Abstract:
:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three forms of cytochrome P450 (CYP1A1, CYP1A2 and CYP2E1) were detected in the colon cell line and all of them were induced following chemical treatments. Altered expression of c-fos, c-myc, c-jun, was observed following the treatments. c-src, K-ras and p53 were not significantly affected by any of the treatments at the time-point selected. Interestingly, c-fos expression was the most dramatically altered by different treatments, showing repression with all of the treatments. These data show that some oncogenes are responsive to inducers of cytochrome P450, the enzyme system by which many carcinogens are activated.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Vasquez H,Strobel Hdoi
10.3892/ijo.9.3.427subject
Has Abstractpub_date
1996-09-01 00:00:00pages
427-31issue
3eissn
1019-6439issn
1791-2423journal_volume
9pub_type
杂志文章abstract::The molecular mechanism playing a role in the development of benign prostate hypertrophy (BPH) and prostate cancer (PC) is not well defined. We performed microarray analysis to assess the gene expression change in BPH and PC, and performed network analysis. Normal prostate, BPH and PC tissues were obtained from patien...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000361
更新日期:2009-09-01 00:00:00
abstract::The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.4.785
更新日期:1999-04-01 00:00:00
abstract::In the present study, the precise mechanism of the enhancing action of histone deacetylase (HDAC) inhibitors on cisplatin (CDDP)-induced apoptosis was investigated using suberoylanilide hydroxamic acid (SAHA) in human oral squamous cell carcinoma cells (HSC-3). HDAC inhibitors are promising novel compounds for the tre...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::This retrospective study looks at the differences between adolescents (15-19 years) and young adults (20-25 years), diagnosed with Hodgkin lymphoma and treated at the same adult institution. Outcome according to risk category was evaluated, and although there were no significant differences in the whole cohort, or low...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.33.1.145
更新日期:2008-07-01 00:00:00
abstract::Resistance to radiotherapy and chemotherapy currently represents one of the major reasons for therapeutic failure in nasopharyngeal carcinoma (NPC). However, the mechanisms underlying resistance to chemotherapy in NPC remain unclear. In this study, cell counting assay, cell cycle assay and senescence associated β-gala...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4462
更新日期:2018-09-01 00:00:00
abstract::Telomerase activity and its subunits (hTERC, hTERT mRNA) were evaluated in ovarian tumours in relation to the expression of p53, c-Myc and estrogen receptor (ER). Furthermore, relations between telomerase activity, hTERC and hTERT with known clinicopathologic prognostic factors and survival in patients with malignant ...
journal_title:International journal of oncology
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doi:10.3892/ijo.23.5.1451
更新日期:2003-11-01 00:00:00
abstract::Neuroblastoma, originated from neural crest cells, is the most common extracranial solid tumor in childhood. In the present study, we evaluated in vitro the oncolytic effect of live-attenuated poliovirus on human neuroblastoma cell lines, and in vivo its therapeutic efficacy in human neuroblastoma-bearing athymic mice...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Antisense oligonucleotides have been investigated as anticancer agents administered alone or in combination with conventional chemotherapeutics. In the present study, we demonstrated synergistic effects between anti-MDM2 antisense oligonucleotides and the clinically used anticancer agent irinotecan, using nude mouse m...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract::The prognostic significance of 20 putative markers has been assessed in a consecutive series of 1,198 patients with malignant lymphoma seen by the Sheffield Lymphoma Group over three decades. Univariate analysis disclosed that ten factors for both Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) Grade I, and tw...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.6.1203
更新日期:2001-12-01 00:00:00
abstract::The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signal...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2011.1312
更新日期:2012-03-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4021
更新日期:2017-07-01 00:00:00
abstract::Tumor metastases are the ultimate target in cancer therapy. In epithelial malignancies, the expression of high-mobility-group A2 (HMGA2) is associated with disease progression and the epithelial-mesenchymal transition (EMT), which is involved in the metastatic process. The present study assessed the clinical and molec...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2947
更新日期:2015-01-01 00:00:00
abstract::We examined the clinical significance of E-cadherin and vimentin expression in 83 patients with breast dancer. E-cadherin expression was correlated with axillary metastases, histologic grade, recurrence and disease-free survival, but not with overall survival. On the other hand, vimentin expression was correlated with...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.9.4.755
更新日期:1996-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.4.791
更新日期:1998-10-01 00:00:00
abstract::The proper structure of the extracellular matrix, in particular of the basement membrane and the adjacent interstitial matrix, are essential prerequisites for a proper function of tissues. Invasive growth in malignant tumors is associated with a destruction of various matrix structures. Due to extensive recent analyse...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.18.4.669
更新日期:2001-04-01 00:00:00
abstract::Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1131
更新日期:2011-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an ou...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.6.1283
更新日期:1994-06-01 00:00:00
abstract::Gene amplification is an important phenomenon in the pathogenetics of malignancy. A method is defined which allows the determination of gene amplification from any sample from which RNA can be obtained, and requires no a priori knowledge of the cytogenetic or genomic state of the tumor. This method allows the determin...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::Retinoids, which include vitamin A (retinol) and its derivatives, have previously been investigated as potential chemopreventive and chemotherapeutic agents in bladder cancer. We examined mRNA expression of the retinoid receptors RARalpha, RARbeta2, RARgamma and RXRalpha, as well as two putative RARbeta2 target genes,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract::Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000431
更新日期:2009-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::The presence of cancer stem cells in both solid and hematopoietic malignancies, has been recently linked to their pathogenesis. Sarcomas are rare, and diversely characterized by degrees of mesenchymal differentiation. The aim of the current study was to demonstrate whether the human sarcoma cell lines, osteosarcoma MG...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract::Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.3.439
更新日期:1996-03-01 00:00:00
abstract::Genetically engineered stem cells (GESTECs) producing suicide enzymes and immunotherapeutic cytokines have therapeutic effects on tumors, and may possibly reduce the side effects of toxic drugs used for treatments. Suicide enzymes can convert non-toxic pro-drugs to toxic metabolites that can reduce tumor growth. Cytos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1288
更新日期:2012-04-01 00:00:00
abstract::Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorub...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.1.6.687
更新日期:1992-11-01 00:00:00
abstract::Recent studies have demonstrated that natural antisense transcripts, which are complementary sequences to messenger RNA, have important cellular functions such as the stabilization and silencing of mRNA. However, the possible contribution of antisense transcripts in hepatocellular c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1382
更新日期:2012-06-01 00:00:00
abstract::We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.5.753
更新日期:1993-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.6.1279
更新日期:2001-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1804
更新日期:2013-04-01 00:00:00