Overcoming the classical multidrug resistance phenotype by adenoviral delivery of anti-MDR1 short hairpin RNAs and ribozymes.

abstract：:PDZ-domain protein GIPC1/GIPC interacts with GTPase-activating protein RGS-GAIP, TGFbeta type III receptor, and integrin alpha6A subunit. Kermit, a Xenopus orthologue of human GIPC1, interacts with some class of WNT receptor. In this study, we identified a novel GIPC1-related gene in human genome by using bioinformati...

journal_title：International journal of oncology

authors： Kirikoshi H,Katoh M

更新日期：2002-03-01 00:00:00

abstract：:Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous ad...

journal_title：International journal of oncology

authors： Tsukagoshi S,Saga Y,Suzuki N,Fujioka A,Nakagawa F,Fukushima M,Suzuki M

更新日期：2003-05-01 00:00:00

abstract：:Angiogenesis is increased in various human cancers, including head and neck squamous cell carcinoma (HNSCC), and correlates with tumor progression and metastasis. Vascular endothelial growth factor (VEGF) has been shown to be a key regulator of angiogenesis. We determined whether VEGF antisense oligonucleotide treatme...

journal_title：International journal of oncology

authors： Riedel F,Götte K,Li M,Hörmann K,Grandis JR

更新日期：2003-09-01 00:00:00

abstract：:Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases re...

journal_title：International journal of oncology

authors： Dong Z,Yang J,Li L,Tan L,Shi P,Zhang J,Zhong X,Ge L,Wu Z,Cui H

更新日期：2020-03-01 00:00:00

abstract：:Endosialin emerged recently as a potential therapeutic target for sarcoma. Since some sarcoma subtypes, such as Ewing's sarcoma, show characteristics of neuroendocrine differentiation, we wondered whether cancers with neuro-endocrine properties and/or neuroectodermal origin, such as neuroblastoma, small cell lung canc...

journal_title：International journal of oncology

authors： Rouleau C,Smale R,Sancho J,Fu YS,Kurtzberg L,Weber W,Kruger A,Jones C,Roth S,Bormann C,Dunham S,Krumbholz R,Curiel M,Wallar G,Mascarello J,Campos-Rivera J,Horten B,Schmid S,Miller G,Teicher BA

更新日期：2011-10-01 00:00:00

abstract：:The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...

journal_title：International journal of oncology

authors： Seliger B,Bock M,Ritz U,Huber C

更新日期：2002-02-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have realized that the images presented in Fig. 1A were selected erroneously (essentially, the images for group 'AdBMP9 +++' were chosen to represent the group 'AdGFP'). A corrected version of Fig. 1, including the correct data for the experiments depicte...

journal_title：International journal of oncology

authors： Wu N,Li R,Meng Z,Nie M,Chen Q,He B,Deng Z,Yin L

更新日期：2019-08-01 00:00:00

abstract：:The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of ma...

journal_title：International journal of oncology

authors： Pankratova S,Nielsen BN,Shiraishi T,Nielsen PE

更新日期：2010-01-01 00:00:00

abstract：:Most cancer cells trigger thrombin generation (TG) to various extent. In the present study, we dissected the mechanisms responsible for the procoagulant activity of pancreatic adenocarcinoma cells (BXPC3), a highly thrombogenic cancer type, and breast cancer cells (MCF7), a less thombogenic tumor type. TG of normal pl...

journal_title：International journal of oncology

authors： Rousseau A,Larsen AK,Van Dreden P,Sabbah M,Elalamy I,Gerotziafas GT

更新日期：2017-12-01 00:00:00

abstract：:Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 part...

journal_title：International journal of oncology

authors： Tomirotti M,Bernardo G,Epifani C,Biasioli R,Franchi R,Mensi F,Carnaghi P,Schieppati G,Scanni A

更新日期：1993-08-01 00:00:00

abstract：:Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...

journal_title：International journal of oncology

authors： Weber R,Meister M,Muley T,Thomas M,Sültmann H,Warth A,Winter H,Herth FJF,Schneider MA

更新日期：2019-02-01 00:00:00

abstract：:Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can als...

journal_title：International journal of oncology

authors： Matsubara H,Maeda T,Gunji Y,Koide Y,Asano T,Ochiai T,Sakiyama S,Tagawa M

更新日期：2001-04-01 00:00:00

abstract：:Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon alpha (IFN-alpha) as a single agent or combined with standard chemo-therapy has been shown to inhibit various tumors, but the effect of combination anti-angiog...

journal_title：International journal of oncology

authors： Son MJ,Song HS,Kim MH,Kim JT,Kang CM,Jeon JW,Park SY,Kim YJ,Groves MD,Park K,Kim JH,Nam DH

更新日期：2006-06-01 00:00:00

abstract：:Optimal conditions have been defined to grow primary cultures of malignant melanoma suitable for in vitro pharmacological studies. A feasibility of primary cultures was observed in 60% of 62 clinical melanoma lymph node metastases. The neoplastic nature of the cells grown in culture, as assessed by the highly specific...

journal_title：International journal of oncology

authors： Villa R,Zaffaroni N,Orlandi L,Costa A,Veronese S,Vaglini M,Silvestrini R

更新日期：1992-11-01 00:00:00

abstract：:A precise diagnosis of peritoneal dissemination is necessary to determine the appropriate treatment strategy for colorectal cancer. However, small peritoneal dissemination is difficult to diagnose. 5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism. The administration of 5-ALA to cancer pati...

journal_title：International journal of oncology

authors： Kondo Y,Murayama Y,Konishi H,Morimura R,Komatsu S,Shiozaki A,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Takahashi K,Inoue K,Nakajima M,Otsuji E

更新日期：2014-07-01 00:00:00

abstract：:Serial analysis of gene expression (SAGE) is a sequence-based tool that enables quantitative study of comprehensive gene expression profiles. In this study, we generated a SAGE library of hepatitis B virus (HBV)-associated small hepatocellular carcinoma (HCC) and compared it with libraries of normal liver and other or...

journal_title：International journal of oncology

authors： Kim JW,Lee SH,Park YS,Jeong SH,Kim N,Lee DH,Lee HS

更新日期：2009-07-01 00:00:00

abstract：:Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with liver metastases are candidates for potentially curative surgical resection. The treatment of patients with unresectable liver tumors is a major clinical probl...

journal_title：International journal of oncology

authors： Cai SR,Garbow JR,Culverhouse R,Church RD,Zhang W,Shannon WD,McLeod HL

更新日期：2005-07-01 00:00:00

abstract：:Tumour cell surfaces possess a cell surface protease (GB), which can be recognised by a cytoplasmic inhibitor protein prepared from cultured tumour cells. This enzyme inhibitor complex has been shown to be reversibly dissociated by 10-(4)M sodium dodecyl sulphate. Sections of frozen tumour tissue were used to provide ...

journal_title：International journal of oncology

authors： Steven F,Griffin M,Blakey D

更新日期：1992-06-01 00:00:00

abstract：:We have previously shown that the combination of allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) using CD4+ cell-depleted spleen cells is effective in suppressing tumor growth, but that this does not induce graft-versus-host disease (GVHD) in mice. In this report,...

journal_title：International journal of oncology

authors： Mukaide H,Adachi Y,Koike-Kiriyama N,Suzuki Y,Minamino K,Iwasaki M,Tsuda M,Nakano K,Koike Y,Shigematsu A,Kamiyama Y,Ikehara S

更新日期：2007-06-01 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for human breast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, is a well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. I...

journal_title：International journal of oncology

authors： Huynh H,Beamer W,Pollak M,Chan TW

更新日期：2000-02-01 00:00:00

abstract：:Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. F...

journal_title：International journal of oncology

authors： Takeda K,Tomimori K,Kimura R,Ishikawa C,Nowling TK,Mori N

更新日期：2012-01-01 00:00:00

abstract：:A herbal preparation denoted PC SPES(R) is available in 'natural food' or 'health food' stores in the United States. This mixture (patent pending, US Serial number 08/697,920) consists of extracts from 8 different herbs, 7 originating from China and one from America, and is sold as a dietary supplement. Although sever...

journal_title：International journal of oncology

authors： Halicka H,Ardelt B,Juan G,Mittelman A,Chen S,Traganos F,Darzynkiewicz Z

更新日期：1997-09-01 00:00:00

abstract：:NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...

journal_title：International journal of oncology

authors： Maruyama K,Tsukada T,Ohkura N,Bandoh S,Hosono T,Yamaguchi K

更新日期：1998-06-01 00:00:00

abstract：:The assembly of trans-acting proteins on sequence-specific DNA cis-elements is crucial in the regulation of eukaryotic gene expression. Far upstream element binding proteins (FAB) are proteins that regulate the expression of the c-myc oncogene by binding to the far upstream element of the c-myc gene. The present study...

journal_title：International journal of oncology

authors： Engidawork E,Afjehi-Sadat L,Yang JW,Slavc I,Lubec G

更新日期：2006-09-01 00:00:00

abstract：:A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...

journal_title：International journal of oncology

authors： Tillotson J,Darzynkiewicz Z,Cohen L,Ronai Z

更新日期：1993-07-01 00:00:00

abstract：:A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...

journal_title：International journal of oncology

authors： Ise W,Heuser M,Sanders K,Beck J,Gekeler V

更新日期：1996-05-01 00:00:00

abstract：:Dickkopf-1 (Dkk1), a negative regulator of the Wnt signaling pathway, is implicated in tumorigenesis in several types of cancer. The purpose of this study was to determine the involvement of Dkk1 in oral squamous cell carcinoma (OSCC). We found that Dkk1 is frequently upregulated in OSCC-derived cell lines and primary...

journal_title：International journal of oncology

authors： Ogoshi K,Kasamatsu A,Iyoda M,Sakuma K,Yamatoji M,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K

更新日期：2011-08-01 00:00:00

abstract：:Spindle cell tumors are clinically heterogeneous but morphologically similar neoplasms that can occur anywhere, mostly in adult patients. They are treated primarily with surgery to which is often added adjuvant or neoadjuvant radiation. Sub-classification of spindle cell sarcomas requires integration of histology, cli...

journal_title：International journal of oncology

authors： Panagopoulos I,Bjerkehagen B,Gorunova L,Berner JM,Boye K,Heim S

更新日期：2014-11-01 00:00:00

abstract：:The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...

journal_title：International journal of oncology

authors： Lohmeyer M,Mason S,Gullick W

更新日期：1997-04-01 00:00:00