Abstract:
:To determine the tissue specificity of the potential mutations in DNA polymerase beta (pol beta), alterations in the pol beta were examined in breast, prostate, and colorectal primary tumors. The pol beta is known to contribute to mammalian base excision repair and replication. Similar to colorectal cancer, a high occurrence of mutations as 87-bp deletion in the catalytic domain of the pol beta removing 29 amino acids was observed in breast cancer. Contrary to breast and colorectal tumors, a low occurrence of mutation as a single base (T) deletion at the position coding for amino acid 181 of the pol beta was associated with prostate cancer. The missing T changed the codon from TTC to TCA (phenylalanine to serine), causing a frame shift.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Wang L,Banerjee Ssubject
Has Abstractpub_date
1995-02-01 00:00:00pages
459-63issue
2eissn
1019-6439issn
1791-2423journal_volume
6pub_type
杂志文章abstract::The identification of cell surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene expression analysis. The data indicate that there a...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2007-02-01 00:00:00
abstract::The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::Bone morphogenetic protein 7 (BMP-7) is an important regulator of cell development and differentiation of various organs. Tumorigenesis and tumor progression are also strongly associated with changes of the fate of cells which are highly differentiated in healthy tissues. Therefore, we studied the role of BMP-7 in bre...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::Elevated levels of p21WAF1/CIP1, an important mediator of DNA repair, have been observed in various aggressive tumors as well as linked to chemoresistance. We examined whether heregulin (HRG), a member of the EGF-like growth factor family closely related to breast cancer tumorigenesis and metastasis, modulates p21WAF1...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Thirty-four children with newly diagnosed acute nonlymphoblastic leukemia were analysed for the expression of P-glycoprotein (P-170), glutathione S-transferase-pi, (GST-pi) topoisomerase II (Topo II) and the proliferation antigen Ki-67 by the streptavidin-biotin-peroxidase method. Overexpression of P-170 was present i...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.4.841
更新日期:1994-10-01 00:00:00
abstract::Breast cancer cells can switch from estrogen receptor α (ER)- to human epidermal growth factor receptor (HER)-driven cell growth upon acquiring antiestrogen resistance. HER ligands are cleaved by metalloproteinases leading to release of active HER ligands, activation of HER receptors and consequently increased cell gr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2434
更新日期:2014-07-01 00:00:00
abstract::In the present study, we report the utility of transrectal ultrasonography guidance for laparoscopic radical prostatectomy (LRP), and the effect of a novel surgical approach of 'seven key elements of operative skill for the early recovery of urinary continence' ('7 key elements'). Among 170 patients who underwent lapa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2010.865
更新日期:2011-02-01 00:00:00
abstract::In a retrospective analysis of 91 consecutive oral carcinomas we reviewed all patient records and weighed clinicopathological parameters against the results of image DNA cytometry and p53 immunhistochemical staining of the initial diagnostic biopsies. Eighty-seven percent of the biopsies were either aneuploid or nondi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.4.915
更新日期:1994-10-01 00:00:00
abstract::It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::Meningiomas are the most commonly occurring tumors of the central nervous system including the brain and spinal cord. Malignant meningiomas are highly aggressive and frequently recur after surgical resection of the tumor. Our previous studies have reported that urokinase plasminogen activator receptor (uPAR) and matri...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3079
更新日期:2015-09-01 00:00:00
abstract::Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients wi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.1.187
更新日期:1997-07-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2651
更新日期:2014-12-01 00:00:00
abstract::MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2596
更新日期:2014-11-01 00:00:00
abstract::We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1282
更新日期:2012-03-01 00:00:00
abstract::Cisplatin-resistance has become a major impediment in the medical treatment of cancers such as osteosarcoma, the most common primary malignancy of bone. Since lysophosphatidic acid acyltransferase β (LPAATβ) was reported to be critically involved in osteosarcoma, our study investigated the role of LPAATβ in human oste...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3820
更新日期:2017-02-01 00:00:00
abstract::Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a the...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2015.3306
更新日期:2016-03-01 00:00:00
abstract::Glioma is the most prevalent and fatal primary tumor of the central nervous system in adults, while the development of effective therapeutic strategies in clinical practice remain a challenge. Nucleotide-binding domain leucine-rich family pyrin-containing 3 (NLRP3) has been reported to be associated with tumorigenesis...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4480
更新日期:2018-09-01 00:00:00
abstract::Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.6.1053
更新日期:1993-06-01 00:00:00
abstract::Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.6.1219
更新日期:1994-06-01 00:00:00
abstract::The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.4.979
更新日期:1994-10-01 00:00:00
abstract::Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4710
更新日期:2019-04-01 00:00:00
abstract::Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-01 00:00:00
abstract::Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2256
更新日期:2014-03-01 00:00:00
abstract::TGF-beta1 stimulates proliferation of WI38 human embryo fibroblasts but inhibits that of their SV40-transformed counterparts, VA13 cells. Protein expression levels of cyclins A, D1, E and that of cdk2 and cdk4 were not affected by TGF-beta1 in either of these cells. However, TGF-beta1-treatment increases cdk2 kinase a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.5.905
更新日期:1999-05-01 00:00:00
abstract::Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3000
更新日期:2015-07-01 00:00:00
abstract::Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target for anticancer drug design. However, few reports have described the constitutive activation of STAT3 in human sarcoma cells. In this study, we demonstrate that t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Many clinical studies highlight the dichotomous role of PRDXs in human cancers, where they can exhibit strong tumor-suppressive or tumor-promoting functions. Recent evidence suggests that lower expression of PRDXs correlates with cancer progression in colorectal cancer (CRC) or in esophageal squamous carcinoma. In the...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2208
更新日期:2014-02-01 00:00:00
abstract::Gamma linolenic acid (GLA) is an anti-cancer agent recently reported to inhibit tumour cell-matrix attachment. This study examined the effects of GLA on the adhesion of two tumour cell lines, HT115 (human colon) and MDA MB 231 (human breast), to an extracellular matrix, Matrigel. The action of GLA on focal adhesion ki...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.3.583
更新日期:1996-03-01 00:00:00
abstract::WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A, and demonstrated up-regulation of WNT10A in gastric cancer. Here, we investigated expression of WNT10A mRNA in various types of human cancer. WNT10A mRNA was detected in 10 out of 12 esophageal ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.5.997
更新日期:2001-11-01 00:00:00