Implication of retinoic Acid receptor-Beta in renal-cell carcinoma.

abstract：:It is well established that the tumor microenvironment plays a major role in the aggressive behavior of malignant solid tumors. Among cell types associated with tumor microenvironment, tumor-associated macrophages (TAMs) are the most influential for tumor progression. Breast cancer is characterized by having a large p...

journal_title：International journal of oncology

authors： Obeid E,Nanda R,Fu YX,Olopade OI

更新日期：2013-07-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...

journal_title：International journal of oncology

authors： Yin F,Liu X,Li D,Wang Q,Zhang W,Li L

更新日期：2013-04-01 00:00:00

abstract：:Gastric carcinoma may occur sporadically or in association with hereditary diseases, such as Peutz-Jehgers syndrome (PJS). The PJS gene (named STK11 or LKB1) was mapped to 19p13.3 and recently cloned. Germ-line mutations of the gene have been detected in familial PJS patients and are predicted to predispose STK11 carr...

journal_title：International journal of oncology

authors： Park WS,Moon YW,Yang YM,Kim YS,Kim YD,Fuller BG,Vortmeyer AO,Fogt F,Lubensky IA,Zhuang Z

更新日期：1998-09-01 00:00:00

abstract：:Two new tumor-suppressor genes, the cyclin dependent kinase 4 inhibitor gene (p16/CDKN2) and the von Hippel-Lindau disease gene (VHL), have been cloned and mapped on chromosomes 9p and 3p respectively, where putative tumor-suppressor genes of the oral squamous-cell carcinoma (SCC) may be present. In order to elucidate...

journal_title：International journal of oncology

authors： Uzawa K,Suzuki H,Yokoe H,Tanzawa H,Sato K

更新日期：1995-10-01 00:00:00

abstract：:Drug-resistance is a major contributing factor for the poor prognosis in patients with pancreatic cancer. We have shown previously that the irreversible ErbB family blocker afatinib, is more effective than the reversible EGFR tyrosine kinase inhibitor erlotinib in inhibiting the growth of human pancreatic cancer cells...

journal_title：International journal of oncology

authors： Ioannou N,Seddon AM,Dalgleish A,Mackintosh D,Solca F,Modjtahedi H

更新日期：2016-03-01 00:00:00

abstract：:Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...

journal_title：International journal of oncology

authors： Narayanan R,Kim HN,Narayanan NK,Nargi D,Narayanan B

更新日期：2012-01-01 00:00:00

abstract：:Human squamous cell carcinomas frequently overexpress the epidermal growth factor receptor (EGFR) and this is often associated with poor prognosis in patients with these cancers. The high level of expression of the EGFR provides an important target for therapy and we and others have shown that monoclonal antibodies (m...

journal_title：International journal of oncology

authors： Modjtahedi H,Affleck K,Stubberfield C,Dean C

更新日期：1998-08-01 00:00:00

abstract：:Benzyl isothiocyanate (BITC) is known for its pharmacological properties against malignant neoplasm, including bladder cancer (BC). The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR‑99a‑5p in BITC‑treated BC cells. A quantitative polymerase chain reaction (...

journal_title：International journal of oncology

authors： Lin JF,Tsai TF,Lin YC,Chen HE,Chou KY,Hwang TI

更新日期：2019-06-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome that is the main cause of inherited clear-cell renal cell carcinoma (ccRCC), which generally occurs in the form of multiple recurrent synchronized tumors. Affected patients are carriers of a germline mutation in the VHL tumor suppressor gene. Somati...

journal_title：International journal of oncology

authors： Gattolliat CH,Couvé S,Meurice G,Oréar C,Droin N,Chiquet M,Ferlicot S,Verkarre V,Vasiliu V,Molinié V,Méjean A,Dessen P,Giraud S,Bressac-De-Paillerets B,Gardie B,Tean Teh B,Richard S,Gad S

更新日期：2018-10-01 00:00:00

abstract：:Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...

journal_title：International journal of oncology

authors： Yang Y,Pham CD,Arlinghaus RB,Khillan JS,Singh B

更新日期：1998-05-01 00:00:00

abstract：:Serum CASA, CEA, CYFRA 21-1, NSE, MSA, TPA, and TPS were determined in patients with lung cancer (LC), benign lung disease (BL), and healthy control (HC) donors. Using predefined cutpoints, the cytokeratin-related markers TPA, TPS, and CYFRA showed the highest sensitivity in non-small cell lung cancer (TPA 69%, TPS 63...

journal_title：International journal of oncology

authors： Devine P,Yarker J,Fong K,McGuckin M,Scells B,Ward B,Thynne G,Zimmerman P

更新日期：1994-05-01 00:00:00

abstract：:We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...

journal_title：International journal of oncology

authors： Doucrasy S,Coll J,Barrois M,Joubel A,Prost S,Dozier C,Stehelin D,Riou G

更新日期：1993-05-01 00:00:00

abstract：:The effects of different substrate stiffness were investigated on epithelial-mesenchymal transition (EMT) of cervical cancer cell lines and the role of miR-106b and its target protein DAB2 therein. Cervical cancer cell lines HeLa and SiHa were cultured on artificial substrates with different stiffness prepared using d...

journal_title：International journal of oncology

authors： Piao J,You K,Guo Y,Zhang Y,Li Z,Geng L

更新日期：2017-06-01 00:00:00

abstract：:Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...

journal_title：International journal of oncology

authors： Nozaki Y,Isobe K,Nakashima I,Shimokata K

更新日期：1993-06-01 00:00:00

abstract：:This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substa...

journal_title：International journal of oncology

authors： Song JY,Jo HH,Kim MR,Lew YO,Ryu KS,Cha JH,Kang CS,Donahoe PK,MacLaughlin DT,Kim JH

更新日期：2012-06-01 00:00:00

abstract：:Cervical lymph node metastasis is the most common recurrence pattern of head and neck squamous cell carcinoma (HNSCC), and it is usually treated with radiation therapy and/or neck dissection. There has long been a desire for markers useful in predicting radiosensitivity to enable assignment of patients with recurrent ...

journal_title：International journal of oncology

authors： Ito Y,Kamijo T,Yokose T,Kawashima M,Ogino T,Ikeda H,Hayashi R,Sasaki S,Ochiai A

更新日期：2001-12-01 00:00:00

abstract：:We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha). High incidence of lymphoma development in this transgenic mouse model system was similar to lymphoma development in p53 knockout mice. In an effort to understand the molecular basis of lymphomagenesis...

journal_title：International journal of oncology

authors： Haidar MA,Manshouri T,Keating MJ,Kantarjian HM,Freireich EJ,Mehta K,Albitar M

更新日期：2000-03-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically where one of the mechanisms responsible for the invasion into facial bones occurs via the activation of osteoclasts. Copper has been demonstrated to play a key role in skeletal remodeling. However, the role of copper in cancer-assoc...

journal_title：International journal of oncology

authors： Morisawa A,Okui T,Shimo T,Ibaragi S,Okusha Y,Ono M,Nguyen TTH,Hassan NMM,Sasaki A

更新日期：2018-03-01 00:00:00

abstract：:Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypoxia is involved in ...

journal_title：International journal of oncology

authors： Kogita A,Togashi Y,Hayashi H,Sogabe S,Terashima M,De Velasco MA,Sakai K,Fujita Y,Tomida S,Takeyama Y,Okuno K,Nakagawa K,Nishio K

更新日期：2014-10-01 00:00:00

abstract：:Tumor necrosis factor‑associated apoptosis‑inducing ligand (TRAIL) is considered to be a potential therapeutic target for various types of cancer. However, colon cancer is difficult to treat due to its resistance to TRAIL. Therefore, various trials have been conducted to overcome TRAIL resistance in colon cancer. The ...

journal_title：International journal of oncology

authors： Kim B,Seo JH,Lee KY,Park B

更新日期：2020-03-01 00:00:00

abstract：:Inhibin and activin, members of transforming growth factor beta (TGF beta) superfamily, have been localized immunohistochemically in fetal bovine heart endothelial cells (FBHE), suggesting that these cells produce inhibin/activin proteins. In addition, the mRNAs coding for alpha-, and beta A-subunits of inhibin/activi...

journal_title：International journal of oncology

authors： Ying S,Zhang Z

更新日期：1995-10-01 00:00:00

abstract：:In the present study, the cc‑006cpm8 novel colon cell line was established from a sample of right colorectal adenocarcinoma obtained from a woman with liver metastasis. It was possible to culture this cell line for ≥100 passages in vitro with vigorous growth. Morphologically, the cells grew as several layers with tigh...

journal_title：International journal of oncology

authors： Chu X,Xue Y,Huo X,Wei J,Chen Y,Han R,Chen H,Su X,Zhang H,Gong Y,Chen J

更新日期：2019-07-01 00:00:00

abstract：:Mesothelioma is an aggressive tumor which is mainly derived from the pleura of lung. In the present study, we evaluated the anticancer effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor on human mesothelioma cells in relation to the levels of HDAC1, reactive oxygen species (ROS) a...

journal_title：International journal of oncology

authors： You BR,Park WH

更新日期：2016-05-01 00:00:00

abstract：:Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...

journal_title：International journal of oncology

authors： Umene K,Yanokura M,Banno K,Irie H,Adachi M,Iida M,Nakamura K,Nogami Y,Masuda K,Kobayashi Y,Tominaga E,Aoki D

更新日期：2015-04-01 00:00:00

abstract：:The regions upstream from the human N-myc gene were examined for both transcription and replication. The plasmids containing several N-myc regions linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to human neuroblastoma IMR32 cells. The results indicated that the region spanning fro...

journal_title：International journal of oncology

authors： Nakagawa T,Imamura Y,Iguchiariga S,Ariga H

更新日期：1994-09-01 00:00:00

abstract：:The tumour suppressor gene hypermethylated in cancer 1 (HIC1) is a transcriptional repressor, which functionally cooperates with p53. Loss of HIC1 function is associated with the development of various tumor entities. The aim of this study was to elucidate the relevance of CpG islan...

journal_title：International journal of oncology

authors： Eggers H,Steffens S,Grosshennig A,Becker JU,Hennenlotter J,Stenzl A,Merseburger AS,Kuczyk MA,Serth J

更新日期：2012-05-01 00:00:00

abstract：:The Raf/MEK/ERK signaling cascade has been extensively studied for its roles in growth and differentiation of a variety of cell types. Confliciting evidence exists regarding the function of classical MAPK signaling with regards to the development of chemotherapeutic drug resistance; some reports describe an pro-surviv...

journal_title：International journal of oncology

authors： Lee JT Jr,Steelman LS,McCubrey JA

更新日期：2005-06-01 00:00:00

abstract：:A major limitation of cancer chemotherapy is development of resistance. In this study, we analyzed KB-3-1 cells and adriamycin-selected multidrug resistant sublines KB-A1 and KB-A10 cells for mechanisms of resistance. KB-A10 cells are 10-fold more resistant than KB-A1 cells but have lower P-glycoprotein. Of the known ...

journal_title：International journal of oncology

authors： Villagra L,Darling A,Yassa D,Scheper R,Tritton T,Bhushan A

更新日期：1997-11-01 00:00:00

abstract：:We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly dif...

journal_title：International journal of oncology

authors： Moriya S,Yanagihara K,Fujita H,Kuzumaki N

更新日期：1994-12-01 00:00:00

abstract：:The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...

journal_title：International journal of oncology

authors： Chow LS,Wang X,Kwong DL,Sham JS,Tsao SW,Nicholls JM

更新日期：2000-07-01 00:00:00