Abstract:
:Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ and Treg infiltration are significantly increased throughout the time of metastatic tumor progression. These findings were recapitulated in human CNS tumor samples of metastatic melanoma and non-small cell lung carcinoma. Collectively, these data support investigating immunotherapeutic strategies targeting Treg in metastatic CNS tumors.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Sugihara AQ,Rolle CE,Lesniak MSdoi
10.3892/ijo_00000282subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1533-40issue
6eissn
1019-6439issn
1791-2423journal_volume
34pub_type
杂志文章abstract::The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2890
更新日期:2015-05-01 00:00:00
abstract::Radioiodinated meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used in management of neuroendocrine tumors. Recent studies reveal that distribution of radioiodinated MIBG in animals depends on the specific activity of this radiopharmaceutical. In order to clarify the effect of specific activit...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.4.815
更新日期:1997-04-01 00:00:00
abstract::A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.1.101
更新日期:1998-07-01 00:00:00
abstract::Transforming growth factor-β receptor II (TGFBR2) is implicated in various types of cancer. Most molecules involved in the TGF-β pathway can be degraded by one or more microRNAs (miRNAs). In the present study, we show that miRNA plays an important role in downregulating TGFBR2 expression in Ewing's sarcoma (ES) cells....
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4155
更新日期:2017-12-01 00:00:00
abstract::Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members. MG-160 is an intri...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and is highly resistant to conventional cancer therapy. A better understanding of the regulatory mechanisms which control the growth of this deadly malignancy are urgently needed to develop more effective cancer intervention strategies. Recent studies h...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::The last decade has brought increased awareness to prostate cancer as a significant health problem. Prostate cancer is very heterogeneous in its etiology and progression, but androgen signaling appears to be a common key element in its development and progression. Blocking of androgen signaling results in a decrease i...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.23.4.1095
更新日期:2003-10-01 00:00:00
abstract::Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3006
更新日期:2015-07-01 00:00:00
abstract::Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000431
更新日期:2009-11-01 00:00:00
abstract::Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2004
更新日期:2013-09-01 00:00:00
abstract::Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been frequently administered in colon cancer patients, low response rates to these single drug therapies were reported. It is therefore imperative to search for new targeted combination therapies t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000465
更新日期:2009-12-01 00:00:00
abstract::High levels of mitotic progression-associated PLK1 and stress-associated HSF1 have been observed in various human cancers. In the present study, we investigated the effects of PLK1 and HSF1 knockdown on the proliferation of oral cancer cells using small interfering RNA. In human oral squamous cell carcinoma (SCC) tiss...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000564
更新日期:2010-04-01 00:00:00
abstract::Idarubicin (IDA) is a 4-demethoxy-anthracycline analogue of daunorubicin (DNR). IDA has been recognized as a potent anti-leukemic agent. However, the molecular mechanism of IDA-induced cell death remains unclear. In the present study, we investigated the activity of IDA to induce apoptosis in human leukemia HL-60 and ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1283
更新日期:2012-04-01 00:00:00
abstract::We have previously isolated a drug-resistant, [PC3(R)], variant of human prostate PC3 cell line, which showed significant resistance (>10-fold) to adriamycin. No known mechanisms of drug resistance were found; however, resistant cells expressed more bcl2, c-myc, and ms oncogenes compared to the sensitive cells. In thi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.4.819
更新日期:1997-10-01 00:00:00
abstract::NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.12.6.1237
更新日期:1998-06-01 00:00:00
abstract::Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non‑synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4915
更新日期:2020-01-01 00:00:00
abstract::We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive to cetuximab. In the present study, we demonstrate di...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3215
更新日期:2015-12-01 00:00:00
abstract::Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1133
更新日期:2011-11-01 00:00:00
abstract::The Stockholm Central Railway Station in Sweden was investigated for public radiofrequency (RF) radiation exposure. The exposimeter EME Spy 200 was used to collect the RF exposure data across the railway station. The exposimeter covers 20 different radiofrequency bands from 88 to 5,850 MHz. In total 1,669 data points ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3657
更新日期:2016-10-01 00:00:00
abstract::It has previously been suggested that some tumours may elaborate substances which can suppress the functional activity of lymphokine activated killer (LAK) cells. We have investigated the effects of secreted products from the colorectal cancer cell line LoVo on the pattern of expression of T lymphocyte subsets and nat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.763
更新日期:1993-10-01 00:00:00
abstract::In the present study, a series of seven synthetic croma-kalim analogues were prepared and evaluated for cytotoxic effect on human cervical carcinoma HeLa cells using WST-8 assay. A preliminary screening of these cromakalim analogues showed that 1-[(3S,4R)-4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy- 2,2-dimethylchr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1153
更新日期:2011-12-01 00:00:00
abstract::Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4918
更新日期:2020-01-01 00:00:00
abstract::The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1086
更新日期:2011-10-01 00:00:00
abstract::The poor prognosis of Ewing's sarcoma (EWS), together with its high lethal recurrence rate and the side‑effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side‑effects. The oncogenic chimeric protein EWS/FLI1 is the key malignancy driver in mo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2016
更新日期:2013-09-01 00:00:00
abstract::The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-randomized trial in h...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:10.3892/ijo.16.6.1227
更新日期:2000-06-01 00:00:00
abstract::Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnost...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.5.1063
更新日期:2001-11-01 00:00:00
abstract::Meningiomas are the most commonly occurring tumors of the central nervous system including the brain and spinal cord. Malignant meningiomas are highly aggressive and frequently recur after surgical resection of the tumor. Our previous studies have reported that urokinase plasminogen activator receptor (uPAR) and matri...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Retroviral reverse transcriptase (RT) plays a definite role in retroviral life cycle and is essential for the process of retrotransposition. We investigated the RNA expression of endogenous reverse transcriptases (enRTs) in the NIH3T3 mouse genome using, as a probe, a mixture of RT-PCR generated reverse transcriptase ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.3.609
更新日期:1997-03-01 00:00:00