Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency.

abstract：:In the present study, the cc‑006cpm8 novel colon cell line was established from a sample of right colorectal adenocarcinoma obtained from a woman with liver metastasis. It was possible to culture this cell line for ≥100 passages in vitro with vigorous growth. Morphologically, the cells grew as several layers with tigh...

journal_title：International journal of oncology

authors： Chu X,Xue Y,Huo X,Wei J,Chen Y,Han R,Chen H,Su X,Zhang H,Gong Y,Chen J

更新日期：2019-07-01 00:00:00

abstract：:Trophoblasts are derived from the normal placenta, and they infiltrate into the endometrium and the maternal blood vessels under strict control but, unlike malignant cells, never metastasize. To understand the proliferative characteristics of trophoblasts and its related disorders, we assessed telomerase activity in c...

journal_title：International journal of oncology

authors： Nishi H,Yahata N,Ohyashiki K,Isaka K,Shiraishi K,Ohyashiki JH,Toyama K,Takayama M

更新日期：1998-01-01 00:00:00

abstract：:Thirty-three adult patients with anaplastic astrocytoma or glioblastoma multiforme, verified between 1990 and 1997, received postoperative intra-arterial ACNU chemotherapy and irradiation. Since our previous strategies to malignant gliomas had included intra-venous ACNU, the purpose of the present study is to evaluate...

journal_title：International journal of oncology

authors： Hirano Y,Mineura K,Mizoi K,Tomura N

更新日期：1998-09-01 00:00:00

abstract：:After the publication of the article, the authors have realized that the affiliation presented for the joint co‑author listed on the paper (Jian‑Ren Tu) was incorrect. The correct author list (and affiliations) should therefore have been published as follows: Yu‑Hua Xu1*, Jian‑Ren Tu2*, Tian‑Tian Zhao3, Shi‑Guang Xie3...

journal_title：International journal of oncology

authors： Xu YH,Tu JR,Zhao TT,Xie SG,Tang SB

更新日期：2019-07-01 00:00:00

abstract：:The tumour suppressor gene hypermethylated in cancer 1 (HIC1) is a transcriptional repressor, which functionally cooperates with p53. Loss of HIC1 function is associated with the development of various tumor entities. The aim of this study was to elucidate the relevance of CpG islan...

journal_title：International journal of oncology

authors： Eggers H,Steffens S,Grosshennig A,Becker JU,Hennenlotter J,Stenzl A,Merseburger AS,Kuczyk MA,Serth J

更新日期：2012-05-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by extensive angiogenesis that is mostly orchestrated by the hypoxia inducible factor HIF-1. Deregulation of HIF-1 is believed to contribute to cancer initiation and progression. However, instances have been described in which loss of HIF-1 leads to more aggressive tumors...

journal_title：International journal of oncology

authors： Fiorenzo P,Mongiardi MP,Dimitri D,Cozzolino M,Ferri A,Montano N,Trevisi G,Maira G,Battistini L,Falchetti ML,Levi A,Pallini R

更新日期：2010-04-01 00:00:00

abstract：:Overexpression of inducible nitric oxide synthase (iNOS) and the resultant overproduction of NO has been implicated in neuronal inflammatory diseases. Leptomycin B (LMB), a metabolite of Streptomyces, has been identified as a specific inhibitor of CRM1 nuclear export receptor. In this study, we evaluated the effect of...

journal_title：International journal of oncology

authors： Jang BC,Sung SH,Park JG,Park JW,Suh MH,Choi IH,Yoshida M,Yoo SK,Suh SI

更新日期：2006-12-01 00:00:00

abstract：:Selectivity of the anticancer agent PB-100 for malignant cells, already demonstrated using cell growth and viability evaluation, is now confirmed by microscopic observations. PB-100 is easily detected inside cells by its yellow color under visible light and by its blue fluorescence; it may be measured in isolated nucl...

journal_title：International journal of oncology

authors： Beljanski M,Crochet S

更新日期：1995-07-01 00:00:00

abstract：:Pemetrexed (PEM) is a novel, multitargeted, antifolate, antineoplastic agent for the treatment of non-small cell lung cancer and malignant pleural mesothelioma. Additional effects of nitric oxide (NO) donors on the chemosensitivity of cancers have been reported. However, the effects of an NO donor on PEM-induced cytot...

journal_title：International journal of oncology

authors： Nagai H,Yasuda H,Hatachi Y,Xue D,Sasaki T,Yamaya M,Sakamori Y,Togashi Y,Masago K,Ito I,Kim YH,Mio T,Mishima M

更新日期：2012-07-01 00:00:00

abstract：:Cutaneous infantile hemangioma progresses through proliferation and involution phases. Since treatment with interferon, a negative regulator of angiogenesis, accelerates the involution phase, we hypothesized that cutaneous infantile hemangioma is associated with an imbalance between endogenous positive and negative re...

journal_title：International journal of oncology

authors： Bielenberg DR,Bucana CD,Sanchez R,Mulliken JB,Folkman J,Fidler IJ

更新日期：1999-03-01 00:00:00

abstract：:Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2021-01-11 00:00:00

abstract：:Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome. We have previously reported that inhibitors of histone deacetylas...

journal_title：International journal of oncology

authors： Torres J,Regan PL,Edo R,Leonhardt P,Jeng EI,Rappaport EF,Ikegaki N,Tang XX

更新日期：2010-10-01 00:00:00

abstract：:VSELs are a population of rare Oct-4+CXCR4+ CD133+lin-CD45- cells that are deposited during early embryogenesis in developing organs/tissues as a reserve population of pluripotent stem cells for regeneration. We reported recently that they are mobilized into peripheral blood during acute myocardial infarction (AMI) in...

journal_title：International journal of oncology

authors： Wojakowski W,Tendera M,Kucia M,Zuba-Surma E,Milewski K,Wallace-Bradley D,Kazmierski M,Buszman P,Hrycek E,Cybulski W,Kaluza G,Wieczorek P,Ratajczak J,Ratajczak MZ

更新日期：2010-08-01 00:00:00

abstract：:Lung cancer is a prevalent disease and is one of the leading causes of mortality worldwide. Despite the development of various anticancer drugs, the prognosis of lung cancer is relatively poor. Metastasis of lung cancer, as well as chemoresistance, is associated with a high mortality rate for patients with lung cancer...

journal_title：International journal of oncology

authors： Chiu YH,Hsu SH,Hsu HW,Huang KC,Liu W,Wu CY,Huang WP,Chen JY,Chen BH,Chiu CC

更新日期：2018-11-01 00:00:00

abstract：:Fluoroquinolone antibiotics induce cytotoxicity in various cancer cell lines and may therefore represent a potentially important source of novel anticancer agents. The aim of the present study was to examine the effect of ciprofloxacin on the viability, redox balance, apoptosis, expression of p53, Bax and Bcl-2, cell ...

journal_title：International journal of oncology

authors： Beberok A,Wrześniok D,Rok J,Rzepka Z,Respondek M,Buszman E

更新日期：2018-05-01 00:00:00

abstract：:Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). Identification of methylated genes is necessary to improve our understanding of the pathogenesis of HCC and develop novel biomarkers and therapeutic targe...

journal_title：International journal of oncology

authors： Tanaka Y,Kanda M,Sugimoto H,Shimizu D,Sueoka S,Takami H,Ezaka K,Hashimoto R,Okamura Y,Iwata N,Tanaka C,Yamada S,Fujii T,Nakayama G,Koike M,Nomoto S,Fujiwara M,Kodera Y

更新日期：2015-01-01 00:00:00

abstract：:Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...

journal_title：International journal of oncology

authors： Dittmer A,Lange T,Leyh B,Dittmer J

更新日期：2020-01-01 00:00:00

abstract：:Simultaneous resistance of cancer cells to multiple cytotoxic drugs, multidrug resistance (MDR), is the major limitation to the successful chemotherapeutic treatment of disseminated neoplasms. The 'classical' MDR phenotype is conferred by MDR1/P-glycoprotein (MDR1/P-gp) that is expressed in almost 50% of human cancers...

journal_title：International journal of oncology

authors： Kaszubiak A,Holm PS,Lage H

更新日期：2007-08-01 00:00:00

abstract：:Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerob...

journal_title：International journal of oncology

authors： Xu H,Zeng Y,Liu L,Gao Q,Jin S,Lan Q,Lai W,Luo X,Wu H,Huang Y,Chu Z

更新日期：2017-10-01 00:00:00

abstract：:Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown o...

journal_title：International journal of oncology

authors： Sang Y,Sun L,Wu Y,Yuan W,Liu Y,Li SW

更新日期：2019-03-01 00:00:00

abstract：:While the effects of single growth factors on endothelial cells (ECs) have been extensively studied, the importance of induction of growth factors such as PDGF-BB (platelet derived growth factor) in ECs and its impact on tumor cell functions are only partly understood. Human umbilical vein endothelial cells (HUVECs) w...

journal_title：International journal of oncology

authors： Reinmuth N,Rensinghoff S,Raedel M,Fehrmann N,Schwöppe C,Kessler T,Bisping G,Hilberg F,Roth GJ,Berdel W,Thomas M,Mesters RM

更新日期：2007-09-01 00:00:00

abstract：:Activation of the Wingless (Wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. Depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the s...

journal_title：International journal of oncology

authors： Teiten MH,Gaascht F,Cronauer M,Henry E,Dicato M,Diederich M

更新日期：2011-03-01 00:00:00

abstract：:Conceptually, dendritic cells (DCs) take up and process exogenous antigens that are presented on MHC (major histocompatibility complex) class II molecules to stimulate CD4+ T cells, and present endogenously-produced proteins to CD8+ T cells through an MHC class I-dependent pathway. In this study, we compared the antit...

journal_title：International journal of oncology

authors： Lacave R,Masurier C,Guigon M,Lemoine FM,Klatzmann D,Colombo BM

更新日期：2003-12-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:Glioma is the most prevalent and fatal primary tumor of the central nervous system in adults, while the development of effective therapeutic strategies in clinical practice remain a challenge. Nucleotide-binding domain leucine-rich family pyrin-containing 3 (NLRP3) has been reported to be associated with tumorigenesis...

journal_title：International journal of oncology

authors： Yin XF,Zhang Q,Chen ZY,Wang HF,Li X,Wang HX,Li HX,Kang CM,Chu S,Li KF,Li Y,Qiu YR

更新日期：2018-09-01 00:00:00

abstract：:The RON receptor tyrosine kinase and its ligand macrophage stimulating protein (MSP) play a role in epithelial tumorigenesis. We report here a novel RON variant that antagonizes the RON-MSP pathway in various cancer cells. The variant is an 85 kDa soluble protein from an mRNA transcript with an insertion of 49 nucleot...

journal_title：International journal of oncology

authors： Ma Q,Zhang K,Yao HP,Zhou YQ,Padhye S,Wang MH

更新日期：2010-06-01 00:00:00

abstract：:Radioiodinated meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used in management of neuroendocrine tumors. Recent studies reveal that distribution of radioiodinated MIBG in animals depends on the specific activity of this radiopharmaceutical. In order to clarify the effect of specific activit...

journal_title：International journal of oncology

authors： Farahati J,Lassmann M,Scheubeck M,Bier D,Hanscheid H,Schelper L,Grelle I,Biko J,Werner E,Graefe K,Reiners C

更新日期：1997-04-01 00:00:00

abstract：:New aromatase inhibitors are an exciting treatment option for postmenopausal women with hormone sensitive breast cancer. They have been shown to reduce tumors in a significant number of patients, and exhibit definite antitumor activity at a relatively low daily dose, and are highly potent, highly selective, and well-t...

journal_title：International journal of oncology

authors： Crucitta E,Lorusso V,Attolico M,Sambiasi D,Mazzei A,De Lena M

更新日期：2000-11-01 00:00:00

abstract：:We investigated the relationship between cell growth and differentiation and COX-2 expression in oral squamous cell carcinoma (SCC) in vitro and in vivo. Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and in...

journal_title：International journal of oncology

authors： Kuroda J,Urade M,Kishimoto H,Noguchi K,Hashitani S,Sakurai K,Nishimura N,Hashimoto-Tamaoki T

更新日期：2005-02-01 00:00:00

abstract：:Multiple drug resistance is reported to be a major obstacle in treatment of osteosarcoma (OS). Research has demonstrated that small subsets of cells called cancer stem cells (CSCs) are responsible for multiple drug resistance. CSCs are potential targets for reversing chemoresistance. In the present study, we compared ...

journal_title：International journal of oncology

authors： Shang D,Wu J,Guo L,Xu Y,Liu L,Lu J

更新日期：2017-05-01 00:00:00