Abstract:
:IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-3, and that this regulation depends on nuclear localization of IMP-3. In the present study, we show that as a first step following a knock-down of IMP-3, the protein levels of the cyclins rapidly decrease, while their mRNAs remain stable and associated with the polyribosomes, though not translated. We have elucidated the molecular mechanisms of this regulation, demonstrating that IMP-3 and its protein partners ILF3/NF90 and PTBP1 bind to the 3'UTRs of the cyclin mRNAs and protect them from the translational repression induced by miRNA-dependent recruitment of AGO2/GW182 complex in human cancer cells.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Deforzh E,Vargas TR,Kropp J,Vandamme M,Pinna G,Polesskaya Adoi
10.3892/ijo.2016.3750subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2578-2588issue
6eissn
1019-6439issn
1791-2423journal_volume
49pub_type
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