Effects of linoleic-Acid on mammary-tumor cell-proliferation are associated with changes in p53 protein expression.

abstract：:A precise diagnosis of peritoneal dissemination is necessary to determine the appropriate treatment strategy for colorectal cancer. However, small peritoneal dissemination is difficult to diagnose. 5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism. The administration of 5-ALA to cancer pati...

journal_title：International journal of oncology

authors： Kondo Y,Murayama Y,Konishi H,Morimura R,Komatsu S,Shiozaki A,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Takahashi K,Inoue K,Nakajima M,Otsuji E

更新日期：2014-07-01 00:00:00

abstract：:Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...

journal_title：International journal of oncology

authors： Thews O,Lambert C,Kelleher DK,Biesalski HK,Vaupel P,Frank J

更新日期：2005-09-01 00:00:00

abstract：:The purpose of the study was to determine whether the organ environment can influence the response of colon cancer cells to chemotherapy. The highly metastatic human colon cancer cell line KM12L4, previously selected for production of liver metastases in nude mice, was injected into the cecal wall and into the spleen ...

journal_title：International journal of oncology

authors： Wilmanns C,Fan D,Obrian C,Radinsky R,Bucana C,Tsan R,Fidler I

更新日期：1993-09-01 00:00:00

abstract：:Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...

journal_title：International journal of oncology

authors： Devor EJ,Gonzalez-Bosquet J,Thiel KW,Leslie KK

更新日期：2020-12-01 00:00:00

abstract：:Cervical lymph node metastasis is the most common recurrence pattern of head and neck squamous cell carcinoma (HNSCC), and it is usually treated with radiation therapy and/or neck dissection. There has long been a desire for markers useful in predicting radiosensitivity to enable assignment of patients with recurrent ...

journal_title：International journal of oncology

authors： Ito Y,Kamijo T,Yokose T,Kawashima M,Ogino T,Ikeda H,Hayashi R,Sasaki S,Ochiai A

更新日期：2001-12-01 00:00:00

abstract：:Overexpression of inducible nitric oxide synthase (iNOS) and the resultant overproduction of NO has been implicated in neuronal inflammatory diseases. Leptomycin B (LMB), a metabolite of Streptomyces, has been identified as a specific inhibitor of CRM1 nuclear export receptor. In this study, we evaluated the effect of...

journal_title：International journal of oncology

authors： Jang BC,Sung SH,Park JG,Park JW,Suh MH,Choi IH,Yoshida M,Yoo SK,Suh SI

更新日期：2006-12-01 00:00:00

abstract：:There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-κB. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been perform...

journal_title：International journal of oncology

authors： Huang J,Guo P,Ma D,Lin X,Fang Q,Wang J

更新日期：2016-07-01 00:00:00

abstract：:Breast cancer is the neoplasia with the highest incidence in women worldwide. Proteomics approaches have accelerated the discovery of diagnostic and prognostic biomarkers. Here, we compared the proteomic profiles of breast tumors versus non-tumoral tissues in order to identify modul...

journal_title：International journal of oncology

authors： Fonseca-Sánchez MA,Rodríguez Cuevas S,Mendoza-Hernández G,Bautista-Piña V,Arechaga Ocampo E,Hidalgo Miranda A,Quintanar Jurado V,Marchat LA,Alvarez-Sánchez E,Pérez Plasencia C,López-Camarillo C

更新日期：2012-08-01 00:00:00

abstract：:Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...

journal_title：International journal of oncology

authors： Koseki J,Colvin H,Fukusumi T,Nishida N,Konno M,Kawamoto K,Tsunekuni K,Matsui H,Doki Y,Mori M,Ishii H

更新日期：2015-03-01 00:00:00

abstract：:The ability of lonidamine (LND), an energolytic derivative of indazol-carboxylic acid, to modulate the cytotoxic activity of idarubicin (IDA) and doxorubicin (DX) was investigated in two human lymphoma cell lines (H9 and U937). A different pattern of interaction between the drugs was observed as a function of treatmen...

journal_title：International journal of oncology

authors： Zaffaroni N,Villa R,Gornati D,Folini M,Silvestrini R

更新日期：1997-10-01 00:00:00

abstract：:Elderly patients with advanced non-small cell lung cancer (NSCLC) require chemotherapy that is effective and minimally toxic. We evaluated the activity of a combination of vinorelbine and 5-fluorouracil (5-FU)/UFT (a fixed combination of tegafur and uracil) in vitro and in vivo to establish a rationale for clinical us...

journal_title：International journal of oncology

authors： Matsumoto S,Igishi T,Hashimoto K,Kodani M,Shigeoka Y,Nakanishi H,Touge H,Kurai J,Makino H,Takeda K,Yasuda K,Hitsuda Y,Shimizu E

更新日期：2004-11-01 00:00:00

abstract：:Cutaneous infantile hemangioma progresses through proliferation and involution phases. Since treatment with interferon, a negative regulator of angiogenesis, accelerates the involution phase, we hypothesized that cutaneous infantile hemangioma is associated with an imbalance between endogenous positive and negative re...

journal_title：International journal of oncology

authors： Bielenberg DR,Bucana CD,Sanchez R,Mulliken JB,Folkman J,Fidler IJ

更新日期：1999-03-01 00:00:00

abstract：:Cyclin-dependent kinase (CDK) inhibitor p27Kip1 is a diagnostic and prognostic marker of various malignancies. Low expression of p27Kip1 reflects poor prognosis, and an inverse correlation between the expression of p27Kip1 and degree of tumor malignancy has been reported. Because p27Kip1 mutation is extremely rare in ...

journal_title：International journal of oncology

authors： Supriatno,Harada K,Yoshida H,Sato M

更新日期：2005-09-01 00:00:00

abstract：:New aromatase inhibitors are an exciting treatment option for postmenopausal women with hormone sensitive breast cancer. They have been shown to reduce tumors in a significant number of patients, and exhibit definite antitumor activity at a relatively low daily dose, and are highly potent, highly selective, and well-t...

journal_title：International journal of oncology

authors： Crucitta E,Lorusso V,Attolico M,Sambiasi D,Mazzei A,De Lena M

更新日期：2000-11-01 00:00:00

abstract：:Integrin alpha 6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin alpha 6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumor...

journal_title：International journal of oncology

authors： Mimori K,Mori M,Begum N,Tanaka S,Haraguchi M,Ueo H,Karimine N,Akiyoshi T,Barnard G

更新日期：1997-11-01 00:00:00

abstract：:To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...

journal_title：International journal of oncology

authors： Kohnoe S,Maehara Y,Takahashi I,Yoshida M,Emi Y,Baba H,Sugimachi K

更新日期：1993-11-01 00:00:00

abstract：:It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...

journal_title：International journal of oncology

authors： Katiyar SK

更新日期：2002-12-01 00:00:00

abstract：:Combination therapy is a promising and prevalent strategy for osteosarcoma treatment. Curcumin (CUR), as a chemosensitizer, improves the antitumor effect of first‑line chemotherapy drugs. However, due to its poor solubility and instability in physiological conditions, the bioavailability of CUR is limited. In order to...

journal_title：International journal of oncology

authors： Yang Z,Liu J,Lu Y

更新日期：2020-08-01 00:00:00

abstract：:Gliomas are malignant brain tumors thought to arise through multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cyclin D1 gene encodes a proto-oncogenic cell cycle regulator implicated in the pathogenesis of several types of cancer, including gliomas. Northe...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-09-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:Over the past few decades, there has been a tremendous increase in cancer biology data and treatment. Cancer research has opened exciting new areas of cellular and molecular biology. Month by month, new genes which regulate the carcinogenesis process are being discovered. The result is an incredible knowledge of cance...

journal_title：International journal of oncology

authors： Kanduc D,Bannasch P,Farber E

更新日期：1999-12-01 00:00:00

abstract：:A disintegrin and metalloproteinase-17 (ADAM17) can cut and release a wide variety of epidermal growth factor receptor (EGFR) ligands to promote survival, invasion and proliferation of cancer cell, and therefore, is considered to be a potential therapeutic target for cancer. The main goal of the present study was to o...

journal_title：International journal of oncology

authors： Meng X,Hu B,Hossain MM,Chen G,Sun Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-...

journal_title：International journal of oncology

authors： Deforzh E,Vargas TR,Kropp J,Vandamme M,Pinna G,Polesskaya A

更新日期：2016-12-01 00:00:00

abstract：:Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...

journal_title：International journal of oncology

authors： Nowak A,Grzegrzółka J,Kmiecik A,Piotrowska A,Matkowski R,Dzięgiel P

更新日期：2018-02-01 00:00:00

abstract：:We previously reported in a retrospective study that CEA-based RT-PCR was useful for predicting the prognosis of patients with node-negative colorectal cancer. RT-PCR is well established for laboratory use, but many issues remain to be resolved prior to its clinical application. In addition to the false positive rate ...

journal_title：International journal of oncology

authors： Takayama O,Yamamoto H,Ikeda K,Ishida H,Kato T,Okuyama M,Kanou T,Fukunaga M,Tominaga S,Morita S,Fujie Y,Fukunaga H,Ikenaga M,Ikeda M,Ohue M,Sekimoto M,Kikkawa N,Monden M

更新日期：2004-09-01 00:00:00

abstract：:Multiple myeloma (MM) patients initially respond to conventional therapy, however, many develop resistance and have recurrences. We have reported in other tumors that the transcription factor Yin Yang 1 (YY1) is a resistant factor and, thus, we hypothesized that YY1 may be over-expressed in MM. Significantly, higher e...

journal_title：International journal of oncology

authors： Huerta-Yepez S,Liu H,Baritaki S,Del Lourdes Cebrera-Muñoz M,Rivera-Pazos C,Maldonado-Valenzuela A,Valencia-Hipolito A,Vega MI,Chen H,Berenson JR,Bonavida B

更新日期：2014-09-01 00:00:00

abstract：:WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A, and demonstrated up-regulation of WNT10A in gastric cancer. Here, we investigated expression of WNT10A mRNA in various types of human cancer. WNT10A mRNA was detected in 10 out of 12 esophageal ...

journal_title：International journal of oncology

authors： Kirikoshi H,Inoue S,Sekihara H,Katoh M

更新日期：2001-11-01 00:00:00

abstract：:Selenium is a trace nutrient element that protects cells against oxidative damage. In this study, the potential of selenium to improve stem cell potency through active proliferation and migration of 3T3-L1 preadipocytes was investigated, together with the underlying molecular mechanisms. The results indicated that sel...

journal_title：International journal of oncology

authors： Park SH,Kim JH,Nam SW,Kim BW,Kim GY,Kim WJ,Choi YH

更新日期：2014-01-01 00:00:00

abstract：:Dickkopf‑related protein 3 (DKK3), which is a member of the Dickkopf WNT signaling pathway inhibitor family, is considered to be a tumor suppressor, due to its reduced expression in cancer cells and its ability to induce apoptosis when overexpressed by adenovirus. However, our previous study demonstrated alternative f...

journal_title：International journal of oncology

authors： Katase N,Nishimatsu SI,Yamauchi A,Yamamura M,Fujita S

更新日期：2019-03-01 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most unfavorable prognostic tumor, and immediate growth and distant metastasis are important factors associated with the poor prognosis of patients with this disease. Standard and variant isoforms of CD44 are associated with tumor growth, metastasis, and epithelial-mesenchymal tr...

journal_title：International journal of oncology

authors： Miwa T,Nagata T,Kojima H,Sekine S,Okumura T

更新日期：2017-09-01 00:00:00