High establishment efficiency of lymph node stromal cells which spontaneously produce multiple cytokines derived from adult T-cell leukemia/lymphoma patients.

abstract：:The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...

journal_title：International journal of oncology

authors： Joly B,Lecureur V,Puozzo C,Guillouzo A,Fardel O

更新日期：1996-11-01 00:00:00

abstract：:We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tum...

journal_title：International journal of oncology

authors： Shimose S,Sugita T,Nitta Y,Kubo T,Ikuta Y,Murakami T

更新日期：2001-09-01 00:00:00

abstract：:Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying development of multidrug-resistance in NB we established two neuroblastoma cell sublines resistant to vincristine (UKF-NB-3rVCR10) and doxorubicin (UKF-NB-3rDOX20...

journal_title：International journal of oncology

authors： Kotchetkov R,Driever PH,Cinatl J,Michaelis M,Karaskova J,Blaheta R,Squire JA,Von Deimling A,Moog J,Cinatl J Jr

更新日期：2005-10-01 00:00:00

abstract：:The retinoic acid receptor (RAR) beta gene is located in a region on chromosome 3p, which is frequently deleted in renal cell carcinoma. Since retinoic acid (RA) can inhibit cell proliferation and tumor formation, loss of RAR beta might contribute to oncogenesis of the kidney. This prompted us to examine RAR beta expr...

journal_title：International journal of oncology

authors： Vanderleede B,Opdenoordt T,Vandenbrink C,Ebert T,Vandersaag P

更新日期：1995-02-01 00:00:00

abstract：:We previously showed that the B cell leukemia cell line NALM-6 had the highest susceptibility among a number of leukemia cell lines to spiruchostatin B (SP-B), a potent histone deacetylase (HDAC) inhibitor. We also showed that SP-B-induced cytotoxicity depended on induction of apopt...

journal_title：International journal of oncology

authors： Kanno S,Maeda N,Tomizawa A,Yomogida S,Katoh T,Ishikawa M

更新日期：2012-09-01 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 ...

journal_title：International journal of oncology

authors： Liu L,Yang L,Chang H,Chen YN,Zhang F,Feng S,Peng J,Ren CC,Zhang XA

更新日期：2019-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) are involved in cell growth, apoptosis and differentiation. This study aimed to investigate the effects of HDACI scriptaid on histone modification, demethylation, cell growth, cell cycle and apoptosis in the RKO colorectal cancer cell line and screening for scriptaid-induced gen...

journal_title：International journal of oncology

authors： Lee EJ,Lee BB,Kim SJ,Park YD,Park J,Kim DH

更新日期：2008-10-01 00:00:00

abstract：:We have demonstrated the possibility that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system might be involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). In order to further clarify the role of the SDF-1/CXCR4 system in oral SCC, we examined the expression of CXCR4...

journal_title：International journal of oncology

authors： Almofti A,Uchida D,Begum NM,Tomizuka Y,Iga H,Yoshida H,Sato M

更新日期：2004-07-01 00:00:00

abstract：:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotensio...

journal_title：International journal of oncology

authors： Cheung NK,Kushner BH,Yeh SD,Larson SM

更新日期：1998-06-01 00:00:00

abstract：:Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major rol...

journal_title：International journal of oncology

authors： Kawaguchi M,Banno K,Yanokura M,Kobayashi Y,Kishimi A,Ogawa S,Kisu I,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2009-11-01 00:00:00

abstract：:The monocyte chemotactic protein 3 (MCP-3) belongs to the MCP subgroup of the CC chemokines and promotes chemotaxis of immune cells. MCP-1 is believed to play an important role in monocyte infiltration into tumor tissues; however, the relationship between tumor-infiltrating macrophage/microglia (TIM/M) and the express...

journal_title：International journal of oncology

authors： Okada M,Saio M,Kito Y,Ohe N,Yano H,Yoshimura S,Iwama T,Takami T

更新日期：2009-06-01 00:00:00

abstract：:Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different levels of regulation,...

journal_title：International journal of oncology

authors： Gómez DL,Farina HG,Gómez DE

更新日期：2013-11-01 00:00:00

abstract：:The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...

journal_title：International journal of oncology

authors： Lohmeyer M,Mason S,Gullick W

更新日期：1997-04-01 00:00:00

abstract：:Telomerase activation in differentiated cells is associated with cell immortalization. Detection of telomerase expression in cancer provides a potential biomarker to be evaluated in the diagnosis and prognosis of cancer patients. Analysis of telomerase activity in biopsy specimens may serve as a useful marker for the ...

journal_title：International journal of oncology

authors： Pearson AS,Chiao P,Zhang L,Zhang W,Larry L,Katz RL,Evans DB,Abbruzzese JL

更新日期：2000-08-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:A serum-specific protein 'fingerprint' model was established which is capable of evaluating the effect of chemotherapy (gemcitabine) of pancreatic adenocarcinoma. We used SELDI-TOF-MS coupled with CM10 chips and bioinformatics tools to analyze a total of 45 mouse serum samples from three groups: the healthy control gr...

journal_title：International journal of oncology

authors： Cao L,Wang L,Wang G,Liu D,Yu J,Que R,Xie D

更新日期：2010-12-01 00:00:00

abstract：:The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...

journal_title：International journal of oncology

authors： Goh HS,Elnatan J,Low CH,Smith DR

更新日期：1999-09-01 00:00:00

abstract：:Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in r...

journal_title：International journal of oncology

authors： Tsukamoto S,Honoki K,Fujii H,Tohma Y,Kido A,Mori T,Tsujiuchi T,Tanaka Y

更新日期：2012-01-01 00:00:00

abstract：:Multiple drug resistance is reported to be a major obstacle in treatment of osteosarcoma (OS). Research has demonstrated that small subsets of cells called cancer stem cells (CSCs) are responsible for multiple drug resistance. CSCs are potential targets for reversing chemoresistance. In the present study, we compared ...

journal_title：International journal of oncology

authors： Shang D,Wu J,Guo L,Xu Y,Liu L,Lu J

更新日期：2017-05-01 00:00:00

abstract：:Peripheral blood mononulear cells (PBMC) derived from 10 asymptomatic human T lymphotropic virus type I (HTLV-I) carriers were cultured for a short term (10-14 days) in the absence of exogenous antigens. In 5 carriers, when compared with 5 HTLV-I non-carriers an apparent increase in the proportion of CD8+ DR+ cells wa...

journal_title：International journal of oncology

authors： Yang H,Furukawa K,Shinzato O,Kamihira S,Moji K,Takemoto T,Shiku H

更新日期：1994-08-01 00:00:00

abstract：:An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

journal_title：International journal of oncology

authors： Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

更新日期：2011-07-01 00:00:00

abstract：:Gene amplification is an important phenomenon in the pathogenetics of malignancy. A method is defined which allows the determination of gene amplification from any sample from which RNA can be obtained, and requires no a priori knowledge of the cytogenetic or genomic state of the tumor. This method allows the determin...

journal_title：International journal of oncology

authors： Liang B

更新日期：1995-09-01 00:00:00

abstract：:We analyzed the representation of CD44 isoforms with both exons v9 and v10 among CD44 total amount and also examined correlation between their expression, clinical parameters and survival. We used a semi-quantitative RT-PCR reaction and a panel of 25 normal breast specimens, 10 mammary fibroadenomas, 8 cystic samples ...

journal_title：International journal of oncology

authors： Guriec N,Gairard B,Marcellin L,Wilk A,Calderoli H,Renaud R,Bergerat J,Oberling F

更新日期：1997-01-01 00:00:00

abstract：:To establish a prostate cancer model expressing prostate-specific antigen (PSA) with metastatic potential, LNCaP or PC-3 cells were inoculated into the testis of SCID mice, resulting in a 100% rate of tumor formation. A significant increase in serum PSA was found in mice with LNCaP xenografts. Circulating tumor cells ...

journal_title：International journal of oncology

authors： Koshida K,Endo Y,Kobayashi T,Imao T,Konaka H,Kadono Y,Uchibayashi T,Sasaki T,Namiki M

更新日期：1997-09-01 00:00:00

abstract：:Although HIF-1α is considered an attractive target for the development of cancer therapies, like other transcriptional factors, it has been regarded as 'undruggable'. The decoy approach is a new class of antigene strategy that can be used to modulate the function of endogenous transcriptional factors. Here, we designe...

journal_title：International journal of oncology

authors： Zhu X,Li Q,Li S,Chen B,Zou H

更新日期：2015-01-01 00:00:00

abstract：:The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...

journal_title：International journal of oncology

authors： Shimamoto R,Sawada T,Uchima Y,Inoue M,Kimura K,Yamashita Y,Yamada N,Nishihara T,Ohira M,Hirakawa K

更新日期：2004-06-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...

journal_title：International journal of oncology

authors： Rello-Varona S,Stockert JC,Cañete M,Acedo P,Villanueva A

更新日期：2008-06-01 00:00:00

abstract：:Dendritic cells play a major role in cellular immunity. The crucial steps of antigen presentation and processing by DCs may be limiting factors for adoptive cellular immunotherapy. Here, we investigated whether hyperthermia of human hepatocellular carcinoma (HCC) cells induces enhanced cytotoxic cellular immune respon...

journal_title：International journal of oncology

authors： Schueller G,Stift A,Friedl J,Dubsky P,Bachleitner-Hofmann T,Benkoe T,Jakesz R,Gnant M

更新日期：2003-06-01 00:00:00

abstract：:Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...

journal_title：International journal of oncology

authors： Nestal De Moraes G,Pereira Castro C,Salustiano EJ,Dumas ML,Costas F,Wing-Fai Lam E,Ribeiro Costa PR,Maia RC

更新日期：2019-12-01 00:00:00