Tumor-necrosis-factor and DNA topoisomerase-ii inhibitors in human ovarian-cancer - potential role in chemotherapy.

abstract：:The promising benefits of cancer gene therapy have been limited by the inability to deliver therapeutic genes homogeneously throughout the tumor mass and to control gene expression within the tumor cells. Transcriptional targeting, the use of DNA regulatory promoter sequences to localize transgene expression, has been...

journal_title：International journal of oncology

authors： Lopez CA,Park JO,Mauceri HJ,Beckett MA,Weichselbaum RR,Posner MC

更新日期：2004-03-01 00:00:00

abstract：:Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...

journal_title：International journal of oncology

authors： Uchiyama T,Takahashi H,Endo H,Sugiyama M,Sakai E,Hosono K,Nagashima Y,Inayama Y,Wada K,Hippo Y,Nakajima A

更新日期：2011-10-01 00:00:00

abstract：:A serum-specific protein 'fingerprint' model was established which is capable of evaluating the effect of chemotherapy (gemcitabine) of pancreatic adenocarcinoma. We used SELDI-TOF-MS coupled with CM10 chips and bioinformatics tools to analyze a total of 45 mouse serum samples from three groups: the healthy control gr...

journal_title：International journal of oncology

authors： Cao L,Wang L,Wang G,Liu D,Yu J,Que R,Xie D

更新日期：2010-12-01 00:00:00

abstract：:Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH) are Hedgehog family ligands, which play key roles in embryogenesis and carcinogenesis, especially in pancreatic cancer and gastric cancer. Drosophila Costal-2 (Cos2) is a Hedgehog signaling regulator, interacting with Smoothened (Smo), Cubitus inter...

journal_title：International journal of oncology

authors： Katoh Y,Katoh M

更新日期：2004-12-01 00:00:00

abstract：:Ligands of the EGF/Heregulin family control the growth of epithelial cells by binding to receptors of the erbB family. By searching a large database of cDNA sequences at Human Genome Sciences Inc. we have identified a new encoded protein sequence containing all the conserved elements of the EGF/Heregulin family. The s...

journal_title：International journal of oncology

authors： Hijazi MM,Young PE,Dougherty MK,Bressette DS,Cao TT,Pierce JH,Wong LM,Alimandi M,King CR

更新日期：1998-11-01 00:00:00

abstract：:It has been reported that MUC-1 molecules devoid of the tandem repeat region (MUC-1/Y) are detected preferentially in carcinoma cells and are associated with their progression. However, its clinical significance is still unknown. We constructed a mouse colon adenocarcinoma cell line (MC-38) transduced with either MUC-...

journal_title：International journal of oncology

authors： Akagi J,Takai E,Tamori Y,Nakagawa K,Ogawa M

更新日期：2001-05-01 00:00:00

abstract：:Loss of heterozygosity (LOH) or allelic deletion at various loci has been reported in the majority of human tumors. The frequently deleted targets are believed to be tumor suppressor genes. Recent studies have identified the APC and MCC genes at 5q21, as putative tumor suppressor genes. The APC and MCC genes have been...

journal_title：International journal of oncology

authors： Gao X,Zacharek A,Grignon D,Liu H,Sakr W,Porter A,Chen Y,Honn K

更新日期：1995-01-01 00:00:00

abstract：:Spontaneous tumor regression is still one of the most puzzling events in human cancer. A cell culture model of malignant transformation designed to permit the study of this phenomenon in vitro was applied to examine reversion and re-expression of the transformed phenotype in two X-ray transformed mouse 10T1/2 cell clo...

journal_title：International journal of oncology

authors： Paquette B,Wagner R,Little J

更新日期：1996-04-01 00:00:00

abstract：:To determine the tissue specificity of the potential mutations in DNA polymerase beta (pol beta), alterations in the pol beta were examined in breast, prostate, and colorectal primary tumors. The pol beta is known to contribute to mammalian base excision repair and replication. Similar to colorectal cancer, a high occ...

journal_title：International journal of oncology

authors： Wang L,Banerjee S

更新日期：1995-02-01 00:00:00

abstract：:A murine B16 melanoma parental line (B16) and two clones either pigmented (B16P) or non-pigmented (B16NP) were cocultured as aggregates with mouse 3T3 fibroblasts. In vivo, these mixed aggregates developed more aggressive tumors in the mouse than corresponding pure aggregates. In vitro, the three pure cell lines secre...

journal_title：International journal of oncology

authors： Coucke P,Baramova E,Leprince P,Depauwgillet M,Foidart J,Bassleer R

更新日期：1994-11-01 00:00:00

abstract：:The exact mechanism behind the effect of hypoxia-inducible factor-1alpha (HIF-1alpha) on the proliferation and/or apoptosis of carcinoma cells is still a matter of debate. We treated a human gastric carcinoma cell line, MKN-1 (mutant P53), with 500 microM CoCl(2). A dual-phase pattern of HIF-1alpha expression with an ...

journal_title：International journal of oncology

authors： Ardyanto TD,Osaki M,Tokuyasu N,Nagahama Y,Ito H

更新日期：2006-09-01 00:00:00

abstract：:We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...

journal_title：International journal of oncology

authors： Takahara Y,Yogosawa S,Maruyama S,Watanabe N,Yokoyama H,Fukasawa K,Sukenaga Y,Kamiyama J,Izumi M,Wakada M,Zhang H,Yoshizawa K,Kawa S,Nikaido T,Sakai T

更新日期：2006-04-01 00:00:00

abstract：:Inhibin and activin, members of transforming growth factor beta (TGF beta) superfamily, have been localized immunohistochemically in fetal bovine heart endothelial cells (FBHE), suggesting that these cells produce inhibin/activin proteins. In addition, the mRNAs coding for alpha-, and beta A-subunits of inhibin/activi...

journal_title：International journal of oncology

authors： Ying S,Zhang Z

更新日期：1995-10-01 00:00:00

abstract：:Previous investigations have shown that interleukin-11 (IL-11) and the IL-11 receptor (IL-11R) have been correlated with the regulation of tumor progression, cellular growth and differentiation in several malignant tumors. The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric ...

journal_title：International journal of oncology

authors： Nakayama T,Yoshizaki A,Izumida S,Suehiro T,Miura S,Uemura T,Yakata Y,Shichijo K,Yamashita S,Sekin I

更新日期：2007-04-01 00:00:00

abstract：:Overexpression of HIF-1α, a transcription factor responsive to hypoxia, is frequently observed in malignant tumors, which sometimes show resistance to chemotherapy and radiation therapy. Consequently, decrease of HIF-1α through virotherapy offers a logical strategy for the treatment of aggressive tumors. In this study...

journal_title：International journal of oncology

authors： Cho IR,Kaowinn S,Moon J,Soh J,Kang HY,Jung CR,Oh S,Song H,Koh SS,Chung YH

更新日期：2015-05-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making ...

journal_title：International journal of oncology

authors： Park JG,Yuan Y

更新日期：1998-04-01 00:00:00

abstract：:Seventy-one patients with metastatic colorectal carcinoma(CRC) were treated with varying doses of the mouse monoclonal antibody (MAb) 17-1A. One patient achieved a partial remission (PR) (1%) with a survival duration of 114+ months. Further 10 patients showed a minor response (MR) or stable disease > 3 months (SD) (14...

journal_title：International journal of oncology

authors： Ragnhammar P,Frodin J,Hjelm A,Fagerberg J,Wersall P,Lindemalm C,Nilsson B,Fox K,Magnusson I,Ewerth S,Thor K,Secher E,Mellstedt H

更新日期：1995-11-01 00:00:00

abstract：:Myofibroblasts in the stroma of pancreatic cancers promote tumor proliferation, invasion and metastasis by increasing extracellular matrix and secretion of several growth factors. In contrast, the role of myofibroblasts at peritoneally disseminated sites of pancreatic cancer has not yet been determined. This study was...

journal_title：International journal of oncology

authors： Akagawa S,Ohuchida K,Torata N,Hattori M,Eguchi D,Fujiwara K,Kozono S,Cui L,Ikenaga N,Ohtsuka T,Aishima S,Mizumoto K,Oda Y,Tanaka M

更新日期：2014-07-01 00:00:00

abstract：:Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...

journal_title：International journal of oncology

authors： Patel MR,Sadiq AA,Jay-Dixon J,Jirakulaporn T,Jacobson BA,Farassati F,Bitterman PB,Kratzke RA

更新日期：2012-02-01 00:00:00

abstract：:Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorub...

journal_title：International journal of oncology

authors： Mattern J,Volm M

更新日期：1992-11-01 00:00:00

abstract：:Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been frequently administered in colon cancer patients, low response rates to these single drug therapies were reported. It is therefore imperative to search for new targeted combination therapies t...

journal_title：International journal of oncology

authors： Ling LU,Lin H,Tan KB,Chiu GN

更新日期：2009-12-01 00:00:00

abstract：:2-Phenyl-4-quinolone series compounds have exhibited growth inhibitory influence on several human cancer cell lines. In this study, we investigated the effects of 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) on viability, cell cycle and apoptotic cell death which occurred in different leukemia c...

journal_title：International journal of oncology

authors： Huang SM,Yang JS,Tsai SC,Chen MH,Hsu MH,Lin HY,Chou LC,Chinag JH,Lee KH,Huang LJ,Kuo SC

更新日期：2011-05-01 00:00:00

abstract：:Stromal cells isolated from lymph nodes of adult T-cell leukemia/lymphoma (ATL) patients were cultured. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. The rate of human T lymphotropic virus type...

journal_title：International journal of oncology

authors： Joh T,Yamada Y,Seto M,Nakamura S,Ohmoto Y,Kamihira S,Tomonaga M,Shiku H

更新日期：1996-10-01 00:00:00

abstract：:The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...

journal_title：International journal of oncology

authors： Lee WS,Park YL,Kim N,Oh HH,Son DJ,Kim MY,Oak CY,Chung CY,Park HC,Kim JS,Myung DS,Cho SB,Joo YE

更新日期：2015-05-01 00:00:00

abstract：:Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor-β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that pho...

journal_title：International journal of oncology

authors： Jung KH,Ryu YL,Lee HS,Lee H,Son MK,Yan HH,Hong SW,Ryu JK,Hong S,Suh JK,Hong SS

更新日期：2013-06-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00

abstract：:We review our recent experience with intensity-modulated radiation therapy (IMRT) and conventional three-dimensional radiation therapy (C3DRT) in advanced head and neck cancer. Sixty-nine patients with Stage IV head and neck cancer (and stage III base of tongue and hypopharynx) enrolled in a Phase II study of definiti...

journal_title：International journal of oncology

authors： Milano MT,Vokes EE,Kao J,Jackson W,List MA,Stenson KM,Witt ME,Dekker A,MacCracken E,Garofalo MC,Chmura SJ,Weichselbaum RR,Haraf DJ

更新日期：2006-05-01 00:00:00

abstract：:We have previously shown that the genotoxin-induced apoptosis in mouse embryo fibroblasts was enhanced by the extracellular matrix protein fibronectin (FN). In the present study, we tested the hypothesis that FN regulates the DNA damage response (DDR) signaling pathways in HCT116 (p53-wt) and HT29 (p53-mut) human colo...

journal_title：International journal of oncology

authors： DE Wever O,Sobczak-Thépot J,Vercoutter-Edouart AS,Michalski JC,Ouelaa-Benslama R,Stupack DG,Bracke M,Wang JYJ,Gespach C,Emami S

更新日期：2011-08-01 00:00:00

abstract：:The effects of retinoic acid (RA) and its analogs, all-trans RA, 9-cis RA and 13-cis RA, were investigated in human breast cancer MCF-7 cells and immortalized breast epithelial cell line MCF-10A. RA inhibited the telomerase activity of MCF-7 cells in a wide range of concentrations. RA at 10 microM also inhibited the g...

journal_title：International journal of oncology

authors： Choi SH,Kang HK,Im EO,Kim YJ,Bae YT,Choi YH,Lee KH,Chung HY,Chang HK,Kim ND

更新日期：2000-11-01 00:00:00

abstract：:According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...

journal_title：International journal of oncology

authors： Furihata M,Sonobe H,Ohtsuki Y

更新日期：1995-06-01 00:00:00