High incidence of high-risk HPV in benign and malignant lesions of the larynx.

abstract：:This study suggests that speckle-type POZ protein (SPOP) may be a tumor suppressor gene and its prognostic value in human glioma. Real-time quantitative RT-PCR (qRT‑PCR), western blotting, and immunohistochemical staining were used to examine SPOP expression in glioma tissues and normal brain (NB) tissues. The relatio...

journal_title：International journal of oncology

authors： Ding D,Song T,Jun W,Tan Z,Fang J

更新日期：2015-01-01 00:00:00

abstract：:In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. 5-CQA abrogated ...

journal_title：International journal of oncology

authors： In JK,Kim JK,Oh JS,Seo DW

更新日期：2016-05-01 00:00:00

abstract：:SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta‑analysis based on multiple...

journal_title：International journal of oncology

authors： Liu AG,Zhong JC,Chen G,He RQ,He YQ,Ma J,Yang LH,Wu XJ,Huang JT,Li JJ,Mo WJ,Qin XG

更新日期：2020-07-01 00:00:00

abstract：:Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...

journal_title：International journal of oncology

authors： Kijima H,Yamazaki H,Nakamura M,Scanlon KJ,Osamura RY,Ueyama Y

更新日期：2004-03-01 00:00:00

abstract：:Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...

journal_title：International journal of oncology

authors： Yang JY,Xia W,Hu MC

更新日期：2006-09-01 00:00:00

abstract：:The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid malignant tumors to alter the microenvironment represents an important characteristic through which tumor cells are able t...

journal_title：International journal of oncology

authors： Zhang X,Huang S,Guo J,Zhou L,You L,Zhang T,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:Dissemination of single tumor cells to the bone marrow is a common event in cancer. The clinical significance of cytokeratin-positive cells detected in the bone marrow of cancer patients is still a matter of debate. In gastric cancer, overexpression of the receptor (uPAR or CD87) for the serine protease urokinase-type...

journal_title：International journal of oncology

authors： Noack F,Helmecke D,Rosenberg R,Thorban S,Nekarda H,Fink U,Lewald J,Stich M,Schutze K,Harbeck N,Magdolen V,Graeff H,Schmitt M

更新日期：1999-10-01 00:00:00

abstract：:Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymi...

journal_title：International journal of oncology

authors： Nishioka K,Fujimori Y,Hashimoto-Tamaoki T,Kai S,Qiu H,Kobayashi N,Tanaka N,Westerman KA,Leboulch P,Hara H

更新日期：2003-10-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...

journal_title：International journal of oncology

authors： Jiao F,Hu H,Yuan C,Jin Z,Guo Z,Wang L,Wang L

更新日期：2014-10-01 00:00:00

abstract：:Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations. Previous studies suggested that imatinib mesylate (Gleevec) is effective in pre-clinical trials for glioblastoma. Also, chlorimipramine (Anafranil) is an anti-depressant drug in use in the clinic and ...

journal_title：International journal of oncology

authors： Bilir A,Erguven M,Oktem G,Ozdemir A,Uslu A,Aktas E,Bonavida B

更新日期：2008-04-01 00:00:00

abstract：:The cytosine analogue 5'-azacytidine (5'-aza) induces DNA hypomethylation by inhibiting DNA methyltransferase. In clinical trials, 5'-aza is widely used in epigenetic anticancer treatments. Accumulated evidence shows that cyclooxygenase-2 (COX-2) is overexpressed in various cancers, indicating that it may play a criti...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2015-10-01 00:00:00

abstract：:Progression of oral carcinomas associates with aberrant activation and inactivation of molecules that work in established or unknown pathways. Although mucosa‑associated lymphoid tissue 1 (MALT1) expressed in normal oral epithelium is inactivated in the aggressive subset of carcinomas with worse prognosis, phenotypic ...

journal_title：International journal of oncology

authors： Kawamoto Y,Ohyama Y,Chiba T,Yagishita H,Sakashita H,Imai K

更新日期：2013-09-01 00:00:00

abstract：:The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers. However, the function and molecular mechanisms of CXCR7 in human colorectal cancer (CRC) are still undefined. In the present study, sixty-eight cases of CRC tissues and corresponding adjac...

journal_title：International journal of oncology

authors： Li XX,Zheng HT,Huang LY,Shi DB,Peng JJ,Liang L,Cai SJ

更新日期：2014-10-01 00:00:00

abstract：:The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

journal_title：International journal of oncology

authors： Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

更新日期：1997-03-01 00:00:00

abstract：:Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...

journal_title：International journal of oncology

authors： Patel MR,Sadiq AA,Jay-Dixon J,Jirakulaporn T,Jacobson BA,Farassati F,Bitterman PB,Kratzke RA

更新日期：2012-02-01 00:00:00

abstract：:Currently, it is not entirely clear whether hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of COX-2 expression and epithelial-to-mesenchymal transition (EMT), and whether these events affect the prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolizati...

journal_title：International journal of oncology

authors： Huang M,Wang L,Chen J,Bai M,Zhou C,Liu S,Lin Q

更新日期：2016-05-01 00:00:00

abstract：:The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...

journal_title：International journal of oncology

authors： Chow LS,Wang X,Kwong DL,Sham JS,Tsao SW,Nicholls JM

更新日期：2000-07-01 00:00:00

abstract：:The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...

journal_title：International journal of oncology

authors： Shimamoto R,Sawada T,Uchima Y,Inoue M,Kimura K,Yamashita Y,Yamada N,Nishihara T,Ohira M,Hirakawa K

更新日期：2004-06-01 00:00:00

abstract：:We have utilized a series of glioma cell lines to study the effects of ionizing radiation on the regulation of proteins that contribute to cell cycle progression. While no alterations of cyclin E or cdk4 were detected, a high percentage of glioma cell lines exhibited constitutive overexpression of cdk2 protein and abe...

journal_title：International journal of oncology

authors： Pykett M,Azzam E,Little J

更新日期：1997-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is difficult to diagnose early, resulting in only 30% resection rate. HCC is a relatively chemo-resistant tumor, molecular targeted therapy can only benefit approximately 30% patients with liver cancer. Bufalin (Bu) is one of the topoisomerase II inhibitors, many studies have recently fo...

journal_title：International journal of oncology

authors： Sheng X,Sun X,Sun K,Sui H,Qin J,Li Q

更新日期：2016-10-01 00:00:00

abstract：:Angiogenic factors are major causes of tumor progression in hematological malignancies, particularly multiple myeloma, as well as solid tumors. The introduction of thalidomide as an anti-angiogenic agent in myeloma treatment has demonstrated the importance of angiogenic factors in the progression of myeloma. However, ...

journal_title：International journal of oncology

authors： Yata K,Otsuki T,Kurebayashi J,Uno M,Fujii T,Yawata Y,Takata A,Hyodoh F,Sugihara T

更新日期：2003-01-01 00:00:00

abstract：:Liver cancer is the fourth leading cause of cancer‑related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2 (PIM2), has been shown to be overexpressed in liver cancer, ...

journal_title：International journal of oncology

authors： Kronschnabl P,Grünweller A,Hartmann RK,Aigner A,Weirauch U

更新日期：2020-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers; however, the development of drugs to treat the condition has reached a plateau. Bortezomib (PS-341, Velcade®) is a proteasome inhibitor approved for the treatment of hematological malignancies, including multiple myeloma. A few trials of bortezomib, alone or i...

journal_title：International journal of oncology

authors： Hong YS,Hong SW,Kim SM,Jin DH,Shin JS,Yoon DH,Kim KP,Lee JL,Heo DS,Lee JS,Kim TW

更新日期：2012-07-01 00:00:00

abstract：:Autocrine fibroblast growth factor (FGF) signaling was genetically manipulated in human gliomas by an adenovirus-mediated strategy. Antisense inhibition of endogenous basic FGF (bFGF) expression showed inhibition of the proliferation of human glioma cells (U251MG, NMC-G1) without promoting apoptosis. The reduction in ...

journal_title：International journal of oncology

authors： Aoki T,Kato S,Fox JC,Okamoto K,Sakata K,Morimatsu M,Shigemori M

更新日期：2002-09-01 00:00:00

abstract：:We established new two protein-free culture subclones from murine well-characterized Ehrlich ascites carcinoma and P815 mastocytoma using intermittent protein-free culture performed previously for a protein-free subclone of fibrosarcoma (Gc-4 PF). The Ehrlich protein-free subclone (Ehrlich PF) grew much more slowly th...

journal_title：International journal of oncology

authors： Watanabe H,Chigira M

更新日期：1992-09-01 00:00:00

abstract：:Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...

journal_title：International journal of oncology

authors： Konduri S,Lakka SS,Tasiou A,Yanamandra N,Gondi CS,Dinh DH,Olivero WC,Gujrati M,Rao JS

更新日期：2001-09-01 00:00:00

abstract：:Breast cancer (BC) is the most frequently malignancy in women. Therefore, establishment of an animal model for the development of preventative measures and effective treatment for tumors is required. A novel heterogeneous spontaneous mammary tumor animal model of Kunming mice was generated. The purpose of this study w...

journal_title：International journal of oncology

authors： Zheng L,Zhou B,Meng X,Zhu W,Zuo A,Wang X,Jiang R,Yu S

更新日期：2014-12-01 00:00:00

abstract：:Shc protein is known to be related to cell proliferation and carcinogenesis. However, the involvement of Shc in hepatocellular carcinoma (HCC) remains unknown. In the present study, we report that p46 Shc is probably expressed in the nuclei of hepatocytes and/or cancer cells during the development of HCC in Long-Evans...

journal_title：International journal of oncology

authors： Yoshida S,Masaki T,Feng H,Yuji J,Miyauchi Y,Funaki T,Yoshiji H,Matsumoto K,Uchida N,Watanabe S,Kurokohchi K,Kuriyama S

更新日期：2004-10-01 00:00:00

abstract：:MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream...

journal_title：International journal of oncology

authors： Zhang H,Feng Z,Huang R,Xia Z,Xiang G,Zhang J

更新日期：2014-11-01 00:00:00

abstract：:Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients wi...

journal_title：International journal of oncology

authors： Wu C,Habib N,Mitry R,Reitsma P,Vandeventer S,Chamuleau R

更新日期：1997-07-01 00:00:00