Characterization of chimeric proteins constructed from human epidermal growth factor (EGF) and the Drosophila EGF-receptor antagonist argos.

abstract：:MicroRNAs can govern up to hundred different mRNAs and are important regulators of gene expression programs in development and disease. We analyzed the expression of microRNA-21, one of the most common oncomirs, in non-small cell lung cancer (NSCLC). Using northern blots the microRNA-21 expression levels of NSCLC-deri...

journal_title：International journal of oncology

authors： Haigl B,Vanas V,Setinek U,Hegedus B,Gsur A,Sutterlüty-Fall H

更新日期：2014-04-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:Cytogenetic abnormalities are the hallmarks of most cancers and cutaneous melanomas are no exception. The purpose of this study was to determine whether nonrandom chromosomal abnormalities are associated with development and spontaneous regression of congenital cutaneous melanoma in Sinclair miniature swine. Careful a...

journal_title：International journal of oncology

authors： Pathak S,Amoss M

更新日期：1997-07-01 00:00:00

abstract：:High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA ...

journal_title：International journal of oncology

authors： Schwarm FP,Uhle F,Schänzer A,Acker T,Stein M,Reinges MH,Weischer C,Weigand MA,Uhl E,Kolodziej MA

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (IAPs), their inhibitor, Smac, and the focal adhesion kinase (FAK) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, NCCIT. We demonstrated that specifically in laminin-adheren...

journal_title：International journal of oncology

authors： Andjilani M,Droz JP,Benahmed M,Tabone E

更新日期：2006-02-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Retinoids, which include vitamin A (retinol) and its derivatives, have previously been investigated as potential chemopreventive and chemotherapeutic agents in bladder cancer. We examined mRNA expression of the retinoid receptors RARalpha, RARbeta2, RARgamma and RXRalpha, as well as two putative RARbeta2 target genes,...

journal_title：International journal of oncology

authors： Boorjian S,Scherr DS,Mongan NP,Zhuang Y,Nanus DM,Gudas LJ

更新日期：2005-04-01 00:00:00

abstract：:Approval of the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab by the FDA in 2004 reflected the success of this vascular targeting strategy in extending survival in patients with advanced cancers. However, consistent with previous reports that experimental tumors can grow or recur during VEGF bloc...

journal_title：International journal of oncology

authors： Huang J,Bae JO,Tsai JP,Kadenhe-Chiweshe A,Papa J,Lee A,Zeng S,Kornfeld ZN,Ullner P,Zaghloul N,Ioffe E,Nandor S,Burova E,Holash J,Thurston G,Rudge J,Yancopoulos GD,Yamashiro DJ,Kandel JJ

更新日期：2009-01-01 00:00:00

abstract：:One hundred five patients with clinical stage T2-T4 transitional cell bladder carcinoma who completed either low-dose (20-26 Gy) or high dose (40-50 Gy) preoperative radiotherapy (RT) followed by cystectomy were reviewed. Five-year actuarial survival was 42%, 52%, and 17% for stages T2, T3, and T4, respectively. Five-...

journal_title：International journal of oncology

authors： Cox J,Greven K,Anscher M,Morgan T

更新日期：1992-10-01 00:00:00

abstract：:Mesothelioma is an aggressive tumor which is mainly derived from the pleura of lung. In the present study, we evaluated the anticancer effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor on human mesothelioma cells in relation to the levels of HDAC1, reactive oxygen species (ROS) a...

journal_title：International journal of oncology

authors： You BR,Park WH

更新日期：2016-05-01 00:00:00

abstract：:Bone is a common site of osteolytic and richly vascularized metastases of renal cell carcinoma (RCC) and Interferon (IFN)-alpha based therapies have been considered for the treatment of patients affected by this disease. The effects of IFN-alpha on metastatic RCC patients have been related to its immunomodulatory, and...

journal_title：International journal of oncology

authors： Avnet S,Cenni E,Perut F,Granchi D,Brandi ML,Giunti A,Baldini N

更新日期：2007-02-01 00:00:00

abstract：:Autologous bone marrow transplantation (ABMT) often produces durable remission in patients with intermediate-high grade non-Hodgkin's lymphoma (NHL). We present a retrospective review of 32 eligible newly diagnosed patients with NHL treated with conventional induction chemotherapy followed by ABMT consolidation therap...

journal_title：International journal of oncology

authors： Montuoro A,Lalle M,Ingletto D

更新日期：2000-10-01 00:00:00

abstract：:Gene amplification is a frequent event in lung cancer, specifically in squamous cell lung carcinoma. Recently, we reported amplifications on chromosomal bands 3q26.1-q26.3 with the genes BCHE and SLC2A2 amplified in 40% of squamous cell lung carcinomas. Here, we identified an amplified domain within chromosomal bands ...

journal_title：International journal of oncology

authors： Rácz A,Brass N,Höfer M,Sybrecht GW,Remberger K,Meese EU

更新日期：2000-07-01 00:00:00

abstract：:Activation of the Wingless (Wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. Depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the s...

journal_title：International journal of oncology

authors： Teiten MH,Gaascht F,Cronauer M,Henry E,Dicato M,Diederich M

更新日期：2011-03-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that transmits signals through G-protein-coupled receptors to control cellular differentiation, survival, and several functions of immune cells. S1P is a chemoattractant for NK cells, which are critical members of the immunological tumor surveillance machinery....

journal_title：International journal of oncology

authors： Lagadari M,Lehmann K,Ziemer M,Truta-Feles K,Berod L,Idzko M,Barz D,Kamradt T,Maghazachi AA,Norgauer J

更新日期：2009-01-01 00:00:00

abstract：:Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. ...

journal_title：International journal of oncology

authors： Kubo T,Sugita T,Shimose S,Nitta Y,Ikuta Y,Murakami T

更新日期：2000-08-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...

journal_title：International journal of oncology

authors： Rello-Varona S,Stockert JC,Cañete M,Acedo P,Villanueva A

更新日期：2008-06-01 00:00:00

abstract：:Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this gene in a large series of primary tumors located outside the gastrointestinal tract which have been associated with loss ...

journal_title：International journal of oncology

authors： Verbeek W,Spirin K,Hatta Y,Miller C,Kawamata N,Takeuchi S,Koike M,Asou H,Simpson J,Koeffler H

更新日期：1997-02-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...

journal_title：International journal of oncology

authors： Liu ZY,Qiu HO,Yuan XJ,Ni YY,Sun JJ,Jing W,Fan YZ

更新日期：2012-11-01 00:00:00

abstract：:Extracellular matrix breakdown as well as increased expression in cancer cells and tumor microvascular endothelial cells make matrix metalloproteinase 2 (MMP2) an attractive target for cancer treatment. By taking advantage of MMP2's properties, an MMP2 cleavable melittin/avidin conjugate was designed. Melittin alone i...

journal_title：International journal of oncology

authors： Holle L,Song W,Holle E,Wei Y,Wagner T,Yu X

更新日期：2003-01-01 00:00:00

abstract：:Conventional cancer treatments are not adequate for the majority of most patients stricken with squamous cell carcinomas of the head and neck (SCCHN). Conditionally replicating adenoviruses (CRAds) represent a promising new modality for treating of neoplastic diseases, including SCCHN. Specifically, CRAd agents infect...

journal_title：International journal of oncology

authors： Zhu ZB,Mathis JM,Makhija SK,Lu B,Wang M,Ji S,Rivera AA,Rosenthal EL,Siegal GP,Curiel DT

更新日期：2007-11-01 00:00:00

abstract：:Metastatic disease commonly occurs in the spine and incidence is likely to increase secondary to improved survival rates in many cancer patients. Despite published research on instability in patients with metastatic disease of the thoracolumbar spine, controversy exists regarding risk factors for instability and indic...

journal_title：International journal of oncology

authors： Weber MH,Burch S,Buckley J,Schmidt MH,Fehlings MG,Vrionis FD,Fisher CG

更新日期：2011-01-01 00:00:00

abstract：:In the present study, the cc‑006cpm8 novel colon cell line was established from a sample of right colorectal adenocarcinoma obtained from a woman with liver metastasis. It was possible to culture this cell line for ≥100 passages in vitro with vigorous growth. Morphologically, the cells grew as several layers with tigh...

journal_title：International journal of oncology

authors： Chu X,Xue Y,Huo X,Wei J,Chen Y,Han R,Chen H,Su X,Zhang H,Gong Y,Chen J

更新日期：2019-07-01 00:00:00

abstract：:Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2021-01-11 00:00:00

abstract：:MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...

journal_title：International journal of oncology

authors： Kim EA,Kim TG,Sung EG,Song IH,Kim JY,Doh KO,Lee TJ

更新日期：2017-03-01 00:00:00

abstract：:Curcumin shows growth-inhibition against tumor cells through multi-target mechanisms. Nevertheless, the poor stability and pharmacokinetics considerably limit its clinical functions. Increased effort has been put into the chemical alteration of curcumin to find potential analogues with improved bioavailability and ant...

journal_title：International journal of oncology

authors： Pan Y,Liu G,Xiao J,Su B,Zhou F,Wei Y

更新日期：2016-05-01 00:00:00

abstract：:The suppressors of cytokine signaling (SOCS) family inhibits not only Janus kinase (JAK)/signal transducers and activators of transcription (STAT) but also focal adhesion kinase (FAK) signaling pathways, and has tumor suppressor activity. Aberrant methylation in the promoter region of the SOCS3 gene frequently occurs ...

journal_title：International journal of oncology

authors： Tokita T,Maesawa C,Kimura T,Kotani K,Takahashi K,Akasaka T,Masuda T

更新日期：2007-03-01 00:00:00

abstract：:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotensio...

journal_title：International journal of oncology

authors： Cheung NK,Kushner BH,Yeh SD,Larson SM

更新日期：1998-06-01 00:00:00

abstract：:Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...

journal_title：International journal of oncology

authors： Tsai SY,Hsieh TC,Ardelt B,Darzynkiewicz Z,Wu JM

更新日期：2002-05-01 00:00:00