Abstract：
:Two new tumor-suppressor genes, the cyclin dependent kinase 4 inhibitor gene (p16/CDKN2) and the von Hippel-Lindau disease gene (VHL), have been cloned and mapped on chromosomes 9p and 3p respectively, where putative tumor-suppressor genes of the oral squamous-cell carcinoma (SCC) may be present. In order to elucidate whether abnormalities of these genes could contribute to the tumorigenesis of oral SCC, genomic DNAs from 62 tissue samples of tumors (32 primary SCCs and 30 pre-cancerous lesions) and from 7 oral SCC cell lines were examined by polymerase chain reaction-single strand conformation polymorphism analysis and direct DNA sequencing. Four of 7 (57%) cell lines contained nonsense mutations or missense mutations in the p16/CDKN2 gene and 2 of 32 (6%) primary oral SCCs had nonsense mutations. Particularly, 3 of 4 nonsense mutations detected in the present study were found in codon 80 (CGA-->TGA; Arg-->Stop), suggesting that codon 80 was a mutational hot spot of the p16/CDKN2 gene. No VHL gene mutation was found in any subject. These results suggest that mutation of the VHL gene is not a common factor in the development of human oral SCC. In contrast, the p16/CDKN2 gene may be correlated with the progression of a subtype of this cancer.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Uzawa K,Suzuki H,Yokoe H,Tanzawa H,Sato Kdoi
10.3892/ijo.7.4.895subject
Has Abstractpub_date
1995-10-01 00:00:00pages
895-9issue
4eissn
1019-6439issn
1791-2423journal_volume
7pub_type
杂志文章abstract：:The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffin-embedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presen...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2011.1031
更新日期：2011-07-01 00:00:00
abstract：:Chromosomal aneuploidy is associated with invasive bladder cancer and one of the genes implicated in these changes is Aurora-A/STK15/BTAK, that is localized on chromosome 20q13 and encodes a centrosome-associated serine/threonine kinase. To better understand the association between Aurora-A/STK15 expression, tumor ane...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：:Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo_32_6_1189
更新日期：2008-06-01 00:00:00
abstract：:Collagen type I is an abundant component of the extracellular matrix and due to its longevity, constitutes a prominent target of non-enzymatic post-translational in vivo modifications such as carbamylation and glycation. These protein modifications involved in aging, renal diseases and diabetes, are linked to elevated...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2012.1393
更新日期：2012-06-01 00:00:00
abstract：:Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2019.4873
更新日期：2019-11-01 00:00:00
abstract：:Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...
journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC a...
journal_title：International journal of oncology
pub_type： 杂志文章,评审
doi：10.3892/ijo.2018.4441
更新日期：2018-08-01 00:00:00
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journal_title：International journal of oncology
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更新日期：2002-04-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant types of cancer, and is associated with high recurrence rates and a poor response to chemotherapy. Immune signatures in the microenvironment of HCC have not been well explored systematically. The aim of the present study was to identify prognostic immune sign...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2020.4998
更新日期：2020-05-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.7.4.759
更新日期：1995-10-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2017.3983
更新日期：2017-06-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2013.1804
更新日期：2013-04-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.2017.4207
更新日期：2018-02-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：10.3892/ijo.9.5.879
更新日期：1996-11-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
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journal_title：International journal of oncology
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
abstract：:Gene amplification is an important phenomenon in the pathogenetics of malignancy. A method is defined which allows the determination of gene amplification from any sample from which RNA can be obtained, and requires no a priori knowledge of the cytogenetic or genomic state of the tumor. This method allows the determin...
journal_title：International journal of oncology
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
