journal_title：International journal of oncology

authors： Brito AF,Abrantes AM,Teixo R,Pires AS,Ribeiro AC,Ferreira RF,Mascarenhas A,Puga T,Laranjo M,Caramelo F,Boin I,Jefferson DM,Gonçalves C,Martins R,Tavares I,Ribeiro IP,Sarmento-Ribeiro AB,Carreira IM,Souza D,Tralhão J

更新日期：2020-03-01 00:00:00

abstract：:miRNA‑223 (miR‑223) has been reported to function not only as a tumor suppressor, but also as an oncogenic microRNA (miRNA or miR) in various cancer cells. Therefore, the functional role of miR‑223 has not been elucidated to date, at least to the best of our knowledge. We previously performed the deep sequencing analy...

journal_title：International journal of oncology

authors： Sugita S,Yoshino H,Yonemori M,Miyamoto K,Matsushita R,Sakaguchi T,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2019-06-01 00:00:00

abstract：:Curcumin shows growth-inhibition against tumor cells through multi-target mechanisms. Nevertheless, the poor stability and pharmacokinetics considerably limit its clinical functions. Increased effort has been put into the chemical alteration of curcumin to find potential analogues with improved bioavailability and ant...

journal_title：International journal of oncology

authors： Pan Y,Liu G,Xiao J,Su B,Zhou F,Wei Y

更新日期：2016-05-01 00:00:00

abstract：:Oncogenic drivers of osteosarcoma remain controversial due to the complexity of the genomic background of the disease. There are limited novel therapeutic options, and the survival rate of patients with osteosarcoma has not improved in decades. Genomic instability leads to complexity in various pathways, which is pote...

journal_title：International journal of oncology

authors： Chaiyawat P,Sungngam P,Teeyakasem P,Sirikaew N,Klangjorhor J,Settakorn J,Diskul-Na-Ayudthaya P,Chokchaichamnankit D,Srisomsap C,Svasti J,Pruksakorn D

更新日期：2019-05-01 00:00:00

abstract：:Choriocarcinoma is a highly malignant trophoblastic tumor related to pregnancy that often occurs with a complete hydatidiform mole. It grows quickly and can also widely metastasize to other organs or tissues through both the venous and lymphatic systems. The transforming growth factor-β1 (TGF-β1) belongs to a growth f...

journal_title：International journal of oncology

authors： Xu Q,Tan Y,Zhang K,Li Y

更新日期：2013-10-01 00:00:00

abstract：:Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects...

journal_title：International journal of oncology

authors： Drago-Ferrante R,Santulli A,Di Fiore R,Giuliano M,Calvaruso G,Tesoriere G,Vento R

更新日期：2008-10-01 00:00:00