Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas.

abstract：:The effects of retinoic acid (RA) and its analogs, all-trans RA, 9-cis RA and 13-cis RA, were investigated in human breast cancer MCF-7 cells and immortalized breast epithelial cell line MCF-10A. RA inhibited the telomerase activity of MCF-7 cells in a wide range of concentrations. RA at 10 microM also inhibited the g...

journal_title：International journal of oncology

authors： Choi SH,Kang HK,Im EO,Kim YJ,Bae YT,Choi YH,Lee KH,Chung HY,Chang HK,Kim ND

更新日期：2000-11-01 00:00:00

abstract：:Gastric carcinoma is the most common cancer and the second most common cause of cancer-related death in Korea. Many studies have been reported regarding prognostic factors. Among the category I prognostic factors of gastric carcinoma, lymph node metastasis (nodal status) is considered to be the strongest prognostic fa...

journal_title：International journal of oncology

authors： Lee SY,Hwang I,Park YS,Gardner J,Ro JY

更新日期：2010-06-01 00:00:00

abstract：:EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II), progresses tumor invasion and metastasis by increasing the production of matrix metalloproteinase (MMP) in peritumoral stoma cel...

journal_title：International journal of oncology

authors： Sato T,Watanabe M,Hashimoto K,Ota T,Akimoto N,Imada K,Nomizu M,Ito A

更新日期：2012-01-01 00:00:00

abstract：:Malignant gliomas are treated by combining surgery and radiation with chemotherapy. Cure is rare and utilizing information arising from our improved understanding of brain tumor biology may be of value. Interferon alpha (IFNalpha) treatment as restorative immunotherapy has been utilized in malignant gliomas in the pas...

journal_title：International journal of oncology

authors： Olson JJ,James CD,Lawson D,Hunter S,Tang G,Billingsley J

更新日期：2004-08-01 00:00:00

abstract：:The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...

journal_title：International journal of oncology

authors： Lee WS,Park YL,Kim N,Oh HH,Son DJ,Kim MY,Oak CY,Chung CY,Park HC,Kim JS,Myung DS,Cho SB,Joo YE

更新日期：2015-05-01 00:00:00

abstract：:CDC28 protein kinase regulatory subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have investigated its involvement in gastric cancer. In this study, we focused on the clinical and biological significance of CKS2 over-expression in gastric...

journal_title：International journal of oncology

authors： Tanaka F,Matsuzaki S,Mimori K,Kita Y,Inoue H,Mori M

更新日期：2011-08-01 00:00:00

abstract：:This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...

journal_title：International journal of oncology

authors： Van den Neste E,Cardoen S,Offner F,Bontemps F

更新日期：2005-10-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making ...

journal_title：International journal of oncology

authors： Park JG,Yuan Y

更新日期：1998-04-01 00:00:00

abstract：:Chemotherapeutic treatment with combinations of drugs is front-line therapy for many types of cancer. Combining drugs that target different signaling pathways often lessens adverse side-effects while increasing the efficacy of treatment and reducing patient morbidity. Histone deacetylase (HDAC) inhibitors represent a ...

journal_title：International journal of oncology

authors： Sato T,Suzuki M,Sato Y,Echigo S,Rikiishi H

更新日期：2006-05-01 00:00:00

abstract：:A serum-specific protein 'fingerprint' model was established which is capable of evaluating the effect of chemotherapy (gemcitabine) of pancreatic adenocarcinoma. We used SELDI-TOF-MS coupled with CM10 chips and bioinformatics tools to analyze a total of 45 mouse serum samples from three groups: the healthy control gr...

journal_title：International journal of oncology

authors： Cao L,Wang L,Wang G,Liu D,Yu J,Que R,Xie D

更新日期：2010-12-01 00:00:00

abstract：:Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most impor...

journal_title：International journal of oncology

authors： Kawamoto S,Moriwaki K,Nakagawa T,Terao M,Shinzaki S,Yamane-Ohnuki N,Satoh M,Mehta AS,Block TM,Miyoshi E

更新日期：2011-07-01 00:00:00

abstract：:Paeonol, a potent antioxidant isolated from cortex moutan, possesses athero‑protective activity, yet the detailed mechanisms are not fully investigated. This study was conducted to explore the role of paeonol and its underlying mechanisms in RAW264.7 macrophages and apolipoprotein E‑deficient (ApoE(‑/‑)) mice. Paeonol...

journal_title：International journal of oncology

authors： Li X,Zhou Y,Yu C,Yang H,Zhang C,Ye Y,Xiao S

更新日期：2015-02-01 00:00:00

abstract：:Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...

journal_title：International journal of oncology

authors： Hardell L,Fredrikson M,Axelson O

更新日期：1996-03-01 00:00:00

abstract：:Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the contribution of endogenous CCK to tumor growth is unknown. The purpose of this study was to evaluate the role of endogenous CCK on autocrine growth of pancreatic cancer...

journal_title：International journal of oncology

authors： Matters GL,McGovern C,Harms JF,Markovic K,Anson K,Jayakumar C,Martenis M,Awad C,Smith JP

更新日期：2011-03-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue tumors arising sporadically although more frequently in patients with Neurofibromatosis type 1. Prognosis remains dismal as chemo- and radiotherapy have not been shown to be successful. The heparin-binding growth factor, Midkine (MK), is impl...

journal_title：International journal of oncology

authors： Friedrich C,Holtkamp N,Cinatl J Jr,Sakuma S,Mautner VF,Wellman S,Michaelis M,Henze G,Kurtz A,Driever PH

更新日期：2005-11-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), are characterized by mutations of the KIT or platelet-derived growth factor receptor-α gene and the constitutive expression of Kit, which is currently being studied as a potential therapeutic target. In this study, we addressed the question of whether the microRNA (miRNA) 221/2...

journal_title：International journal of oncology

authors： Koelz M,Lense J,Wrba F,Scheffler M,Dienes HP,Odenthal M

更新日期：2011-02-01 00:00:00

abstract：:Collagen type I is an abundant component of the extracellular matrix and due to its longevity, constitutes a prominent target of non-enzymatic post-translational in vivo modifications such as carbamylation and glycation. These protein modifications involved in aging, renal diseases and diabetes, are linked to elevated...

journal_title：International journal of oncology

authors： Said G,Guilbert M,Millerot-Serrurot E,Van Gulick L,Terryn C,Garnotel R,Jeannesson P

更新日期：2012-06-01 00:00:00

abstract：:After the publication of the article, the authors noted that they had made the following errors. In Fig. 5B, total PDK1 is incorrect in the published paper. The corrected version of Fig. 5B is shown below. Also in Fig. 6B, the DMSO-treated group and the brassinin (400 µM)-treated group are incorrect, and the corrected...

journal_title：International journal of oncology

authors： Izutani Y,Yogosawa S,Sowa Y,Sakai T

更新日期：2016-03-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:Low concentrations of monoclonal antibodies (mAb) specific for the CD3 component of the T cell receptor complex (TcR) may be both immunosuppressive or potent activators of T cell function in vitro depending upon the experimental situation. The anti-CD3 mAb OKT3 is imnmunosuppressive at high doses (5 mg/day for 10 to 1...

journal_title：International journal of oncology

authors： Hollingworth J,Catterick R,Horsburgh T,Veitch P,Bell P

更新日期：1994-09-01 00:00:00

abstract：:Polymerase chain reaction (PCR) has been reported as one of the most efficient techniques to detect hepatitis C virus (HCV) RNA. The determination of the specificity of PCR products is usually based on 'nested' PCR, Southern blotting and hybridization of the amplified DNA to radioactive oligonucleotide probes recogniz...

journal_title：International journal of oncology

authors： Bianchi N,Mischiati C,Feriotto G,Gambari R

更新日期：1994-04-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated-antigens (TAA), of 66 kDa and 51 kDa, could promote suppression by anticancer drugs of chemically-induced mammary tumorigenesis. Dimethylbenzanthracene (DMBA, 10 mg/rat, twice) was used to induce mammary tumors. Then, for nine more weeks, the preparation of TAA ...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2001-08-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with translocation t(4;11) is a high-risk leukemia found in 60-85% of infants with ALL and is often refractory to conventional chemotherapeutics after relapse. To evaluate the efficacy of dietary resveratrol in vivo, 5-week-old NOD.CB17-Prkdcscid/J mice were fed a control diet or a d...

journal_title：International journal of oncology

authors： Zunino SJ,Storms DH,Newman JW,Pedersen TL,Keen CL,Ducore JM

更新日期：2012-12-01 00:00:00

abstract：:Stromal cells isolated from lymph nodes of adult T-cell leukemia/lymphoma (ATL) patients were cultured. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. The rate of human T lymphotropic virus type...

journal_title：International journal of oncology

authors： Joh T,Yamada Y,Seto M,Nakamura S,Ohmoto Y,Kamihira S,Tomonaga M,Shiku H

更新日期：1996-10-01 00:00:00

abstract：:In this study tumor-specific CTL effector and memory responses were analyzed in normal mice, in tumor bearing mice and in animals treated by active specific immunotherapy (ASI) with an autologous virus modified tumor vaccine. In the well defined DBA/2 mouse lymphoma model ESb, the tumor specific CTL response requires ...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：1999-08-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most unfavorable prognostic tumor, and immediate growth and distant metastasis are important factors associated with the poor prognosis of patients with this disease. Standard and variant isoforms of CD44 are associated with tumor growth, metastasis, and epithelial-mesenchymal tr...

journal_title：International journal of oncology

authors： Miwa T,Nagata T,Kojima H,Sekine S,Okumura T

更新日期：2017-09-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...

journal_title：International journal of oncology

authors： Jiao F,Hu H,Yuan C,Jin Z,Guo Z,Wang L,Wang L

更新日期：2014-10-01 00:00:00

abstract：:In normal human somatic cells, gradual shortening of telomeres may activate the complex cascade of molecular events known as cellular senescence. Experimental evidence from our laboratory suggests that cellular mortality is regulated by two separate mechanisms that we have termed mortality stage 1 (M1) and mortality s...

journal_title：International journal of oncology

authors： Shay J,Wright W,Werbin H

更新日期：1993-10-01 00:00:00

abstract：:We previously developed a new microscopic observation system that enables time-lapse quantitative analysis of apoptosis and necrosis. With this system we quantitatively analyzed adriamycin (ADR)-induced cell death using manganese superoxide dismutase (MnSOD)- and wild-type p53-gene transfectants on SaOS(2), a p53-defi...

journal_title：International journal of oncology

authors： Wang Y,Kuroda M,Gao XS,Asaumi J,Shibuya K,Kawasaki S,Akaki S,St Clair D,Hiraki Y,Kanazawa S

更新日期：2005-05-01 00:00:00