Expression of angiogenic factors including VEGFs and the effects of hypoxia and thalidomide on human myeloma cells.

abstract：:The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy. Eight human glioma cell lines and twelve primary human glioma cell cultures were...

journal_title：International journal of oncology

authors： Ritz R,Müller M,Weller M,Dietz K,Kuci S,Roser F,Tatagiba M

更新日期：2005-12-01 00:00:00

abstract：:A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...

journal_title：International journal of oncology

authors： Tillotson J,Darzynkiewicz Z,Cohen L,Ronai Z

更新日期：1993-07-01 00:00:00

abstract：:The effects of prostaglandin E2 and indomethacin on carcinogenesis were studied in male Wistar rats. Of the rats, those treated with MNNG (MNNG group) were given 1 ml of 0.1% solution of MNNG in distilled water by intrarectal instillation every day for 14 days. The diet for the rats treated with Indomethacin and MNNG ...

journal_title：International journal of oncology

authors： Yamaguchi A,Goi T,Nakagawara G,Ishida T,Miyazaki I

更新日期：1993-08-01 00:00:00

abstract：:The development of clinical agents remains a costly and time-consuming process. Although identification of new uses of existing drugs has been recognized as a more efficient approach for drug discovery than development of novel drugs, little screening of drugs that might be used for a rare malignant tumor such as oste...

journal_title：International journal of oncology

authors： Oi T,Asanuma K,Matsumine A,Matsubara T,Nakamura T,Iino T,Asanuma Y,Goto M,Okuno K,Kakimoto T,Yada Y,Sudo A

更新日期：2016-12-01 00:00:00

abstract：:Neoadjuvant chemotherapy with docetaxel for advanced breast cancer can improve the radicality for a subset of patients, but some patients suffer from severe adverse drug reactions without any benefit. To establish a method for predicting responses to docetaxel, we analyzed gene expression profiles of biopsy materials ...

journal_title：International journal of oncology

authors： Zembutsu H,Suzuki Y,Sasaki A,Tsunoda T,Okazaki M,Yoshimoto M,Hasegawa T,Hirata K,Nakamura Y

更新日期：2009-02-01 00:00:00

abstract：:We examined the effects of suppressing multidrug resistance-associated protein (MRP) and multidrug resistance 1 (MDR1) gene expression in HCT-8DDP human colon cancer cell lines, which showed both cisplatin and multidrug resistance. Hammerhead ribozymes, designed to cleave MRP mRNA (anti-MRP Rz) and MDR1 mRNA (anti-MDR...

journal_title：International journal of oncology

authors： Nagata J,Kijima H,Hatanaka H,Asai S,Miyachi H,Abe Y,Yamazaki H,Nakamura M,Watanabe N,Mine T,Kondo T,Scanlon KJ,Ueyama Y

更新日期：2002-11-01 00:00:00

abstract：:Peptide vaccine treatment has attracted attention in recent years as a new therapy option for chemotherapy‑resistant, advanced, unresectable cancer. The safety of peptide vaccination with HLA-A*2402-restricted URLC10-A24-177 and VEGFR1-A12-9 1084 epitope peptides (fixed 2-mg dose) was investigated in a phase I clinica...

journal_title：International journal of oncology

authors： Higashihara Y,Kato J,Nagahara A,Izumi K,Konishi M,Kodani T,Serizawa N,Osada T,Watanabe S

更新日期：2014-03-01 00:00:00

abstract：:Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients wi...

journal_title：International journal of oncology

authors： Wu C,Habib N,Mitry R,Reitsma P,Vandeventer S,Chamuleau R

更新日期：1997-07-01 00:00:00

abstract：:Cancer stem cells (CSC) exhibit therapy resistance and drive self-renewal of the tumour, making cancer stem cells an important target for therapy. The PI3K signalling pathway has been the focus of considerable research effort, including in glioblastoma (GBM), a cancer that is notoriously resistant to conventional ther...

journal_title：International journal of oncology

authors： Jones NM,Rowe MR,Shepherd PR,McConnell MJ

更新日期：2016-07-01 00:00:00

abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

journal_title：International journal of oncology

authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

更新日期：2007-10-01 00:00:00

abstract：:Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutation...

journal_title：International journal of oncology

authors： Furihata M,Shuin T,Takeuchi T,Sonobe H,Ohtsuki Y,Akiyama Y,Yuasa Y

更新日期：2000-03-01 00:00:00

abstract：:The intention of a surveillance program to monitor prostate cancer patients is to detect recurrence of disease as soon as possible and institute therapy at the time of recurrence in order to improve the chance of cure or extend survival. We analyzed the cost of four surveillance programs for prostate cancer. As PSA le...

journal_title：International journal of oncology

authors： Schapira D,Jarrett A

更新日期：1993-03-01 00:00:00

abstract：:Cytokine expression in a tumor microenvironment can impact both host defense against the tumor and tumor cell survival. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical associations with ovarian cancer. We analyzed the expression of 16 cytokine genes (IL-1α, IL-1β, I...

journal_title：International journal of oncology

authors： Yanaihara N,Anglesio MS,Ochiai K,Hirata Y,Saito M,Nagata C,Iida Y,Takakura S,Yamada K,Tanaka T,Okamoto A

更新日期：2012-09-01 00:00:00

abstract：:We purified and identified eight xanthones from mangosteen (Garcinia mangostana L.) and investigated whether these compounds inhibited the activities of mammalian DNA polymerases (Pols) and human DNA topoisomerases (Topos). β-Mangostin was the strongest inhibitor of both mammalian Pols and human Topos among the isolat...

journal_title：International journal of oncology

authors： Onodera T,Takenaka Y,Kozaki S,Tanahashi T,Mizushina Y

更新日期：2016-03-01 00:00:00

abstract：:Acquirement of multi-drug resistance by tumor cells represents a major obstacle in the management of prostate cancer. Such resistance was demonstrated in the androgen-independent DU-145 cells in response to paclitaxel and the mechanisms by which these cell develops resistance was not understood. The objective of this ...

journal_title：International journal of oncology

authors： Flynn V Jr,Ramanitharan A,Moparty K,Davis R,Sikka S,Agrawal KC,Abdel-Mageed AB

更新日期：2003-08-01 00:00:00

abstract：:Tissue samples from a malignant melanoma of the anal canal and its local metastasis were short-term cultured and analyzed cytogenetically. Complex chromosome aberrations were found in the primary tumor, yielding the karyotype 49-50,X,-Y,der(1)t(1;13)(q44;q12),+der(2)t(2;8) (q31;q12),der(6)t(5;6)(q13;q21),+del(6)(q12q2...

journal_title：International journal of oncology

authors： Bardi G,Fenger C,Pandis N,Mitelman F,Heim S

更新日期：1995-03-01 00:00:00

abstract：:Gene amplifications occurring in the q13 band of chromosome 11 are frequently observed in head and neck squamous cell carcinomas. In order to determine the relative frequency of amplification in 5 distinct 11q13 loci and their relation with clinical data, tumor DNAs from 31 patients - including 26 who had undergone ne...

journal_title：International journal of oncology

authors： Parise O,Janot F,Guerry R,Fortin A,Luboinski B,Tursz T,Schwaab G,Busson P

更新日期：1994-08-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are potentially mutagenic/carcinogenic lesions. Induction of DSBs triggers phosphorylation of histone H2AX on Ser-139. Phosphorylated H2AX (gammaH2AX) can be detected immunocytochemically, and the intensity of gammaH2AX immunofluorescence (IF), reflecting the number of gammaH2AX-IF foci...

journal_title：International journal of oncology

authors： Albino AP,Huang X,Jorgensen ED,Gietl D,Traganos F,Darzynkiewicz Z

更新日期：2006-06-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...

journal_title：International journal of oncology

authors： Rello-Varona S,Stockert JC,Cañete M,Acedo P,Villanueva A

更新日期：2008-06-01 00:00:00

abstract：:Phosphorylation of histone H2AX (gammaH2AX) is a sensitive marker of DNA damage, particularly induction of DNA double-strand breaks. Using multiparameter cytometry we explored the effects of doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types of endometrioid adenocarcinoma cell lines (HEC-1A, H...

journal_title：International journal of oncology

authors： Ikeda M,Kurose A,Takatori E,Sugiyama T,Traganos F,Darzynkiewicz Z,Sawai T

更新日期：2010-05-01 00:00:00

abstract：:Acquired drug resistance to chemotherapy is a major problem in the treatment of cancer. After primary surgical intervention, followed by chemotherapy treatments, the majority of patients develop disease recurrence. This is due to tumor cell heterogeneity and genetic instability. In contrast to tumor cells, proliferati...

journal_title：International journal of oncology

authors： Benouchan M,Colombo BM

更新日期：2005-08-01 00:00:00

abstract：:Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prost...

journal_title：International journal of oncology

authors： Li H,Gu Y,Miki J,Hukku B,McLeod DG,Hei TK,Rhim JS

更新日期：2007-09-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. Genetic polymorphisms that decrease MTHFR activity result in an altered cancer risk depending on folic acid intake. In this study we examined the C677T an...

journal_title：International journal of oncology

authors： Singal R,Ferdinand L,Das PM,Reis IM,Schlesselman JJ

更新日期：2004-11-01 00:00:00

abstract：:Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent. The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamo...

journal_title：International journal of oncology

authors： Cho JH,Shin JC,Cho JJ,Choi YH,Shim JH,Chae JI

更新日期：2015-01-01 00:00:00

abstract：:Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...

journal_title：International journal of oncology

authors： Zhang MH,Hu YD,Xu Y,Xiao Y,Luo Y,Song ZC,Zhou J

更新日期：2013-04-01 00:00:00

abstract：:In a retrospective analysis of 91 consecutive oral carcinomas we reviewed all patient records and weighed clinicopathological parameters against the results of image DNA cytometry and p53 immunhistochemical staining of the initial diagnostic biopsies. Eighty-seven percent of the biopsies were either aneuploid or nondi...

journal_title：International journal of oncology

authors： Hogmo A,Munckwikland E,Kuylenstierna R,Lindholm J,Auer G

更新日期：1994-10-01 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra-cranial solid tumor in children and despite aggressive therapy survival rates remain low. One of the contributing factors for low survival rates is aggressive tumor angiogenesis, which is known to increase due to radiation, one of the standard therapies for neuroblastoma. Th...

journal_title：International journal of oncology

authors： Boyineni J,Tanpure S,Gnanamony M,Antony R,Fernández KS,Lin J,Pinson D,Gondi CS

更新日期：2016-10-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common solid neoplasm of adult kidney, and the major treatment for metastatic RCC (mRCC) is molecular targeted therapy. Sorafenib, as a multi-targeted tyrosine kinase inhibitor (TKI), has significantly improved clinical outcomes of mRCC patients. However, complete or long-term re...

journal_title：International journal of oncology

authors： Zhang P,Xing Z,Li X,Song Y,Zhao J,Xiao Y,Xing Y

更新日期：2016-04-01 00:00:00

abstract：:Oxygen tension measurements were made in three tumors: (i) the murine FSaII fibrosarcoma, (ii) the rat 9L gliosarcoma and (iii) the rat 13672 mammary adenocarcinoma using a pO2 histograph. Tumor oxygenation measurements were made while the animals breathed air or breathed carbogen (95% oxygen/5% carbon dioxide). Pento...

journal_title：International journal of oncology

authors： Teicher B,Sotomayor E,Robinson M,Dupuis N,Schwartz G,Frei E

更新日期：1993-01-01 00:00:00

abstract：:An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

journal_title：International journal of oncology

authors： Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

更新日期：2011-07-01 00:00:00