The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil.

abstract：:A new continuous cell line from a human malignant carcinoid of the small intestine (KRJ-I) was established. The cells showed morphological and immunocytochemical features of the tumor of origin and expressed estrogen receptors. The cells are growing as a suspension, forming multicellular aggregates and spheroids. Elec...

journal_title：International journal of oncology

authors： Pfragner R,Wirnsberger G,Niederle B,Behmel A,Rinner I,Mandl A,Wawrina F,Luo J,Adamiker D,Hoger H,Ingolic E,Schauenstein K

更新日期：1996-03-01 00:00:00

abstract：:Several lines of direct evidence show that gliomas express high levels of vascular endothelial growth factor (VEGF). VEGF can promote the growth of gliomas through angiogenesis. It is believed that gliomas originate in the brain tumor stem cells (BTSCs). However, the direct effect of VEGF on the biological behavior of...

journal_title：International journal of oncology

authors： Li Q,Qiao G,Ma J,Li Y

更新日期：2014-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training c...

journal_title：International journal of oncology

authors： Wang X,Liao X,Yu T,Gong Y,Zhang L,Huang J,Yang C,Han C,Yu L,Zhu G,Qin W,Liu Z,Zhou X,Liu J,Han Q,Peng T

更新日期：2019-10-01 00:00:00

abstract：:Understanding the link between chemoresistance and cancer progression may identify future targeted therapy for breast cancer. One of the mechanisms by which chemoresistance is attained in cancer cells is mediated through the expression of multidrug resistance proteins (MRPs). Acquiring drug resistance has been correla...

journal_title：International journal of oncology

authors： Thulasiraman P,Johnson AB

更新日期：2016-08-01 00:00:00

abstract：:Tumour cell surfaces possess a cell surface protease (GB), which can be recognised by a cytoplasmic inhibitor protein prepared from cultured tumour cells. This enzyme inhibitor complex has been shown to be reversibly dissociated by 10-(4)M sodium dodecyl sulphate. Sections of frozen tumour tissue were used to provide ...

journal_title：International journal of oncology

authors： Steven F,Griffin M,Blakey D

更新日期：1992-06-01 00:00:00

abstract：:The α6 integrin subunit (α6) has been implicated in cancer cell migration and in the progression of several malignancies, but its role in tumor angiogenesis is unclear. In mice, anti-α6 blocking antibodies reduce tumor angiogenesis, whereas Tie1-dependent α6 gene deletion enhances neovessel formation in melanoma and l...

journal_title：International journal of oncology

authors： Bouvard C,Segaoula Z,De Arcangelis A,Galy-Fauroux I,Mauge L,Fischer AM,Georges-Labouesse E,Helley D

更新日期：2014-11-01 00:00:00

abstract：:TGF-β-induced epithelial-mesenchymal transition (EMT) plays an important role in tumor progression. We assessed whether the TGF-β-induced EMT contributed to vasculogenic mimicry (VM) formation in glioma, we established an SHG44 cell line stably transfected with TGF-β cDNA loaded lentivirus. SB203580 was employed to in...

journal_title：International journal of oncology

authors： Ling G,Ji Q,Ye W,Ma D,Wang Y

更新日期：2016-12-01 00:00:00

abstract：:One hundred five patients with clinical stage T2-T4 transitional cell bladder carcinoma who completed either low-dose (20-26 Gy) or high dose (40-50 Gy) preoperative radiotherapy (RT) followed by cystectomy were reviewed. Five-year actuarial survival was 42%, 52%, and 17% for stages T2, T3, and T4, respectively. Five-...

journal_title：International journal of oncology

authors： Cox J,Greven K,Anscher M,Morgan T

更新日期：1992-10-01 00:00:00

abstract：:Recent studies show an increased incidence of head and neck cancers worldwide. The present study evaluated the trend in the incidence of head and neck cancers in England during 2002-2011. Data were extracted from the database of Office for National Statistics. The study population was categorised according to age, res...

journal_title：International journal of oncology

authors： McCarthy CE,Field JK,Rajlawat BP,Field AE,Marcus MW

更新日期：2015-07-01 00:00:00

abstract：:Sixty-four colorectal carcinomas were evaluated for allelic loss of chromosomes 17p and 5q, as well as point mutation of the p53 tumor suppressor gene. Allelic loss of chromosomes 5q and 17p were found to be weakly associated, whereas point mutation of the p53 gene was found to be more strongly associated with chromos...

journal_title：International journal of oncology

authors： Smith D,Khine K,Chan C,Goh H

更新日期：1994-09-01 00:00:00

abstract：:Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ a...

journal_title：International journal of oncology

authors： Sugihara AQ,Rolle CE,Lesniak MS

更新日期：2009-06-01 00:00:00

abstract：:To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% o...

journal_title：International journal of oncology

authors： Molendini L,Benassi MS,Magagnoli G,Merli M,Sollazzo MR,Ragazzini P,Gamberi G,Ferrari C,Balladelli A,Bacchini P,Picci P

更新日期：1998-05-01 00:00:00

abstract：:Tumor metastases are the ultimate target in cancer therapy. In epithelial malignancies, the expression of high-mobility-group A2 (HMGA2) is associated with disease progression and the epithelial-mesenchymal transition (EMT), which is involved in the metastatic process. The present study assessed the clinical and molec...

journal_title：International journal of oncology

authors： Lee J,Ha S,Jung CK,Lee HH

更新日期：2015-01-01 00:00:00

abstract：:The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...

journal_title：International journal of oncology

authors： Shimamoto R,Sawada T,Uchima Y,Inoue M,Kimura K,Yamashita Y,Yamada N,Nishihara T,Ohira M,Hirakawa K

更新日期：2004-06-01 00:00:00

abstract：:Evidence of circulating soluble DNA in blood-stream of cancer patients has emerged. Because the plasma DNA is largely derived from cancer cells, genetic analysis of plasma DNA is important to understand the molecular events occurred in cancer patient. Seven microsatellite markers in the soluble plasma DNA from patient...

journal_title：International journal of oncology

authors： Moriyama H,Matsubara N,Kanbara T,Mori M,Matsuoka J,Yoshino T,Takakura N,Shimizu K,Takaka N

更新日期：2002-11-01 00:00:00

abstract：:Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the progression and growth of pancreatic cancer using the simultaneous administration of agents that inhibit the function of both targets, should be considered. In the pres...

journal_title：International journal of oncology

authors： Ding N,Cui XX,Gao Z,Huang H,Wei X,Du Z,Lin Y,Shih WJ,Rabson AB,Conney AH,Hu C,Zheng X

更新日期：2014-06-01 00:00:00

abstract：:The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signal...

journal_title：International journal of oncology

authors： Hafsi S,Pezzino FM,Candido S,Ligresti G,Spandidos DA,Soua Z,McCubrey JA,Travali S,Libra M

更新日期：2012-03-01 00:00:00

abstract：:The objective of this study was to assess the toxicity and immunological response induced by autologous dendritic cells (DCs) pulsed with allogeneic tumor lysate in a pancreatic cancer patient. The lack of available tumor peptides in pancreatic cancer strongly supports the idea to use allogeneic tumor cells as a sourc...

journal_title：International journal of oncology

authors： Stift A,Friedl J,Dubsky P,Bachleitner-Hofmann T,Benkoe T,Brostjan C,Jakesz R,Gnant M

更新日期：2003-03-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

journal_title：International journal of oncology

authors： Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

更新日期：2005-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) are a family of mitogenic proteins involved in the regulation of cell growth and differentiation. The presence and role of the IGF system in oral mucosal epithelium is not clear but could influence our understanding of the pathogenesis of oral cancer. We characterised the express...

journal_title：International journal of oncology

authors： Brady G,Crean SJ,Naik P,Kapas S

更新日期：2007-10-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:Cytokine production in squamous cell carcinoma (SCC) of the head and neck may directly influence the clinical behavior of this aggressive neoplasm since cytokines act as autocrine/paracrine growth factors, as well as immunomodulators. In the present study, the cytokine profiles of 16 SCCs of the head and neck and matc...

journal_title：International journal of oncology

authors： Sabourin C,Wang Q,Mallery S,Nicholson R,Gopalakrishnan R,Lang J,Schuller D,Stoner G

更新日期：1996-01-01 00:00:00

abstract：:The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 was clearly demonstrated in two independent PLAG1 transgenic mouse founders, in which PLAG1 expression could be targeted to different tissues usin...

journal_title：International journal of oncology

authors： Declercq J,Van Dyck F,Van Damme B,Van de Ven WJ

更新日期：2008-05-01 00:00:00

abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

journal_title：International journal of oncology

authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

更新日期：1993-04-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...

journal_title：International journal of oncology

authors： Yin F,Liu X,Li D,Wang Q,Zhang W,Li L

更新日期：2013-04-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. ...

journal_title：International journal of oncology

authors： Kubo T,Sugita T,Shimose S,Nitta Y,Ikuta Y,Murakami T

更新日期：2000-08-01 00:00:00

abstract：:In this study we examined the levels of IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha and sIL-2R in the sera and culture supernatants of PHA-stimulated lymphocytes from a series of 90 cancer patients. The expression of the IL-2R p55 chain (alpha subunit) on PHA-stimulated lymphocytes was also evaluated together with th...

journal_title：International journal of oncology

authors： Mantovani G,Maccio A,Esu S,Lai P,Ghiani M,Turnu E,Contu G,Volpe A,Delgiacco G

更新日期：1994-12-01 00:00:00